Hepatic elemental contents and antioxidant enzyme activities in Algerian mice (Mus spretus) inhabiting a mine area in central Portugal

Viegas-Crespo, Ana Maria; Lopes, Paula A.; Pinheiro, Teresa; Santos, Maria Cristina; Rodrigues, Patrícia; Nunes, Ana Cláudia; Marques, Claúdia R.; Mathias, Maria da Luz

doi:10.1016/s0048-9697(03)00136-0

Cited by 31 publications

(10 citation statements)

References 26 publications

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“…In rodents (Fouché court and Riviè re, 1995;Li et al, 2006) and insectivores (Hamers et al, 2006) sex-dependent variation has been previously reported in enzymes from detoxification systems. Nonetheless, no differences were found in C. russula in the present study, in agreement with other surveys using wild populations of small mammals (Lopes et al, 2002;Viegas-Crespo et al, 2003). These divergent results may be indicative of inter-species and/or inter-populations differences.…”

Section: Enzymatic Parameterssupporting

confidence: 87%

“…It is well documented that heavy metal exposure alters the normal activity of antioxidant enzymes, as reported in laboratory and wild mammals (e.g. Li et al, 2006;Lopes et al, 2002;Pinheiro et al, 2001;Reynolds et al, 2006;Viegas-Crespo et al, 2003). However, data with measurements on these parameters are quite scarce for shrews (Hamers et al, 2006;Marques et al, 2007).…”

Section: Enzymatic Parametersmentioning

confidence: 99%

“…In fact, several studies have showed that metal exposure can cause alterations of GPx, GST, and GR activities, preventing some adverse effects of oxidative stress induced by the production of ROS species (e.g. Cnubben et al, 2001;Jadhav et al, 2007;Li et al, 2006;Viegas-Crespo et al, 2003).…”

Section: Enzymatic Parametersmentioning

confidence: 99%

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Haematology, genotoxicity, enzymatic activity and histopathology as biomarkers of metal pollution in the shrew Crocidura russula

Sánchez-Chardi

Marques

Gabriel

et al. 2008

Environmental Pollution

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Haematological (WBC, RBC, Hgb and Hct) and genotoxicity (MNT) parameters, hepatic enzymatic activities (GST, GPx and GR), and a histopathological evaluation of liver, kidneys and gonads were assessed as general biomarkers of metal pollution in the shrew Crocidura russula inhabiting a pyrite mining area. Specimens exposed to metals presented a few significant alterations when compared with reference animals: GST activity decreased; micronuclei increased; and evident liver alterations related to metal exposure were observed. On the basis of all the parameters studied, age was an important factor that partly explained the observed variation, whereas sex was the least important factor. Significant correlations were also found between heavy metal concentrations and biomarkers evaluated, demonstrating the great influence of these metals in the metabolic alterations. To the best of our knowledge, these data constitute the first measurements of a battery of biomarkers in shrews from a mine site and are among the few available for insectivorous mammals.

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Section: Enzymatic Parameterssupporting

confidence: 87%

Section: Enzymatic Parametersmentioning

confidence: 99%

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Haematology, genotoxicity, enzymatic activity and histopathology as biomarkers of metal pollution in the shrew Crocidura russula

Sánchez-Chardi

Marques

Gabriel

et al. 2008

Environmental Pollution

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“…ROS, such as superoxide (O2-), hydroxyl (OH -), and hydrogen peroxide (H2O2), are continuously produced at low levels during normal oxidative metabolism in biological systems. However, increased ROS formation due to exposure to chemical substances such as heavy metals generates oxidative stress, promoting harmful effects on DNA, lipids, and proteins and as a result, the functional impairments of enzymes and other important macromolecules happen [29].…”

Section: Heavy Metal Concentrations Of the Samplesmentioning

confidence: 99%

Heavy Metal-Associated Chromosomal Aberrations in Subterranean Mammals (Rodentia: Spalacidae) From Polluted Soils

Yağcı

Gurbanov

2020

Eskişehir Teknik Üniversitesi Bilim Ve Teknoloji Dergisi - C Yaşam Bilimleri Ve Biyoteknoloji

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In this preliminary study, the chromosomal aberrations were investigated for the first time in the subterranean Nannospalax xanthodon species. The locations in Bilecik province where the samples were collected were divided into the polluted and nonpolluted area. The concentrations of cadmium, copper, nickel, lead, and zinc were measured on the Atomic Absorption Spectrometer in the soil samples and liver tissues of the animals. The metal levels detected in liver tissues were found to be higher than the metal levels of soil samples. Therefore, Nannospalax species were considered as appropriate bioindicators for the determination of terrestrial pollution. The examination of chromosomes revealed intense deletions and fragmentations in the chromosome plates of samples from the polluted area. It was concluded that these chromosome aberrations can be associated with metal pollution.

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“…M. spretus is a non-protected rodent that attains high population densities, typically inhabits marshlands, and feeds on plants, seeds, and insects around its burrow. M. spretus has proven to be a useful sentinel species in monitoring programs through the use of different biometric, cytogenetic, and biochemical biomarkers (Bonilla-Valverde et al 2004;Marques et al 2006;Mateos et al 2008;Ruiz-Laguna et al 2006;RuizLaguna et al 2001;Viegas-Crespo et al 2003) and the use of global proteomic (Montes-Nieto et al 2007) and transcriptomic (Abril et al 2014;Abril et al 2011;RuizLaguna et al 2006) analyses. M. spretus diverged from the model mice M. musculus approximately 1.5 million years ago, but both species conserve a remarkable nucleotide sequence similarity (Abril et al 2014;Abril et al 2012;Mahler et al 2008;Ruiz-Laguna et al 2006).…”

Section: Introductionmentioning

confidence: 99%

Global gene expression profiling using heterologous DNA microarrays to analyze alterations in the transcriptome of Mus spretus mice living in a heavily polluted environment

Ruiz-Laguna

Vélez

Pueyo

et al. 2015

Environ Sci Pollut Res

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Microarray platforms are a good approach for assessing biological responses to pollution as they enable the simultaneous analyses of changes in the expression of thousands of genes. As an omic and non-targeted methodology, this technique is open to unforeseen responses under particular environmental conditions. In this study, we successfully apply a commercial oligonucleotide microarray containing Mus musculus whole-genome probes to compare and assess the biological effects of living in a heavily polluted settlement, the Domingo Rubio stream (DRS), at the Huelva Estuary (SW Spain), on inhabitant free-living Mus spretus mice. Our microarray results show that mice living in DRS suffer dramatic changes in gene and protein expression compared with reference specimens. DRS mice showed alteration in the oxidative status of hepatocytes, with activation of both the innate and the acquired immune responses and the induction of chronic inflammation, accompanied by metabolic alterations that imply the accumulation of lipids in the liver (hepatic steatosis). The identified deregulated genes may be useful as biomarkers of environmental pollution.

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Hepatic elemental contents and antioxidant enzyme activities in Algerian mice (Mus spretus) inhabiting a mine area in central Portugal

Cited by 31 publications

References 26 publications

Haematology, genotoxicity, enzymatic activity and histopathology as biomarkers of metal pollution in the shrew Crocidura russula

Haematology, genotoxicity, enzymatic activity and histopathology as biomarkers of metal pollution in the shrew Crocidura russula

Heavy Metal-Associated Chromosomal Aberrations in Subterranean Mammals (Rodentia: Spalacidae) From Polluted Soils

Global gene expression profiling using heterologous DNA microarrays to analyze alterations in the transcriptome of Mus spretus mice living in a heavily polluted environment

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