Hepatic epithelioid hemangioendothelioma: A great mimicker

Llueca, Antoni; Piquer, Dolors; Maazouzi, Yasmine; Medina, Carmen; Delgado, Katty; Serra, Anna; Escrig-Sos, Javier

doi:10.1016/j.ijscr.2018.10.013

Cited by 11 publications

(15 citation statements)

References 10 publications

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“…Compared with other malignant liver tumors, HEHE has a good prognosis. One study reported that 50% of the patients survived more than 5 years without any treatment, and the presence of metastasis did not prolong or shorten the survival rate[ 68 ]. Still, in other studies, successful hepatectomy or LT was shown to promote long-term survival[ 3 , 69 ], with 1- and 3-year disease-free survival rates of 83.3% and 44.4% after hepatectomy, respectively, as well as 1- and 5-year survival rates of 100% and 75%, respectively.…”

Section: Prognosismentioning

confidence: 99%

Hepatic epithelioid hemangioendothelioma: Update on diagnosis and therapy

Kou

Chen

Zhou

et al. 2020

WJCC

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With an estimated incidence of only 1-2 cases in every 1 million people, hepatic epithelioid hemangioendothelioma (HEHE) is a rare vascular endothelial cell tumor occurring in the liver and consisting of epithelioid and histiocyte-like vascular endothelial cells in mucus or a fibrotic matrix. HEHE is characterized as a low-to-moderate grade malignant tumor and is classified into three types: solitary, multiple, and diffuse. Both the etiology and characteristic clinical manifestations of HEHE are unclear. However, HEHE has a characteristic appearance on imaging including ultrasound, magnetic resonance imaging, and positron emission tomography/computerized tomography. Still, its diagnosis depends mainly on pathological findings, with immunohistochemical detection of endothelial markers cluster of differentiation 31 (CD31), CD34, CD10, vimentin, and factor VIII antigen as the basis of diagnosis. Hepatectomy and/or liver transplantation are the first choice for treatment, but various chemotherapeutic drugs are reportedly effective, providing a promising treatment option. In this review, we summarize the literature related to the diagnosis and treatment of HEHE, which provides future perspectives for the clinical management of HEHE.

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Section: Prognosismentioning

confidence: 99%

Hepatic epithelioid hemangioendothelioma: Update on diagnosis and therapy

Kou

Chen

Zhou

et al. 2020

WJCC

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“…Lesions appear hypoechoic on ultrasound. 3 Non-contrast CT shows nodules with a hypodense appearance, while CT with contrast shows small lesions (< 2 cm) with homogenous enhancement and large lesions with peripheral or heterogenous enhancement. 2 Lesions appear hypointense on T1 weighted MRI and hyperintense on T2 weighted MRI.…”

Section: Discussionmentioning

confidence: 99%

Hepatic Epithelioid Hemangioendothelioma Discovered Incidentally on Computerized Tomography

Johnson

Ford

Johnson

2021

kjm

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“…At present, EHE is usually said to be lethal in 50% of cases 5 ; however, the clinical course is quite variable as reported 1,3 . A Japanese study on EHE by Shiba et al.…”

Section: Figurementioning

confidence: 98%