Hepatic Epithelioid Hemangioendothelioma: A Rare Disease With Favorable Outcomes After Liver Transplantation

Krasnodębski, Maciej; Grąt, Michał; Morawski, Marcin; Wierzchowski, Michał; Jastrzębski, Maciej; Remiszewski, Piotr; Zając, Krzysztof; Patkowski, Waldemar; Zieniewicz, Krzysztof

doi:10.1016/j.transproceed.2020.02.101

Cited by 9 publications

(7 citation statements)

References 11 publications

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“…Less commonly, the fusion found is YAP1-TFE3, detected by TFE3 immunoreactivity (4). While HEHE has been known as a slow-growing tumor of indolent nature (5)(6)(7), this is the first case report in which the tumor growth was measured, showing nodules that enlarged and spread to other organs in a given time span.…”

Section: Introductionmentioning

confidence: 81%

“…Less commonly, the fusion found is YAP1-TFE3, detected by TFE3 immunoreactivity ( 4 ). While HEHE has been known as a slow-growing tumor of indolent nature ( 5 - 7 ), this is the first case report in which the tumor growth was measured, showing nodules that enlarged and spread to other organs in a given time span. We present the following case in accordance with the CARE reporting checklist (available at https://tgh.amegroups.com/article/view/10.21037/tgh-22-48/rc ).…”

Section: Introductionmentioning

confidence: 83%

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Hepatic epithelioid hemangioendothelioma: how fast does it grow and which findings could have prevented diagnostic delay?—a case report

Ribeiro¹,

Lemos²,

Moraes³

et al. 2023

Transl Gastroenterol Hepatol

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Background: Hepatic epithelioid hemangioendothelioma (HEHE) is a rare neoplastic disease of varied presentation and unspecific radiological signs in the early stages. The diagnostic delay can lead to metastatic disease, thus increasing the tumor burden and reducing the treatment options. HEHE is usually deemed a slow-growing tumor, but its speed of growth is poorly reported and still unknown.Case Description: In this case report, we documented a HEHE diagnosed in a young woman who had complaints of abdominal pain, weight loss and bloating for a long time. The typical findings observed in histological studies were not promptly recognized in the histological analyzes, even after two laparoscopicguided liver biopsies, delaying the diagnosis until extrahepatic tumor spreading. Findings observed in computed tomography, magnetic resonance imaging and histological studies are presented. The coalescence of nodules and the rising of giant masses, occupying large parts of the liver in a specific time span, were registered and quantified. As opposed to prior reports, the results show that hepatic HEHE can grow rapidly, reinforcing the need of early diagnosis, thus avoiding the complications presented herein. Conclusions:The findings observed via radiological and histological imaging that could have avoided the diagnosis delay are depicted and discussed, showing that HEHE can rise faster than previously documented.

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Section: Introductionmentioning

confidence: 81%

Section: Introductionmentioning

confidence: 83%

Hepatic epithelioid hemangioendothelioma: how fast does it grow and which findings could have prevented diagnostic delay?—a case report

Ribeiro¹,

Lemos²,

Moraes³

et al. 2023

Transl Gastroenterol Hepatol

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“…Several surgical approaches, like hepatic artery ligation, hepatic resection, or LT, have been utilized to cure HEHE (Table 2) (14)(15)(16)(17)(18)(19)(20)(21)(22)(23)(24)(25)(26)(27)(28)30,32,33,50,63). Hepatectomy is adopted to cure localized single lesions, whilst LT represents the treatment of choice to treat multifocal diseases (51).…”

Section: Discussionmentioning

confidence: 99%

The challenging surgical management of hepatic epithelioid hemangioendothelioma: a narrative review

Giovanardi¹,

Laureiro²,

Meo³

et al. 2022

Chin Clin Oncol

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Background and Objective: Hepatic epithelioid hemangioendothelioma (HEHE) is an uncommon vascular endothelial cell cancer involving the hepatic tissue with full malignant potential. HEHE diagnosis is challenging because blood tests and radiological findings are often non-pathognomonic. Therapeutic possibilities are manifold, ranging from a simple "wait and see" to surgical approaches, up to systemic therapies with vascular endothelial growth factor (VEGF) and mechanistic target of rapamycin (mTOR) inhibitors. The standardized adoption of the surgical approaches, namely resection or transplantation, still remains unclear.Aim of this review is to clarify the role of the surgical strategies for the management of HEHE.Methods: A review of the literature was done with the intent to focus on the relevant studies exploring the role of the different surgical therapies. A search of these studies was done using the electronic database MEDLINE-PubMed.

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“…As a low-grade neoplasm, prognosis of HEH is better than that of benign liver hemangioma but worse than the prognosis of malignant liver hemangiosarcoma [20,21]. Table 7 summarizes survival outcomes based on the interventions performed in different reports [8,[13][14][15][21][22][23][24][25][26][27][28].…”

Section: Discussionmentioning

confidence: 99%

Treatment and Prognosis of Hepatic Epithelioid Hemangioendothelioma: A SEER Database Analysis

et al. 2021

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Background Hepatic epithelioid hemangioendothelioma (HEH) is a rare tumor that can affect multiple organs. Little is known about the pathophysiology, clinical course and management of this disease. The aim of this study is to determine survival rates and elucidate the role of various prognostic factors and therapeutic modalities as compared to surgery on patients with HEH. Methods A retrospective analysis on patients diagnosed with HEH between 2004 and 2016 was performed utilizing the SEER database. Kaplan–Meier curves were constructed to determine overall and cancer‐specific survival, and the log‐rank test was used to compare between groups. To explore prognostic factors and treatment outcomes, univariable and multivariable Cox proportional hazard models were developed. Results A total of 353 patients with HEH (median age: 50.4 years) were identified. The most common surgery performed was liver resection (90.8%). One‐year OS in the surgical group and non‐surgical group was 86.6% and 61.0%, respectively, while 5‐year OS was 75.2% and 37.4%, respectively. On multivariable analysis, surgery emerged as a favorable prognostic factor [HR (95%CI): 0.404 (0.215–0.758) p value = 0.005]. Age > 65 years [HR (95%CI): 2.548 (1.442–4.506) p value = 0.001] and tumor size > 10 cm [HR (95%CI): 2.401 (1.319–4.37) p value = 0.004] were shown to be poor survival prognostic factors. Conclusion HEH is a rare disease that is poorly understood. Surgical intervention is associated with improved survival rates. Multicenter prospective collaborations are needed to improve our limited knowledge about this neoplasm and determine the optimal treatment strategy.

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Hepatic Epithelioid Hemangioendothelioma: A Rare Disease With Favorable Outcomes After Liver Transplantation

Cited by 9 publications

References 11 publications

Hepatic epithelioid hemangioendothelioma: how fast does it grow and which findings could have prevented diagnostic delay?—a case report

Hepatic epithelioid hemangioendothelioma: how fast does it grow and which findings could have prevented diagnostic delay?—a case report

The challenging surgical management of hepatic epithelioid hemangioendothelioma: a narrative review

Treatment and Prognosis of Hepatic Epithelioid Hemangioendothelioma: A SEER Database Analysis

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