Hepatic glucokinase activity and circulating insulin concentrations in two inbred mouse strains

Lavender, F L; James, Patricia; Walker, Deryck G.

doi:10.1007/bf00250898

Cited by 6 publications

(2 citation statements)

References 27 publications

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“…, o significantly by glucagon (Fig. Hormonal and metabolic differences between different strains of animals have been reported previously ( 12,13). The increase 5 The conversion of [ ''C]alanine to glucose was Discussion.…”

Section: Resultssupporting

confidence: 57%

The Relationship between Glucagon Receptors and Metabolic Profile in Two Strains of Rats: Wistar-Furth and Sprague-Dawley

Dunbar

Wider

Dixon

et al. 1987

Experimental Biology and Medicine

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We studied glucagon and insulin binding to isolated hepatocyte receptors in Wistar-Furth (WF) and Sprague-Dawley (SD) rats, using '251-labeled hormones. Hepatocytes from WF rats bound more glucagon than hepatocytes from SD rats. There were no differences in insulin binding. These observations prompted us to investigate other strain differences. Fasting and nonfasting serum glucose, glucagon, insulin, and growth hormone were measured. WF animals had a lower fasting glucose and higher fasting glucagon than SD animals, while SD rats had higher nonfasting insulin levels and a higher hepatic glycogen content. Total hepatic glucose production in response to glucagon ( M ) was greater in WF than in SD rats, while glucagon-stimulated gluconeogenesis from alanine was the same in the two groups of animals. We concluded that the decreased glucagon binding does not play a significant role in the maintenance of serum glucose or in the gluconeogenetic response glucagon, and that neither these responses nor the serum glucagon levels appears to be correlated with the number of glucagon receptors. We conclude further that different animal strains of the same species may differ in their biologic responses. Downloaded from 32-37, 1985. tuitary gland: Effect of age, sex, and hormonal state. Endocrinology (Baltimore) 81: 195-204, 1967. 10. Zahlten RN, Kneer NM, Stratman FW, Lardy HA. The influence of ammonium and calcium ions on

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Section: Resultssupporting

confidence: 57%

The Relationship between Glucagon Receptors and Metabolic Profile in Two Strains of Rats: Wistar-Furth and Sprague-Dawley

Dunbar

Wider

Dixon

et al. 1987

Experimental Biology and Medicine

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“…Given this background of complexity for human diabetes, investigators have used inbred mouse strains for genetic analysis (18)(19)(20)(21)(22)(23)(24)(25)(26). An inbred mouse strain represents an almost limitless resource of genetically identical individuals that are predominantly homozygous at every locus (27).…”

mentioning

confidence: 99%

Genetic Analysis of Glucose Tolerance in Inbred Mouse Strains: Evidence for Polygenic Control

Kaku

Fiedorek²,

Province³

et al. 1988

Diabetes

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To determine genetic factors involved in diabetes susceptibility in inbred strains of mice, we initially evaluated differences in fed plasma glucose and insulin concentrations among six strains (AKR/J, C3H/HeJ, C57BL/6J, C57L/J, DBA/2J, and SWR/J). There was considerable variation in fed plasma glucose concentration, with C3H/HeJ mice the most glucose tolerant (174 +/- 7 mg/dl) and C57BL/6J mice the least glucose tolerant (252 +/- 7 mg/dl, P less than .0001 vs. C3H/HeJ mice). Glycosylated hemoglobin of C57BL/6J mice (4.0 +/- 0.06%) was also higher than that of C3H/HeJ mice (3.52 +/- 0.06%, P less than .0001). The fed plasma insulin concentration did not differ between these two strains. Glucose tolerance was further evaluated in overnight-fasted C3H/HeJ and C57BL/6J mice by an intraperitoneal glucose tolerance test (IPGTT). Although fasting plasma glucose did not differ, the most remarkable difference in plasma glucose during IPGTT between C57BL/6J and C3H/HeJ mice was noted at 30 min (489 +/- 29 vs. 227 +/- 20 mg/dl, P less than .001). To determine the number of genes involved in the phenotypic difference in glucose tolerance, C57BL/6J males were crossed with C3H/HeJ females (F1, C3H/HeJ X C57BL/6J), and the F1 hybrid females were backcrossed with C57BL/6J males (backcrossed, F1 X C57BL/6J). Plasma glucose after 30 min on IPGTT was 219 +/- 8 (n = 21), 456 +/- 18 (n = 23), and 292 +/- 13 (n = 23) mg/dl for C3H/HeJ, C57BL/6J, and F1 mice, respectively (P less than .001 for all comparisons).(ABSTRACT TRUNCATED AT 250 WORDS)

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Variable Expression of Hepatic Glucokinase in Mice Is Due to a Regulational Locus That Cosegregates with the Glucokinase Gene

Moates¹,

Postic²,

Decaux³

et al. 1997

Genomics

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Hepatic glucokinase activity and circulating insulin concentrations in two inbred mouse strains

Cited by 6 publications

References 27 publications

The Relationship between Glucagon Receptors and Metabolic Profile in Two Strains of Rats: Wistar-Furth and Sprague-Dawley

The Relationship between Glucagon Receptors and Metabolic Profile in Two Strains of Rats: Wistar-Furth and Sprague-Dawley

Genetic Analysis of Glucose Tolerance in Inbred Mouse Strains: Evidence for Polygenic Control

Variable Expression of Hepatic Glucokinase in Mice Is Due to a Regulational Locus That Cosegregates with the Glucokinase Gene

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