Hepatic granulomatosis and sarcoidosis

Israel, Harold L.; Margolis, Mitchell L.; Rose, Lewis J.

doi:10.1007/bf01318522

Cited by 66 publications

(31 citation statements)

References 9 publications

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“…Severe pain in the right upper quadrant can be present even without biliary injury. 12,14,15,23 Diagnosis of hepatic granulomatosis A comprehensive medical history and physical examination should be pursued along with an extensive medication and travel history. A reasonable initial approach is to search first for the most common causes of granulomatous liver disease in a particular population to avoid unnecessary testing.…”

Section: Clinical Presentationmentioning

confidence: 99%

Granulomatous liver diseases: A review

Coash

Forouhar

et al. 2012

Journal of the Formosan Medical Association

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Granulomas that consist of focal accumulations of macrophages are commonly found in the liver due to stimulation of the immune system by a number of agents. Manifestations are variable depending on whether the underlying cause is a systemic disease or a primary hepatic granulomatous reaction. This article describes the common causes, presentation, histopathology, and manifestations of granulomatous diseases as well as various diagnostic and management strategies.

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Section: Clinical Presentationmentioning

confidence: 99%

Granulomatous liver diseases: A review

Coash

Forouhar

et al. 2012

Journal of the Formosan Medical Association

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“…Fox et al 57 reported negative Kveim-Siltzbach responses in 9 tested patients with PBC-associated hepatic granulomas on liver biopsy. This finding would argue against coexistent sarcoidosis 60 however, report that negative Kveim-Siltzbach reactions are also a common occurrence in hepatic sarcoidosis and cannot serve as an indication of its absence. Furthermore, 2 cases with concurrent positive Kveim-Siltzbach reactions and elevated AMA titers suggestive of coexistent sarcoidosis and PBC, respectively, have been noted in the literature and are listed in Table 1.…”

Section: Pbc and Sarcoidosis: Distinct Entities Or "Overlap Syndrome"mentioning

confidence: 59%

Pulmonary Manifestations of Primary Autoimmune Hepatobiliary Disease

Allan¹,

Powers²,

Morris³

2005

Clinical Pulmonary Medicine

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The autoimmune hepatobiliary diseases are associated with a variety of pulmonary manifestations. There is increasing evidence of autoimmune pathophysiology occurring within the hepatopulmonary axis that may lead to clinically evident disease. Primary biliary cirrhosis (PBC) figures prominently among the primary autoimmune hepatobiliary processes with pulmonary involvement. PBC has been associated with subclinical alveolitis, sarcoidosis, bronchiolitis obliterans with organizing pneumonia, and lymphoid interstitial pneumonia, among others. Clinical associations have also been made between primary sclerosing cholangitis (PSC) and sarcoidosis, pulmonary fibrosis, or alveolar hemorrhage. Last, an evaluation of the current diagnostic criteria of autoimmune hepatitis has led to a reconsideration of its association with pulmonary fibrosis. Through a heightened clinical suspicion for these potential relationships, an improvement can be made in our comprehension of these autoimmune hepatobiliary processes and their impact on pulmonary physiology.

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“…There are a few reports of a variety of treatments for liver involvement with sarcoid. These include chloroquine (10), chlorambucil (11), methotrexate (12), and D-penicillamine (5). Drugs used are also based on the similarity at times between sarcoid of the liver and primary biliary cirrhosis (PBC).…”

Section: Discussionmentioning

confidence: 99%