Hepatic Hemangiomas Alter Morphometry and Impair Hemodynamics of the Abdominal Aorta and Primary Branches From Computer Simulations

Yin, Xiaoping; Huang, Xiongjian; Li, Qiao; Li, Li; Niu, Pei; Cao, Minglu; Guo, Fei; Li, Xuechao; Tan, Wenchang; Huo, Yunlong

doi:10.3389/fphys.2018.00334

Cited by 11 publications

(11 citation statements)

References 45 publications

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“…Hepatic cavernous hemangioma is the most common benign tumor of the liver (Yin et al, 2018), with a reported prevalence of 20% in autopsy (Bahirwani and Reddy 2008). This tumor is typically observed in females (female: male ratio = 5:1) at an average age of 50 years (Duxbury and Garden 2010).…”

Section: Discussionmentioning

confidence: 99%

Natural history of hepatic hemangioma: a follow-up analysis of 534 patients

Wang

Deng

Qian

et al. 2019

Frontiers in Life Science

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Background: The effects of gender and age on the growth of hepatic hemangioma remain inconclusive. This study aims to further explore the natural growth of hepatic hemangioma and its influencing factors. Methods: From June 2014 to April 2019, 534 untreated patients who were diagnosed with hepatic hemangioma in our hospital were enrolled. The growth changes of hepatic hemangioma were observed at follow-up by ultrasound. Results: During the median 18 (14,22) (months of follow-up, 215 (40.3%) patients showed an increase in tumor diameter, 217 (40.6%) tumor diameters decreased, and102 (19.1%) tumor diameters did not change. Before the age of 40, the diameter of hemangiomas in each group of men and women increased with age. After 40 years old, those in men continued to grow slowly, while those in women had a relatively downward trend. Therefore, by investigating annual changes in tumor, it was found that the diameter of female tumors showed a significant downward trend after the age of 40, the difference is most pronounced between 50-60 years old (the annual change is −0.39 (−0.87,0.40) cm). Conclusion: In the natural growth process of hepatic hemangioma, male and female patients present different trends, which may be related to sex.

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Section: Discussionmentioning

confidence: 99%

Natural history of hepatic hemangioma: a follow-up analysis of 534 patients

Wang

Deng

Qian

et al. 2019

Frontiers in Life Science

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“…The expression or functionality of TRPV in BMEC forming the BBB was much less studied than in non-cerebral endothelial cells although there is growing evidence that TRP channels may have a critical role at the BBB by modulating Ca 2+ trafficking into BMEC. Dysfunctions of the BBB are increasingly recognized as a cause or a consequence in the pathophysiology of diverse brain pathologies such as stroke, neurodegenerative and psychiatric diseases ( Sweeney et al, 2019 ; Yang et al, 2019 ; Kealy et al, 2020 ; Yu et al, 2020 ). A dysfunctional BBB can thus be targeted with new drug candidates, which would be a promising way for treating brain pathologies.…”

Section: Introductionmentioning

confidence: 99%

Molecular and Functional Study of Transient Receptor Potential Vanilloid 1-4 at the Rat and Human Blood–Brain Barrier Reveals Interspecies Differences

Luo

Saubaméa

Chasseigneaux

et al. 2020

Front. Cell Dev. Biol.

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Transient receptor potential vanilloid 1-4 (TRPV1-4) expression and functionality were investigated in brain microvessel endothelial cells (BMEC) forming the blood–brain barrier (BBB) from rat and human origins. In rat, Trpv1-4 were detected by qRT-PCR in the brain cortex, brain microvessels, and in primary cultures of brain microvessel endothelial cells [rat brain microvessel endothelial cells (rPBMEC)]. A similar Trpv1-4 expression profile in isolated brain microvessels and rPBMEC was found with the following order: Trpv4 > Trpv2 > Trpv3 > Trpv1 . In human, TRPV1-4 were detected in the BBB cell line human cerebral microvessel endothelial cells D3 cells (hCMEC/D3) and in primary cultures of BMEC isolated from human adult and children brain resections [human brain microvascular endothelial cells (hPBMEC)], showing a similar TRPV1-4 expression profile in both hCMEC/D3 cells and hPBMECs as follow: TRPV2 > > TRPV4 > TRPV1 > TRPV3 . Western blotting and immunofluorescence experiments confirmed that TRPV2 and TRPV4 are the most expressed TRPV isoforms in hCMEC/D3 cells with a clear staining at the plasma membrane. A fluorescent dye Fluo-4 AM ester was applied to record intracellular Ca 2+ levels. TRPV4 functional activity was demonstrated in mediating Ca 2+ influx under stimulation with the specific agonist GSK1016790A (ranging from 3 to 1000 nM, EC 50 of 16.2 ± 4.5 nM), which was inhibited by the specific TRPV4 antagonist, RN1734 (30 μM). In contrast, TRPV1 was slightly activated in hCMEC/D3 cells as shown by the weak Ca 2+ influx induced by capsaicin at a high concentration (3 μM), a highly potent and specific TRPV1 agonist. Heat-induced Ca 2+ influx was not altered by co-treatment with a selective potent TRPV1 antagonist capsazepine (20 μM), in agreement with the low expression of TRPV1 as assessed by qRT-PCR. Our present study reveals an interspecies difference between Rat and Human. Functional contributions of TRPV1-4 subtype expression were not identical in rat and human tissues reflective of BBB integrity. TRPV2 was predominant in the human whereas TRPV4 had a larger role in the rat. This interspecies difference from a gene expression point of view should be taken into consideration when modulators of TRPV2 or TRPV4 are investigated in rat models of brain disorders.

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“…Previous studies have revealed that the incidence of HH in the general population is 5-20% [16][17][18] . Statistical analyses of data extracted from the physical examination reports of 670,000 healthy individuals in China revealed that the incidence of HH was approximately 1.5%, and the male to female ratio was approximately 1.3:1.…”

Section: Discussionmentioning

confidence: 99%

Real-world Study of Hepatic Hemangioma at a Single Center --Data from 2008 to 2017

Yang

Liang

et al. 2020

Preprint

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Objective: The objective of the present study was to investigate the clinical and epidemiological characteristics of hepatic hemangioma (HH) and the risk factors for complications associated with HH resection in a single center experience.Materials and methods: Clinical data of 5,266,670 outpatients and 246,419 individuals who were physically examined between 2016 and 2017 were used to evaluate epidemiological profiles of HH. A total of 1,981 patients hospitalized with HH between January 1, 2008 and January 1, 2018 were examined to identify relevant features associated with surgery. Results: The study found that HH was similar in male and female incidence, mostly at the age of 40, and the tumor was usually single and mostly located in the right lobe of the liver. No serious postoperative complications occurred, and the method of HH resection was related to the occurrence of postoperative complications.Conclusion: HH is a common benign disease of the liver. There are certain distribution rules in age, tumor size, and location, and laparoscopic HH resection that can reduce postoperative complications.

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Hepatic Hemangiomas Alter Morphometry and Impair Hemodynamics of the Abdominal Aorta and Primary Branches From Computer Simulations

Cited by 11 publications

References 45 publications

Natural history of hepatic hemangioma: a follow-up analysis of 534 patients

Natural history of hepatic hemangioma: a follow-up analysis of 534 patients

Molecular and Functional Study of Transient Receptor Potential Vanilloid 1-4 at the Rat and Human Blood–Brain Barrier Reveals Interspecies Differences

Real-world Study of Hepatic Hemangioma at a Single Center --Data from 2008 to 2017

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