Hepatic late adverse effects after antineoplastic treatment for childhood cancer

Mulder, Renée L.; Dalen, Elvira C. van; Hof, Malon Van den; Leclercq, Edith; Bresters, Dorine; Koot, Bart; Castellino, Sharon M.; Loke, Yoon K.; Post, Piet N.; Caron, Huib N.; Postma, A.; Kremer, Leontien C. M.

doi:10.1002/14651858.cd008205.pub2

Cited by 26 publications

(7 citation statements)

References 174 publications

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“…In contrast, the median time between stopping the drug to DILI onset in the remaining 29 confirmed DILI cases was 1 day (range 1–42). There were 13 (22.8%) subjects who had a drug latency exceeding 12 months and the suspect agent in these cases included minocycline (6), atomoxetine (2), valproic acid (2), and 1 case each of fluoxetine, mercaptopurine, and methylphenidate DILI. Thirty‐five percent of the children self‐reported a history of drug allergy that includes drug intolerance but none reported a prior episode of DILI.…”

Section: Resultsmentioning

confidence: 99%

Antimicrobials and Antiepileptics Are the Leading Causes of Idiosyncratic Drug‐induced Liver Injury in American Children

DiPaola

Molleston

et al. 2019

J. pediatr. gastroenterol. nutr.

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EGL Genetics specializes in genetic diagnostic testing, with nearly 50 years of clinical experience and board-certified laboratory directors and genetic counselors reporting out cases. EGL Genetics offers a combined 1000 molecular genetics, biochemical genetics, and cytogenetics tests under one roof and custom testing for all medically relevant genes, for domestic and international clients. Equally important to improving patient care through quality genetic testing is the contribution EGL Genetics makes back to the scientific and medical communities. EGL Genetics is one of only a few clinical diagnostic laboratories to openly share data with the NCBI freely available public database ClinVar (>35,000 variants on >1700 genes) and is also the only laboratory with a free online database (EmVClass), featuring a variant classification search and report request interface, which facilitates rapid interactive curation and reporting of variants.

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Section: Resultsmentioning

confidence: 99%

Antimicrobials and Antiepileptics Are the Leading Causes of Idiosyncratic Drug‐induced Liver Injury in American Children

DiPaola

Molleston

et al. 2019

J. pediatr. gastroenterol. nutr.

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“…Cardiac related mortality has been reported to increase ≥10-fold among childhood cancer survivors [18][19][20]. Besides, the risk of late hepatic adverse events have also been stressed [18,21,22]. The iron overloading may contribute to these late morbidities in these patients, in addition to contributing potential endocrinopathies such as hypogonadotropic hypogonadism or hypothyroidism, similar to those reported in patients with ␤ thalassemia major [23,24].…”

Section: Discussionmentioning

confidence: 95%

Number of erythrocyte transfusions is more predictive than serum ferritin in estimation of cardiac iron loading in pediatric patients with acute lymphoblastic leukemia

Ünal¹,

Çetin²,

Hazırolan³

et al. 2014

Leukemia Research

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“…Serum bilirubin, prothrombin time and serum albumin were normal from starting of chemotherapy up to completion. 16 The Cochrane Review database shows liver complications to be common during and soon after treatment for childhood cancer. However, about 8-53% of the childhood cancer survivors developed hepatic late adverse effect after treatment.…”

Section: Introductionmentioning

confidence: 99%

Effect of Chemotherapy on Liver Function During Induction of Remission in Children with Acute Lymphoblastic Leukemia Receiving Standard Protocol

et al. 2021

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Objective: The present study was undertaken to assess liver function (using markers like SGPT, serum bilirubin, prothrombin time, serum albumin) in children suffering from Acute Lymphoblastic Leukemia. Materials & Methods: This study was carried out in the Department of Pediatric Hematology & Oncology, Dhaka Medical College Hospital, Dhaka, over a period 12 months from the day of approval of the protocol. All acute lymphoblastic leukaemia children admitted in Pediatric Hematology & Oncology Department in Dhaka Medical College Hospital and receiving chemotherapy of standard protocol for induction of remission were the study population. A total of outcome variable was hepatotoxicity resulting from chemotherapy given for induction of remission. Result: The mean age of the children was 4.4 years (range 2- 8 years). Males were a bit higher in the series with male to female ratio being 11:9. Liver function tests before therapy revealed that none of the children exhibited raised serum billirubin and only 2(4.5%) children had increased SGPT. However, 50% of the children had raised prothrombin and 43.2% had reduced serum . albumin. Liver function tests after therapy after induction of remission shows that 9(20.5%) children exhibited raised serum billirubin, the proportion of children with raised prothrombin remained almost same as before but the status of serum billirubin improved to some extent. However, proportion of children with raised SGPT was increased to 25%. Comparison of liver function in children after therapy during induction of remission with that before induction did not show any significant difference, except that the serum SGPT was significantly raised during induction of remission (p < 0.001). Conclusion: The study concluded that the current therapy for induction of remission of ALL cases does not produce any toxic effect on liver. Although, enzymes like SGPT take a sharp rise during induction of remission, it is transient and does produce any deleterious effect on liver. J Dhaka Medical College, Vol. 29, No.1, April, 2020, Page 33-37

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Hepatic late adverse effects after antineoplastic treatment for childhood cancer

Abstract: Hepatic late adverse effects after antineoplastic treatment for childhood cancer Mulder, Renee L.; van Dalen, Elvira C.; Van den Hof, Malon; Bresters, Dorine; Koot, Bart G. P.; Castellino, Sharon M.; Loke, Yoon; Leclercq, Edith; Post, Piet N.; Caron, Huib N.

Cited by 26 publications

References 174 publications

Antimicrobials and Antiepileptics Are the Leading Causes of Idiosyncratic Drug‐induced Liver Injury in American Children

Antimicrobials and Antiepileptics Are the Leading Causes of Idiosyncratic Drug‐induced Liver Injury in American Children

Number of erythrocyte transfusions is more predictive than serum ferritin in estimation of cardiac iron loading in pediatric patients with acute lymphoblastic leukemia

Effect of Chemotherapy on Liver Function During Induction of Remission in Children with Acute Lymphoblastic Leukemia Receiving Standard Protocol

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