Hepatic lesions in patients treated with synthetic anabolic steriods.

Sweeney, Eamonn; Evans, D J

doi:10.1136/jcp.29.7.626

Cited by 74 publications

(13 citation statements)

References 18 publications

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“…Liver side effects also include raised serum levels of aspartate and alanine transferase, cholestatic jaundice, and peliosis hepatis. '-3 The association between primary hepatic tumors and androgens was first noted in 1965 by Recant and Lacy and later confirmed by Westaby, but the first case of a hepatoma in an athlete using anabolic steroids was reported by Overly in 1984.6 These drugs also raise the cholesterol while decreasing the high-density lipoproteins and produce salt and water retention and hypertension, [1][2][3][4][5][6][7] BUT, accelerated arteriosclerosis and vascular complications have not been reported. A stimulating effect on the erythropoiesis and polyglobulia have been seen with prolonged use in cancer patients but not demonstrated in athletes.…”

Section: Discussionmentioning

confidence: 97%

“…The carotid angiogram revealed a round 3mm thrombus stuck on the origin of the left internal carotid artery without any wall abnormality (Figs. 2,3). The anterior and posterior parietal branches of the middle cerebral artery were occluded by a small embolus but were revascularized distally by the cortical branches of the anterior cerebral artery.…”

Section: Case Historymentioning

confidence: 98%

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Steroid Anabolic Drugs and Arterial Complications in an Athlete—A Case History

Laroche

1990

Angiology

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Serious side effects and complications have been attributed to anabolic and androgenic steroids when used for medical reasons or when taken in sports in hopes of increasing strength and, hence, performance. The author presents a case of an athlete who experienced two metachronous arterial complications after taking these drugs: a cerebrovascular accident caused by a carotid artery thrombus that partially embolized to the brain and, later, a severe ischemic episode in a lower limb caused by a diffused distal arterial thrombosis. This patient represents the first reported case of vascular events in an otherwise healthy athlete taking androgens to increase his skeletal muscle mass.

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Section: Discussionmentioning

confidence: 97%

Section: Case Historymentioning

confidence: 98%

Steroid Anabolic Drugs and Arterial Complications in an Athlete—A Case History

Laroche

1990

Angiology

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“…Vol. 40 capsulated border with protruding tongues and islands of cells away from the main nodule (Fig. 4).…”

Section: Fig 3 Circumscribed Hepatic Adenoma Has a Large Central Vementioning

confidence: 99%

Multiple hepatic adenomas and a hepatocellular carcinoma in a man on oral methyl testosterone for eleven years

Boyd

Mark

1977

Cancer

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NDROGENIC, ESTROGENIC, AND PROCES-A togenic steroids all exert a metabolic and morphologic effect on the The female and male hormones have different but overlapping effects on the liver. Ingestion of estrogens and progesterones is associated with intrahepatic cholestasis, rise in serum transaminase, increased Bromsulphalein retention, and focal nodular hyperplasia. Ingestion of androgens is associated with cholestasis, peliosis hepatis, and hepatocellular carcinoma. The progesterones and 17-alkylated anabolic steroids affect mainly the smooth endoplasmic reticulum, whereas estrogens affect mainly protein synthesis in rough endoplasmic reticulum. All patients developing jaundice or hepatocellular carcinoma after treatment with anabolic steroids invariably have received compounds containing a methyl or ethyl group at the 17 position, e.g., oxymetholone or methyltestosterone. More From the .James Homer

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“…Such lesions, resulting from abnormal vasculature [20], may be part of the FA phenotype. However, some other cases of NFH after androgen treatment have been reported in non-FA patients [13,21], and this suggests that NFH may be associated with androgens rather than FA.…”

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confidence: 95%

“…In patients with no available donor, androgen treatment may improve blood cell counts [8]. It is now well-established that androgen treatment is a risk factor for liver abnormalities in both FA and non-FA patients [9][10][11][12][13][14]. Some studies have previously reported hepatic tumors in patients with FA [9,15,16], but little is known concerning other abnormalities of the livers of these patients.…”

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confidence: 99%