Hepatic metabolism in ethanol-treated young rats

Abstract

Dams of a Wistar-derived OETI strain were offered a 15% aqueous ethanol solution as drinking-fluid immediately after delivery until weanling. Their offsprings also received the same drinking-fluid from weanling (Group A). Another group of rats received the 15% aqueous ethanol solution only after weanling (Group B). In response to ethanol treatment the retardation of growth was the most marked in Group A, but the growth of rats in Group B was also decreased significantly as compared to that of controls. Hepatic glycogen content was diminished in all of the ethanol-treated groups. Triglyceride content was increased in the livers of female rats in Group A. By comparing earlier results with the present findings the authors point to the importance of strain and sex in experiments when parameters for hepatic metabolism are studied in response to ethanol.

Lipid Profile in Children Born Small for Gestational Age

“…In turn, Antal et al, analysing 14 to 16-year-olds, did not find differences in lipid levels between children with low birth weight and children with normal birth weight. It should be mentioned that the examined children differ according to fetal age, including children born prematurely [24]. Findings similar to ours were presented by Koklu et al in a group of different age (infants with SGA) than our group.…”

“…A positive correlation between elevated levels of total cholesterol, LDL cholesterol and apolipoprotein B in adults born as SGA and a small abdominal circumference observed in the newborn after birth was also revealed [22]. There are relatively few reports referring to research on lipids and/or lipoproteins in the blood serum of SGA children [21,[23][24][25][26][27][28][29]. Although their results vary depending on the studied population, it is worth emphasizing that the assessment of the lipid profile in SGA children is recommended in certain regions [30].…”