Hepatic-Metabolite-Based Intermittent Fasting Enables a Sustained Reduction in Insulin Resistance in Type 2 Diabetes and Metabolic Syndrome

Abstract

Insulin resistance is the hallmark of Type 2 Diabetes and is still an unmet medical need. Insulin resistance lies at the crossroads of non-alcoholic fatty liver disease, obesity, weight loss and exercise resistance, heart disease, stroke, depression, and brain health. Insulin resistance is purely nutrition related, with a typical molecular disease food intake pattern. The insulin resistant state is accessible by TyG as the appropriate surrogate marker, which is found to lead the personalized molecular hepatic nutrition system for highly efficient insulin resistance remission. Treating insulin resistance with a molecular nutrition-centered approach shifts the treatment paradigm of Type 2 Diabetes from management to cure. This allows remission within five months, with a high efficiency rate of 85%. With molecular intermittent fasting a very efficient treatment for prediabetes and metabolic syndrome is possible, improving the non-alcoholic fatty liver disease (NAFL) state and enabling the body to lose weight in a sustainable manner.

The Effect of a Program to Improve Adherence to the Mediterranean Diet on Cardiometabolic Parameters in 7034 Spanish Workers

“…In all of these, a significant reduction was obtained after the diet, finding the highest difference, for both men and women, with the METS-IR. Different previous studies found an improvement in the TyG index with diet [91,92], as shown in our analysis. In a previous cross-sectional study conducted by our research group, we found an association between people following a Mediterranean diet and a lower index of insulin resistance measured with METS-IR [54].…”

Treating Insulin Resistance with Intermittent Personalized Nutrition to Sustain Metabolic Health and Functioning Immune System for Risk Reduction of Viral Diseases Especially COVID-19 and Long-COVID

“…Elevated blood triglycerides accompanied by lower HDL levels represent an insulin-resistant metabolic status and are purely dietrelated. According to Rohner et al (2021), the macromolecular dietary pattern of patients with insulin resistance, prediabetes, or type 2 diabetes shows a similar pathological baseline dietary pattern, independent of BMI. This is characterized by a significant excess intake of saturated fats and glucose and a too low intake of fiber, polyphenols, magnesium, potassium, and vitamin D [Rohner et al 2021].…”

“…Reversal of insulin resistance to a normal response can effectively be achieved through an everyday diet purposed to de-escalate inflammation and rewire the metabolic and signaling landscape by sustained epigenetic remodeling [Rohner et al 2021]. The treatment is a precise personalized molecular nutrition strategy with intermittent fasting enriched with selected nutritional cofactors.…”

Efectos metabólicos del ayuno intermitente en pacientes adultos con síndrome metabólico

“…Existe un notorio descenso de la insulina en la tarde, por lo que las cenas tardías incrementan el riesgo de diabetes y otros componentes del SM (14), se evidenció que la ingesta de alimentos en altas horas de la noche aumentan el riesgo cardiovascular y a su vez esta desregulación del ritmo favorece a la insulinorresistencia, a diferencia de quienes se alimentan solo hasta la mitad del día que revelan un mejor control de lípidos, glucosa e inflamación (7). Por otra parte, la resistencia a la insulina contribuye potencialmente al incremento del Índice de Masa Corporal (IMC) (16). La ultima teoría, hace referencia al estado cetogénico, que al promover a este cambio metabólico intermitente causa el ascenso de las concentraciones de B-hidroxibutirato y el surgimiento de cetonas al cabo de 6 a 8 horas de ayuno.…”

“…Los efectos metabólicos con mayor evidencia científica son cuatro, que incluye pérdida de peso, disminución de las concentraciones séricas de insulinaglucosa, TG, y en algunas ocasiones modificaciones que beneficien la PA (3,7,(16)(17)(18).…”