Hepatic morphologic findings and viral antigens in acute hepatitis B

Houthoff, H. J.; Niermeijer, P; Gips, C. H.; Arends, A; Hofstee, Nikolaas; Guldener, M.

doi:10.1007/bf00439483

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Changing Concepts Of the Evolution Of Chronic1

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1983

1989

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Cited by 13 publications

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“…There is still argument as to whether periportal piecemeal necrosis in acute viral hepatitis indicates transition to chronicity. It was observed at the peck of severity of acute HB and full recovery subsequently took place (20). This group of observers claims that only demonstration of viral antigens in the liver in the acute stage points to possible chronicity.…”

Section: Changing Concepts Of the Evolution Of Chronicmentioning

confidence: 99%

Changing Concepts of the Evolution of Chronic Hepatitis and the Role of Piecemeal Necrosis

Pópper

1983

Hepatology

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Section: Changing Concepts Of the Evolution Of Chronicmentioning

confidence: 99%

Changing Concepts of the Evolution of Chronic Hepatitis and the Role of Piecemeal Necrosis

Pópper

1983

Hepatology

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Ground-glass hepatocytes: A spectrum of inclusions

Gerber

Grases

1986

Hepatology

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A new type of ground‐glass hepatocyte is described. The appearance is due to pale, homogeneous, weakly eosinophilic inclusions filling a portion of or the entire hepatocytic cytoplasm. On haematoxylin and eosin stained sections, these cells closely resemble ground‐glass hepatocytes described in other conditions. However, they are negative on special stains for HBsAg and on PAS staining. Immunohistochemically, they reveal a selective and exclusive positivity for fibrinogen. On electron microscopy, the immunoreactive fibrinogen appears as amorphous, fluffy or granular material within dilated cisternae of the rough endoplasmic reticulum. This finding suggests intracellular storage possibly reflecting a defective intracellular transport of fibrinogen.

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