1981
DOI: 10.1007/bf01308373
|View full text |Cite
|
Sign up to set email alerts
|

Hepatic morphology in obesity

Abstract: Changes in hepatic morphology were evaluated in 242 consecutive liver biopsy specimens obtained from nonalcoholic obese subjects. Steatosis occurred in 59.7% of the subjects but was moderate to severe in 28.7%. An alcoholic hepatitis-like picture was present in 8.7% and cirrhosis in 2.7%. Fibrosis of mild and moderate degrees was encountered in 26.1% and 5.8%, respectively. This study indicates that the histopathological changes that occur in the livers of obese subjects are similar to alcoholic liver injury.

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1
1
1

Citation Types

1
20
0
6

Year Published

1989
1989
2005
2005

Publication Types

Select...
8
1

Relationship

0
9

Authors

Journals

citations
Cited by 79 publications
(28 citation statements)
references
References 11 publications
1
20
0
6
Order By: Relevance
“…The observation that some obese individuals presented a liver disease histologically indistinguishable from alcoholic liver disease itself had long been recognized. [42][43][44][45][46][47][48][49] Interestingly, it has been recently demonstrated that obesity also increases the risk of liver disease induced by either alcohol 50 or chronic hepatitis C. [51][52][53] In a literature survey of 41 original articles comprising information on liver morphology in 1515 morbidly obese patients, liver biopsy was considered as normal in only 12% of the cases. 54 The most frequent abnormality reported was fatty changes present in 80% of the biopsies; portal inflammation was also common (33%) while portal or periportal fibrosis was observed in 29%.…”
Section: The Association Of Nash With Obesitymentioning
confidence: 99%
“…The observation that some obese individuals presented a liver disease histologically indistinguishable from alcoholic liver disease itself had long been recognized. [42][43][44][45][46][47][48][49] Interestingly, it has been recently demonstrated that obesity also increases the risk of liver disease induced by either alcohol 50 or chronic hepatitis C. [51][52][53] In a literature survey of 41 original articles comprising information on liver morphology in 1515 morbidly obese patients, liver biopsy was considered as normal in only 12% of the cases. 54 The most frequent abnormality reported was fatty changes present in 80% of the biopsies; portal inflammation was also common (33%) while portal or periportal fibrosis was observed in 29%.…”
Section: The Association Of Nash With Obesitymentioning
confidence: 99%
“…Consistent with the results of other studies [11,13] , our results revealed that a larger BMI and a more-substantial waist circumference were both highly associated with an elevated serum ALT level. Previous studies have indicated that most obese individuals who featured an elevated serum ALT level did suffer from steatosis without any associated hepatic fibrotic reactions or sites of inflammation upon liver biopsy [17,18] . Further, approximately 30% of obese adults, who exhibited an elevated serum aminotransferase level, exhibited steatohepatitis associated with fibrosis or cirrhosis as demonstrated upon liver biopsy [17,18] , approximately 40% of these cases revealed progressive liver disease [19] .…”
Section: Implications Of Gender Difference As Regards Associated Riskmentioning
confidence: 99%
“…Previous studies have indicated that most obese individuals who featured an elevated serum ALT level did suffer from steatosis without any associated hepatic fibrotic reactions or sites of inflammation upon liver biopsy [17,18] . Further, approximately 30% of obese adults, who exhibited an elevated serum aminotransferase level, exhibited steatohepatitis associated with fibrosis or cirrhosis as demonstrated upon liver biopsy [17,18] , approximately 40% of these cases revealed progressive liver disease [19] . In addition to such a finding, a larger waist circumference was also reported to be more strongly related to an elevated serum ALT level than was the case for an elevated BMI level for this last-mentioned study [19] .…”
Section: Implications Of Gender Difference As Regards Associated Riskmentioning
confidence: 99%
“…Obesity is an important risk factor in pathophysiology of NAFLD, cirrhosis-associated death (10) and liver cell cancer (11). In many cases NAFLD is histologically indistinguishable from alcoholic liver disease (12)(13)(14)(15)(16). Many NAFLD patients having liver fibrosis may be subject to cirrhosis and its complications (15)(16)(17).…”
Section: Effects Of High Fat Diet Induced Obesity On Female Rat Livermentioning
confidence: 99%