2023
DOI: 10.1186/s12885-023-10912-4
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Hepatic passaging of NRAS-mutant melanoma influences adhesive properties and metastatic pattern

Abstract: Background Liver metastasis is a poor prognostic factor for treatment of advanced cutaneous melanoma with either immunotherapy or targeted therapies. In this study we focused on NRAS mutated melanoma, a cohort with high unmet clinical need. Methods WT31 melanoma was repeatedly passaged over the liver after intravenous injections five times generating the subline WT31_P5IV. The colonization of target organs, morphology, vascularization and the gene … Show more

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