Hepatic perfusion after liver transplantation: noninvasive measurement with dynamic single-section CT.

Bader, Till R.; Herneth, Andreas M.; Blaicher, W.; Steininger, R.; Mühlbacher, F.; Lechner, G; F, Grabenwöger

doi:10.1148/radiology.209.1.9769823

Cited by 59 publications

(37 citation statements)

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“…A summary of some of the previous imaging protocols used in liver DCE CT studies involving human subjects is provided in Table 5. We note that in order to assess liver perfusion by using the ratio of maximum tissue gradient to arterial peak method [15,16,[20][21][22][23][24][25], imaging the liver up to about 80 s would be adequate since the aim is to estimate the slope of initial 1191 Fig. 3 a Contrast-enhanced CT image of patient 3 at 36 s after bolus injection.…”

Section: Discussionmentioning

confidence: 99%

Dynamic contrast-enhanced CT imaging of hepatocellular carcinoma in cirrhosis: feasibility of a prolonged dual-phase imaging protocol with tracer kinetics modeling

et al. 2009

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Dynamic contrast-enhanced (DCE) CT imaging of four patients with hepatocellular carcinoma (HCC) was performed using a dual-phase imaging protocol designed with initial rapid dynamic imaging to capture the initial increase in contrast medium enhancement in order to assess perfusion, followed by a delayed imaging phase with progressively longer intervals to monitor subsequent tissue enhancement behaviour in order to assess tissue permeability. The DCE CT images were analysed using a dual-input two-compartment distributed parameter model to yield separate estimates for blood flow and permeability, as well as fractional intravascular and extravascular volumes. The HCCs and surrounding cirrhotic liver tissues were found to exhibit enhancement curves that can be appropriately described by two distinct compartments separated by a semipermeable barrier. Early contrast arrival was also found for HCC as compared with background liver. These findings are consistent with the current understanding of sinusoidal capillarization and hepatocarcinogenesis.

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Section: Discussionmentioning

confidence: 99%

Dynamic contrast-enhanced CT imaging of hepatocellular carcinoma in cirrhosis: feasibility of a prolonged dual-phase imaging protocol with tracer kinetics modeling

et al. 2009

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“…Quantification of hepatic blood flow may prove useful to assess liver metastases, chronic liver diseases, and liver graft rejection (11)(12)(13), and to study the systemic availability of drugs in health and diseases (40). In addition, as previously reported mainly in ex vivo studies with the multiple-indicator dilution technique (2,3), assessment of hepatic perfusion parameters such as the distribution volume and the mean transit time may prove useful to evaluate the sinusoidal permeability changes in cirrhosis.…”

Section: Discussionmentioning

confidence: 99%

“…Dynamic CT has been proposed to quantify hepatic perfusion from first-pass analysis of extravascular contrast agents (10). CT has been used in preliminary studies to quantify perfusion abnormalities in liver metastases, chronic liver diseases, and liver graft rejection (11)(12)(13).…”

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confidence: 99%

Assessment of hepatic perfusion parameters with dynamic MRI

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Smith

Peeters

et al. 2001

Magnetic Resonance in Med

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“…The VHS technique can be used for perfusion studies of the liver and for 4D CT angiography. Liver perfusion CT has generally been performed for a single section [4,32,33]. However, the high temporal resolution of VHS scanning enables whole liver perfusion imaging with multisections.…”

Section: Ct Imagingmentioning

confidence: 99%

Ultrasonography, Computed Tomography and Magnetic Resonance Imaging of Hepatocellular Carcinoma: Toward Improved Treatment Decisions

et al. 2011

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Detection, characterization, staging, and treatment monitoring are major roles in imaging diagnosis in liver cancers. Contrast-enhanced ultrasonography (CEUS) using microbubble contrast agents has expanded the role of US in the detection and diagnosis of liver nodules in patients at high risk of hepatocellular carcinoma (HCC). CEUS provides an accurate differentiation between benign and malignant liver nodules, which is critical for adequate management of HCC and is also useful for guidance of percutaneous local therapy of HCC and postprocedure monitoring of the therapeutic response. The technology of multidetector-row computed tomography (MDCT) has increased spatial and temporal resolutions of computed tomography (CT). It has made possible a more precise evaluation of the hemodynamics of liver tumor, and the diagnostic accuracy of dynamic MDCT has improved. Perfusion CT can measure tissue perfusion parameters quantitatively and can assess segmental hepatic function. Dynamic MDCT with high spatial and temporal resolution enables us to reconstruct 3- and 4-dimensional imaging, which is very useful for pretreatment evaluation. Dual-energy CT makes possible the differentiation of materials and tissues in images obtained based on the differences in iodine and water densities. Monochromatic images, which can be reconstructed by dual-energy CT data, provide some improvement in contrast and show a higher contrast-to-noise ratio for hypervascular HCCs. Dynamic magnetic resonance imaging with fast imaging sequence of 3-dimensional Fourier transformation T₁-weighted gradient echo and nonspecific contrast medium can show high detection sensitivity of hypervascular HCC. However, the hepatic tissue-specific contrast medium, gadolinium-ethoxybenzyl-diethylenetriamine pentaacetic acid, has become an essential contrast medium for liver imaging because of its higher diagnostic ability. It may replace CT during hepatic arteriography and during arterioportography.

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Hepatic perfusion after liver transplantation: noninvasive measurement with dynamic single-section CT.

Cited by 59 publications

References 0 publications

Dynamic contrast-enhanced CT imaging of hepatocellular carcinoma in cirrhosis: feasibility of a prolonged dual-phase imaging protocol with tracer kinetics modeling

Dynamic contrast-enhanced CT imaging of hepatocellular carcinoma in cirrhosis: feasibility of a prolonged dual-phase imaging protocol with tracer kinetics modeling

Assessment of hepatic perfusion parameters with dynamic MRI

Ultrasonography, Computed Tomography and Magnetic Resonance Imaging of Hepatocellular Carcinoma: Toward Improved Treatment Decisions

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