Hepatic Perivascular Epithelioid Cell Tumor Mimicking Hepatocellular Carcinoma

Harwal, Rahul; Rosemary, Livin Jose Joseph; Raju, Prabhakaran; Chidambaranathan, Sugumar; Jayanthi, J Bharathi Vidya; Lakshmanamoorthy, Naganath Babu Obla

doi:10.14309/crj.0000000000000962

Cited by 2 publications

(2 citation statements)

References 16 publications

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“…Therefore, they may show intense contrast enhancement and close vessel relationship, especially in contrast phases. 19,20 In the study of Gao et al, "large blood vessel" was observed in approximately 80% of liver PEComas. 21 In our case, the mass was observed to be associated with the right portal vein branch (►Fig.…”

Section: Discussionmentioning

confidence: 99%

Very Rare Liver Tumor: PEComa Case Report with and a Review of Literature

Yazıcı,

Gündoğdu

2023

Indian J Radiol Imaging

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Perivascular epithelioid cell tumors (PEComas) are very rare mesenchymal tumors. In addition to being rare in general, they are even rarer in the liver. There are various subtypes and there is only one case of liver PEComa reported in the clear cell type in the literature to date. We present the second clear cell type liver PEComa in this case by reviewing the literature data. The hypodense, smooth-edged, ovoid lesion was detected on computed tomography (CT) for performing abdominal pain in a 41-year-old female patient. Magnetic resonance imaging (MRI) was then performed for lesion characterization. The lesion was hypointense on T1-weighted imaging (T1WI), hyperintense on T2-weighted imaging (T2WI). In dynamic phases, it showed marked enhancement on the arterial phase and capsular enhancement with central washout on the portal and late venous phases. The posterior branch of the right portal vein extended into the mass. The lesion was excised and the pathological result was epithelioid clear cell subtype of PEComa. Although the imaging findings are generally nonspecific and certain diagnosis is made histopathologically, radiologists should consider PEComa in the differential diagnosis in the presence of intensely enhanced lesion on the right lobe in female patients. Also, the “large vessel sign” may help in the diagnosis.

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Section: Discussionmentioning

confidence: 99%

Very Rare Liver Tumor: PEComa Case Report with and a Review of Literature

Yazıcı,

Gündoğdu

2023

Indian J Radiol Imaging

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“…The following are available online at , Table S1: Published cases of primary liver PEComas. References [ 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 , 52 , 53 , 54 , 55 , 56 , 57 , 58 , 59 , 60 , 61 , 62 , 63 , 64 , 65 , 66 , 67 , 68 , 69 , 70 , 71 , 72 , 73 , 74 , 75 , 76 , 77 , 78 , 79 , ...…”

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Primary Liver Perivascular Epithelioid Cell Tumor (PEComa): Case Report and Literature Review

Kvietkauskas,

Samuolyte,

Rackauskas

et al. 2024

Medicina

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A primary liver perivascular epithelioid cell tumor (PEComa) is an extremely rare entity. In this article, we present a case report with a review of the literature on the patients diagnosed with primary liver PEComa and an elaboration of diagnostic and treatment modalities. A systematic literature search was conducted using the terms “perivascular epithelioid cell tumor”, “PEComa”, “liver”, and “hepatic”. All articles describing patients diagnosed with primary liver PEComa were included. We identified a total of 224 patients of primary liver PEComa from 75 articles and a case from the present study with a significant preponderance of females (ratio 4:1) and with a mean age of 45.3 ± 12.1 years. Most of the patients (114 out of 224, 50.9%) were asymptomatic. A total of 183 (81.3%) patients underwent surgical hepatic resection at the time of diagnosis, while 19 (8.4%) underwent surveillance. Recurrence and metastases were detected in seven (3.1%) and six (2.7%) patients, respectively. In conclusion, surgical resection remains the cornerstone of therapy; however, the presence of nonspecific imaging features makes it difficult to reach a definite diagnosis preoperatively. Therefore, a multidisciplinary approach should be the gold standard in selecting the treatment modality.

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Hepatic Perivascular Epithelioid Cell Tumor Mimicking Hepatocellular Carcinoma

Cited by 2 publications

References 16 publications

Very Rare Liver Tumor: PEComa Case Report with and a Review of Literature

Very Rare Liver Tumor: PEComa Case Report with and a Review of Literature

Primary Liver Perivascular Epithelioid Cell Tumor (PEComa): Case Report and Literature Review

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