2023
DOI: 10.1016/j.celrep.2022.111940
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Hepatic phosphatidylcholine catabolism driven by PNPLA7 and PNPLA8 supplies endogenous choline to replenish the methionine cycle with methyl groups

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Cited by 16 publications
(36 citation statements)
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“…The amino acid sequences of PNPLA6 and PNPLA7 are ~60% identical, with the N-terminal side facing the endoplasmic reticulum (ER) across the transmembrane domain and the C-terminal side including the catalytic patatin domain facing the cytosol ( Figure 1 ). PNPLA7 displays lysophospholipase activity, hydrolyzing the sn -1 or sn -2 ester of LPC, although it does not catalyze the hydrolysis of PC via PLA 1 /PLA 2 activity [ 13 , 14 ]. Both PNPLA6 and PNPLA7 are widely expressed in various tissues, with PNPLA6 being abundantly expressed in the central nervous system and PNPLA7 in metabolically active tissues including skeletal muscle, liver, and adipose tissue [ 14 ].…”
Section: Properties Of Pnpla7 the Closest Paralog Of Pnpla6mentioning
confidence: 99%
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“…The amino acid sequences of PNPLA6 and PNPLA7 are ~60% identical, with the N-terminal side facing the endoplasmic reticulum (ER) across the transmembrane domain and the C-terminal side including the catalytic patatin domain facing the cytosol ( Figure 1 ). PNPLA7 displays lysophospholipase activity, hydrolyzing the sn -1 or sn -2 ester of LPC, although it does not catalyze the hydrolysis of PC via PLA 1 /PLA 2 activity [ 13 , 14 ]. Both PNPLA6 and PNPLA7 are widely expressed in various tissues, with PNPLA6 being abundantly expressed in the central nervous system and PNPLA7 in metabolically active tissues including skeletal muscle, liver, and adipose tissue [ 14 ].…”
Section: Properties Of Pnpla7 the Closest Paralog Of Pnpla6mentioning
confidence: 99%
“…PNPLA7 displays lysophospholipase activity, hydrolyzing the sn -1 or sn -2 ester of LPC, although it does not catalyze the hydrolysis of PC via PLA 1 /PLA 2 activity [ 13 , 14 ]. Both PNPLA6 and PNPLA7 are widely expressed in various tissues, with PNPLA6 being abundantly expressed in the central nervous system and PNPLA7 in metabolically active tissues including skeletal muscle, liver, and adipose tissue [ 14 ]. Expression of PNPLA7, but not PNPLA6, is upregulated in the liver and adipose tissue during fasting, suggesting its nutritional regulation [ 14 ].…”
Section: Properties Of Pnpla7 the Closest Paralog Of Pnpla6mentioning
confidence: 99%
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