Hepatic Reactions to Tetracycline

Complications of Tetracycline Therapy

“…However, lower doses may be in order when possible the serum concentration should be moni¬ tored, and other potentially hepatotoxic drugs should not be prescribed concomitantly. 28 Sixth, as with any other potent drug, control of administration of tetracycline should be in the hands of the physician at all times. This precludes the writing of the prescription in such a manner that it may be refilled indefinitely by the patient.…”

Antibiotics in pregnancy: Toxicity and teratogenicity

“…Furthermore, the occurrence of congenital limb malformations due to tetracyclines has been discussed (19). Severe adverse effects, such as lethal fatty liver degeneration, were reported in pregnant women undergoing tetracycline therapy (often after a high dosage) (20,21). The danger of side-effects with respect to the mother is probably greatest during the last trimester of pregnancy.…”

Drug-Induced Diseases

“…The second type of liver injury arises from a cholestatic effect which has been reported after a large number of drugs: e.g., tetracyclines, phenothia zines, methyltestosterone, norethisterone, norethandrolone (Nilevar), sulfa diazine, thiouracil, arsphenamine, chlorpropamide (Diabinese), para-amino salicylic acid, carbarsone, many of the antineoplastic drugs, and others (41,44,74). The mechanism of the stasis is not understood.…”

“…Fatty changes in the liver after tetracyclines which do not fit into the categories listed above have been reported (41). (19,54), and a number of other drugs has been established (60).…”