Hepatic Resection Combined with Intraoperative Radiofrequency Ablation Versus Hepatic Resection Alone for Selected Patients with Moderately Advanced Multifocal Hepatocellular Carcinomas

Zheng, Kejie; Liao, Anque; Yan, Lü-Nan; Yang, Jiayin; Wen, Tianfu; Wang, Wentao; Li, Bo; Wu, Hong; Jiang, Li

doi:10.1245/s10434-022-11757-0

Cited by 2 publications

(1 citation statement)

References 33 publications

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“…RFA has been widely used as a minimally invasive surgical procedure for patients with primary or secondary liver malignancies. Ultrasound-guided RFA combined with experienced manipulators could achieve similar oncological outcomes and long-term survival as conventional partial hepatectomy in cases with small liver tumors, avoiding unnecessary surgery-related trauma to human body, which has been validated by Zheng et al 17 Moreover, due to the survival benefit brought by adjuvant systematic chemotherapy, the prognosis of patients with colorectal metastatic liver disease has greatly improved, with a reported 5-year survival rate reaching 60%. 5 However, as for GBC patients with liver metastasis, their prospect still seems to be vague.…”

Section: Discussionmentioning

confidence: 92%

The significance of countable and treatable metastatic liver disease in patients with gallbladder carcinoma after curative‐intent surgery: A 10‐year experience in China

et al. 2023

Cancer Medicine

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ObjectiveOur study was performed to evaluate the significance of countable and treatable metastatic liver disease (CTMLD) in patients with gallbladder carcinoma (GBC) after curative‐intent surgery.MethodsResected GBC patients between September 2010 and January 2021 were reviewed. Comparative analyses between patients with CTMLD and those without it were performed. A propensity score matching analysis was conducted for further validation.ResultsA total of 326 resected GBC patients were identified (33 with CTMLD). A significantly higher preoperative CA199 level was detected in those with CTMLD (p = 0.0160). Significantly higher incidences of major hepatectomy (p = 0.0010), lymph node metastasis (p < 0.0001), direct liver invasion (p < 0.0001), moderate to poor differentiation status (p < 0.0001), and T3–4 disease (p < 0.0001) were detected in patients with CTMLD. Even sharing comparable surgical margin status, patients with CTMLD still shared a significantly higher recurrence rate (93.9% vs. 57.3%, p < 0.0001) as well as a significantly higher recurrence rate within 6 months after surgery (63.6% vs. 14.7%, p < 0.0001). A significantly worse overall survival (median survival time: 12 vs. 33 months, p < 0.0001) or disease‐free survival (median recurrence‐free time: 6 vs. 30 months, p < 0.0001) was acquired in patients with CTMLD. After matching, a significantly higher early recurrence rate was still detected. Adjuvant chemotherapy seemed to have survival benefit for patients with CTMLD.ConclusionCTMLD was an indicator of advanced disease and served as an independent predictor of early recurrence among resected GBC patients. Whether curative‐intent surgery is superior to nonsurgical treatment among GBC patients with CTMLD remains to be explored in future prospective studies.

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Section: Discussionmentioning

confidence: 92%

The significance of countable and treatable metastatic liver disease in patients with gallbladder carcinoma after curative‐intent surgery: A 10‐year experience in China

et al. 2023

Cancer Medicine

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ASO Author Reflections: How to Choose the Optimal Strategy to Treat Patients with Moderately Advanced Multifocal Hepatocellular Carcinomas?

et al. 2022

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Hepatic Resection Combined with Intraoperative Radiofrequency Ablation Versus Hepatic Resection Alone for Selected Patients with Moderately Advanced Multifocal Hepatocellular Carcinomas

Cited by 2 publications

References 33 publications

The significance of countable and treatable metastatic liver disease in patients with gallbladder carcinoma after curative‐intent surgery: A 10‐year experience in China

The significance of countable and treatable metastatic liver disease in patients with gallbladder carcinoma after curative‐intent surgery: A 10‐year experience in China

ASO Author Reflections: How to Choose the Optimal Strategy to Treat Patients with Moderately Advanced Multifocal Hepatocellular Carcinomas?

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