Hepatic sinusoidal endothelial cells

Hepatic sinusoids in liver injury, inflammation, and fibrosis: new pathophysiological insights

“…Through this mechanism known as autoregulation, hepatic sinusoids can adapt to increased intrahepatic blood flow and decrease intrahepatic pressure [8]. Further physiological functions of SEC are leukocyte diapedesis through expression of adhesion molecules, endocytosis (known as the hepatic reticuloendothelial system), and bacterial processing [5]. As the first cells interacting with portal vein components, SEC are exposed to different bacterial compounds.…”

“…SEC have a very unique phenotype distinct from conventional endothelial cells, characterized by multiple fenestrae and the lack of a basement membrane [3][4][5]. Serving as a mechanical sieve, fenestration permits steric selection of transfer from sinusoidal space to hepatic parenchyma [6,7].…”