Hepatic Sinusoidal Obstruction Syndrome in Patients Undergoing Hematopoietic Stem Cell Transplant

Eisenberg, Seth

doi:10.1188/08.onf.385-397

Cited by 11 publications

(20 citation statements)

References 111 publications

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“…The first step is symptomatic treatment with supportive care, which traditionally has been a crucial part of the treatment plan (1,11,27,39,40), and nurses play a key role in providing this (11).…”

Section: Curative Treatmentmentioning

confidence: 99%

Management of veno‐occlusive disease: the multidisciplinary approach to care

Wallhult

Kenyon

Liptrott

et al. 2017

European J of Haematology

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Although it is considered a relatively rare disorder, veno-occlusive disease (VOD) is one of the main causes of overall, non-relapse mortality associated with haematopoietic stem cell transplantation (HSCT). This article, based on the consensus opinion of haemato-oncology nurses, haemato-oncologists and pharmacists from both adult and paediatric services at the VOD International Multi-Disciplinary Advisory Board at the European Society for Blood and Marrow Transplantation (EBMT) meeting, Istanbul, 2015, aims to explore the multidisciplinary approach to care for the management of VOD, with an emphasis on current challenges in this area. The careful monitoring of HSCT patients allows early detection of the symptoms associated with VOD and timely treatment, ultimately improving patient outcomes. As part of a multidisciplinary team, nurses have an essential role to play, from pretransplant assessment to medical management and overall care of the patient. Physicians and pharmacists have a responsibility to facilitate education and training so that nurses can work effectively within that team.

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Section: Curative Treatmentmentioning

confidence: 99%

Management of veno‐occlusive disease: the multidisciplinary approach to care

Wallhult

Kenyon

Liptrott

et al. 2017

European J of Haematology

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“…Early recognition, diagnosis and treatment are crucial aspects to limit SOS' severity increasing chances of success [22][23][24][25]. Some authors state that nurses should be involved in a pre-transplant risk assessment to optimize risk factor detection and that they have a crucial role in the early detection of signs and symptoms during and after hospitalization [26][27][28][29][30][31][32][33]. Many clinical issues have been investigated; nursing issues have been studied as well, but there is a lack of specific topics such as assessment, monitoring techniques and care standards.…”

Section: Introductionmentioning

confidence: 99%

Nursing role in the assessment and care of hepatic sinusoidal obstruction syndrome patients: a consensus paper by the “Gruppo Italiano Trapianto di Midollo Osseo”

Botti

Agreiter

Orlando

et al. 2020

Support Care Cancer

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Purpose Sinusoidal obstruction syndrome (SOS) is one of the most serious complications post haematopoietic stem cell transplantation (HSCT). The diagnosis of SOS is clinical, but nurses should be involved in the pre-transplant risk assessment period and play a crucial role in the early detection of signs and symptoms during and after hospitalization. The aim of this work is to achieve a consensus on nurses' behaviour in caring for SOS. Methods On behalf of the Italian Group for Bone and Marrow Transplantation (GITMO), a promoter committee was established to put in place a consensus conference approach. A multidisciplinary group of GITMO together with four nurses, three haematology physicians and one patient representative acted as jury, who reviewed the reports and wrote recommendations and suggestions. Recommendations gaining 100% of consensus were considered 'Golden Points of Care'; if a consensus was achieved by ≥ 75% of the jury's members, those recommendations were defined as 'Good Practices'. Results Eighteen papers written by nurses as first authors have been identified. Golden Points of Care and Good Practices were worked out for the following topics: nurses' role in general, nurses' role in pre-transplant assessment, pre-transplant risk assessment and risk stratification, baseline monitoring, suspected mild or moderate SOS, suspected severe or very severe SOS and late-onset cases. Conclusion SOS is relatively rare; therefore, a holistic approach to the patients' needs considering nursing role as essential may result in better care outcomes.

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“…2,3 The incidence of SOS following stem cell transplantation ranges from 5% to 70% according to various reports, 2 but has been decreased to 30% or less with the advent of nonmyeloablative conditioning and avoidance of cyclophophamide in myeloablative regimens. 3,4 Most patients with mild or moderate SOS will recover. However, severe SOS carries a grave prognosis and typically runs a fulminant clinical course with acute liver failure, coagulopathy, and hepatorenal syndrome.…”

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confidence: 99%

“…Some of these observations have led to pharmacological interventions involving low-dose heparin, AT III replacement, prostaglandin E1, recombinant tissue plasminogen activator, N-acetylcysteine, or defibrotide. 4 Among these agents, defibrotide, a mixture of porcine-derived phosphodiester oligonucleotides, has been suggested to show promise for the prevention and treatment of SOS. 6 Since SOS contributes to considerable morbidity and mortality, further understanding of its pathogenesis and development of therapeutic or preventive strategies are required.…”

mentioning

confidence: 99%

“…These can be broadly classified into blood panels (biomarkers), and physical modalities that provide a measure of liver stiffness. 4,5 Initially developed as a non-invasive marker of liver fibrosis in patients with chronic hepatitis C, Transient elastography (TE) using a Fibroscan (Echosense, Paris, France) is rapidly gaining favour as simple, non-invasive, reliable and reproducible modality for the assessment of a wider range of chronic liver diseases. It is also readily accepted by patients for repeated measurements.…”

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confidence: 99%

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