Hepatic steatosis assessment with CT or MRI in patients with colorectal liver metastases after neoadjuvant chemotherapy

Marsman, Hendrik A.; Pool, A.E. van der; Verheij, Joanne; Padmos, J.; Kate, Fiebo J.W. ten; Dwarkasing, Roy S.; Gulik, Thomas M. van; IJzermans, Jan N.M.; Verhoef, Cornelis

doi:10.1002/jso.21874

Cited by 15 publications

(7 citation statements)

References 31 publications

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“…Positron emission tomography/computed tomography have a higher accuracy for detection of extra-hepatic and colorectal liver metastases than computed tomography alone (Patel et al, 2011). In patients treated with neoadjuvant chemotherapy, magnetic resonance imaging measurements of steatosis show the highest correlation coefficient and the best diagnostic accuracy, as compared to computed tomography ones (Marsman et al, 2011). Intraoperative ultrasound and preoperative imaging significantly increase the diagnostic accuracy of patients undergoing liver resection for colorectal liver metastases (Lordan et al, 2011).…”

Section: Discussionmentioning

confidence: 99%

Resection for Colorectal Liver Metastases

Kostov¹,

Kobakov²

2012

Colorectal Cancer - From Prevention to Patient Care

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Section: Discussionmentioning

confidence: 99%

Resection for Colorectal Liver Metastases

Kostov¹,

Kobakov²

2012

Colorectal Cancer - From Prevention to Patient Care

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“…It is important to identify patients with a compromised liver in order to interpret the volumetry results correctly [11]. This has become even more important since many patients are now presented for resection after extensive induction or neoadjuvant chemotherapy, whereby liver parenchyma can be injured by postchemotherapy steatosis or veno-occlusive disease [12]. In the absence of preoperative biopsies, parenchymal damage or disease is often elusive until after the resection specimen has been examined.…”

Section: Volumetric Measurement Techniques: the Gold Standard And Novmentioning

confidence: 99%

New Perspectives in the Assessment of Future Remnant Liver

Cieslak¹,

Runge

Heger³

et al. 2014

Dig Surg

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In order to achieve microscopic radical resection margins and thus better survival, surgical treatment of hepatic tumors has become more aggressive in the last decades, resulting in an increased rate of complex and extended liver resections. Postoperative outcomes mainly depend on the size and quality of the future remnant liver (FRL). Liver resection, when performed in the absence of sufficient FRL, inevitably leads to postresection liver failure. The current gold standard in the preoperative assessment of the FRL is computed tomography volumetry. In addition to the volume of the liver remnant after resection, postoperative function of the liver remnant is directly related to the quality of liver parenchyma. The latter is mainly influenced by underlying diseases such as cirrhosis and steatosis, which are often inaccurately defined until microscopic examination after the resection. Postresection liver failure remains a point of major concern that calls for accurate methods of preoperative FRL assessment. A wide spectrum of tests has become available in the past years, attesting to the fact that the ideal methodology has yet to be defined. The aim of this review is to discuss the current modalities available and new perspectives in the assessment of FRL in patients scheduled for major liver resection. i 2014 S. Karger AG, Basel

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“…Systemic chemotherapy contributes to reduce risk of recurrence after resection [4], facilitates the resection of lesions initially not suitable for resection [5,6] and improves survival of patients with unresectable liver metastases [7]. However, chemotherapy results in a variety of side effects on the liver parenchyma such as steatosis, steatohepatitis, and sinusoidal obstruction syndrome (SOS) [8], which are associated with higher morbidity and mortality after liver resection [9][10][11]. Therefore, considering the high cost and hepatic toxicity of chemotherapies, prediction of treatment response before chemotherapy is not only a clinical necessity, but also an economic requirement.…”

Section: Introductionmentioning

confidence: 99%