Hepatic steatosis, body mass index and long term outcome in patients undergoing hepatectomy for colorectal liver metastases

Abstract

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Differential impact of obesity and diabetes mellitus on survival after liver resection for colorectal cancer metastases

“…In patients with CRC liver metastases undergoing liver resection, patient survival has been shown to be unrelated to obesity [3], overweight, or central adiposity [24] in two previous studies. However, no adjustment for confounders was performed in one of these reports [3], whereas the potential role only of overweight (BMI 25 kg/m 2 ) and central adiposity, but not specifically obesity, was explored in the other [24].…”

“…Data on the impact of obesity on survival after liver resection for CRC metastases are very limited. Although overall survival has been shown to be prolonged with increasing body mass index (BMI) after hepatectomy for various types of cancer [2], this was not confirmed in a recent study in patients undergoing liver resection due to CRC metastases [3]. Finally, diabetes mellitus is frequent in obesity and may have a negative impact on oncologic outcomes in CRC [15], but data on its potential effect on survival after liver resection for CRC metastases are scarce.…”

Vascular Endothelial Growth Factor Improves Liver Regeneration and Survival after 90% Hepatectomy in a Rat Model of Diet-Induced Steatosis

“…This is of particular relevance as it is estimated that hepatic steatosis is present in more than 20% of patients with a planned liver resection or liver transplantation [17,18]. The adverse effects of steatosis in liver surgery have been associated with increased postoperative morbidity and mortality due to a higher risk of impaired liver regeneration and liver dysfunction.…”

“…The adverse effects of steatosis in liver surgery have been associated with increased postoperative morbidity and mortality due to a higher risk of impaired liver regeneration and liver dysfunction. Even the mildest form of steatosis increases the incidence of postoperative morbidity and mortality after liver resection or liver transplantation despite the fact that this organ has a profound capacity for regeneration [10,17,18,19,20]. …”

“…It is known that this entity is associated with increased mortality and morbidity after liver resection [16]. Thus, therapeutic strategies to improve regeneration and functional recovery of the remnant liver are very important in these patients [17,18]. As is not known whether VEGF and EPO may improve the outcome in these individuals, we examined the influence of these mediators on hepatocellular recovery and liver regeneration after 90% hepatectomy in a rat model of diet-induced steatosis.…”