Hepatic steatosis provides the terroir that promotes the development of cardiovascular risk factors and disease

Multilevel Screening Strategy to Identify the Hydrophobic Organic Components of Ambient PM2.5 Associated with Hepatocellular Steatosis

“…However, there might also be numerous novel organic pollutants, either known or unknown, in PM 2.5 that contribute to hepatic steatosis. Among the 17 components identified herein, most were organic esters (10), mainly comprising phthalates, phthalate substitutes, organophosphates, and other plastic additives. Moreover, we identified two aromatic compounds, two pyridine derivatives, two organic alcohols, and one amide compound, all of which were associated with cellular lipid accumulation.…”

“…8,9 Hepatic steatosis is the initial phenotype of NAFLD and provides the environment that promotes the development of diabetes and cardiovascular diseases. 10 The association between PM 2.5 exposure and NAFLD has been reported by numerous epidemiological studies. 6,11,12 Furthermore, extensive evidence suggests that exposure to PM 2.5 from various regions has been linked to increased hepatic triglyceride (TG) levels, steatosis, and NAFLD-like phenotypes in rodent models.…”

“…The prevalence of NAFLD is as high as 25% globally and 29.2% in China, which continues to increase parallelly. , Hepatic steatosis is the initial phenotype of NAFLD and provides the environment that promotes the development of diabetes and cardiovascular diseases . The association between PM 2.5 exposure and NAFLD has been reported by numerous epidemiological studies. ,, Furthermore, extensive evidence suggests that exposure to PM 2.5 from various regions has been linked to increased hepatic triglyceride (TG) levels, steatosis, and NAFLD-like phenotypes in rodent models. − Although these studies have reported a strong association between PM 2.5 and NAFLD or hepatic steatosis, the sources or components of PM 2.5 lead to substantial differences in the adverse effects caused by them.…”