Hepatic Stem Cells and Liver Development

Navarro-Alvarez, Nalú; Soto-Gutiérrez, Alejandro; Kobayashi, Naoya

doi:10.1007/978-1-60327-227-8_34

Cited by 4 publications

(4 citation statements)

References 227 publications

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“…However, these models do not fully recapitulate the simultaneous differentiation of liver progenitors to the hepatocytic and biliary fates and the formation of liver with these two tissues present. The generation of bona fide mature bile ducts is especially difficult in vitro and requires the presence of a 3D environment for efficient cellular polarization and organization . Scaffolds made from liver ECM were shown to possess the 3D environment that can guide differentiation and maturation of human liver progenitors .…”

Section: Discussionmentioning

confidence: 99%

Self‐assembled liver organoids recapitulate hepatobiliary organogenesis in vitro

et al. 2018

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Section: Discussionmentioning

confidence: 99%

Self‐assembled liver organoids recapitulate hepatobiliary organogenesis in vitro

et al. 2018

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“…Stem cells are critically involved in liver ontogenesis (reviews: Kamiya et al 2006;Navarro-Alvarez et al 2010). After fating of primordial endodermal cells to become liver, hepatic specification produces bipotential hepatic stem cells or hepatoblasts which can differentiate into either hepatocytes or cholangiocytes (reviews: Sangan and Tosh 2010;Parveen et al 2011;Shin and Monga 2013;Kamiya and Inagaki 2015).…”

Section: Stem Cells and Progenitor Cells In The Normal Liver: Pacemakmentioning

confidence: 99%

Liver Cancer: Stem and Progenitor Cells

Zimmermann¹

2016

Tumors and Tumor-Like Lesions of the Hepatobiliary Tract

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Stem cells are involved in hepatocarcinogenic pathways. In the normal liver, hepatic stem cells are self-renewing cells dwelling in distinct compartments termed stem cell niches. These niches are distinct microenvironments which maintain the balance of slow selfrenewal of quiescent stem cells and their priming to become hepatocytes and other differentiated cells. Hepatic stem cells possess plasticity, allowing them to undergo lineage diversification. In hepatocarcinogenesis, tumor stem cells mimick certain features of their normal counterparts. Tumor stem cells in hepatocellular carcinoma (HCC) can act as tumor-initiating cells and tumor-propagating cells that express hepatic stem cell markers and show distinct gene expression profiles. Apart from their role in carcinogenic pathways, cancer stem cells in HCC are considered to play an important role in tumor recurrence and metastasis. The expression of stemnessrelated markers in HCC confers an aggressive phenotype in these neoplasms. Tumor stem cells in HCC modulate several processes, including maintenance of slowly cycling clonogenic cells having longevity, induction of distinct growth features, and tumor progression. Following removal of HCC and other liver cancers, tumor stem cells can remain in the liver and enter the bloodstream to settle in new stem cell niches, including metastatic niches.

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“…The subsequent development of human embryonic stem cells cocultured with animal cells. To solve this problem, hESCs have been successfully cocultured with human (hESCs) (30,35) has since attracted much attention because of their potential application in regeneration fetal muscle and skin cells (31), adult fallopian tube epithelial cells (31), foreskin cells (1,19), and bone marrow medicine (27).…”

Section: Introductionmentioning

confidence: 99%

Human Umbilical Cord Mesenchymal Stem Cells Support Nontumorigenic Expansion of Human Embryonic Stem Cells

et al. 2012

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The expansion of pluripotent human embryonic stem cells (hESCs) requires a culture on feeder layers of mouse embryonic fibroblasts (MEFs). The culture model often causes immunogenic contaminations such as xenocarbohydrate, and inevitably forms teratoma in vivo. This study tested human umbilical cord-derived mesenchymal stem cells (HUCMSCs) as the feeder for hESCs. Wharton's jelly-derived HUCMSCs showed characteristics of MSCs and were easily maintained in a culture for over 20 passages. Under the mitomycin-inhibited HUCMSC feeder, hESCs maintained the features of embryonic stem cells (pluripotency and maintenance of normal karyotypes) after a prolonged culture of more than 20 passages. Notably, in extensive trials, no teratoma was formed in xenograft in NOD/SCID mice, but subsequent resumption of teratoma formation was noted upon transient coculturing with MEFs. Interestingly, among the four pluripotency-conferring genes, MYC and OCT4 were found to be downregulated in hESCs cocultured with HUCMSCs. Results of this study supported a nontumorigenic sustained culture of hESCs and did not form teratoma in vivo.

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Hepatic Stem Cells and Liver Development

Cited by 4 publications

References 227 publications

Self‐assembled liver organoids recapitulate hepatobiliary organogenesis in vitro

Self‐assembled liver organoids recapitulate hepatobiliary organogenesis in vitro

Liver Cancer: Stem and Progenitor Cells

Human Umbilical Cord Mesenchymal Stem Cells Support Nontumorigenic Expansion of Human Embryonic Stem Cells

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