Hepatic Transcriptome Responses in Mice (Mus musculus) Exposed to the Nafion Membrane and Its Combustion Products

Feng, Mingbao; Qu, Ruijuan; Habteselassie, Mussie Y.; Jun, Wu; Yang, Shaogui; Huang, Qingguo; Wang, Zunyao

doi:10.1371/journal.pone.0128591

Cited by 3 publications

(2 citation statements)

References 54 publications

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“…55 Over 50% of studies received ratings of medium or high confidence overall (30 out of 53). The exception was Feng et al., 56 in which the Nafion was administered as Nafion membrane. Nafion membranes are composed of and release fluoride, and the study’s internal fluoride measurements indicated that the Nafion was not absorbed.…”

Section: Resultsmentioning

confidence: 99%

Systematic Evidence Map for Over One Hundred and Fifty Per- and Polyfluoroalkyl Substances (PFAS)

Carlson

Angrish

Shirke

et al. 2022

Environ Health Perspect

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Background: Per- and polyfluoroalkyl substances (PFAS) are a large class of synthetic (man-made) chemicals widely used in consumer products and industrial processes. Thousands of distinct PFAS exist in commerce. The 2019 U.S. Environmental Protection Agency (U.S. EPA) Per- and Polyfluoroalkyl Substances (PFAS) Action Plan outlines a multiprogram national research plan to address the challenge of PFAS. One component of this strategy involves the use of systematic evidence map (SEM) approaches to characterize the evidence base for hundreds of PFAS. Objective: SEM methods were used to summarize available epidemiological and animal bioassay evidence for a set of PFAS that were prioritized in 2019 by the U.S. EPA’s Center for Computational Toxicology and Exposure (CCTE) for in vitro toxicity and toxicokinetic assay testing. Methods: Systematic review methods were used to identify and screen literature using manual review and machine-learning software. The Populations, Exposures, Comparators, and Outcomes (PECO) criteria were kept broad to identify mammalian animal bioassay and epidemiological studies that could inform human hazard identification. A variety of supplemental content was also tracked, including information on in vitro model systems; exposure measurement–only studies in humans; and absorption, distribution, metabolism, and excretion (ADME). Animal bioassay and epidemiology studies meeting PECO criteria were summarized with respect to study design, and health system(s) were assessed. Because animal bioassay studies with exposure duration (or reproductive/developmental study design) were most useful to CCTE analyses, these studies underwent study evaluation and detailed data extraction. All data extraction is publicly available online as interactive visuals with downloadable metadata. Results: More than 40,000 studies were identified from scientific databases. Screening processes identified 44 animal and 148 epidemiology studies from the peer-reviewed literature and 95 animal and 50 epidemiology studies from gray literature that met PECO criteria. Epidemiological evidence (available for 15 PFAS) mostly assessed the reproductive, endocrine, developmental, metabolic, cardiovascular, and immune systems. Animal evidence (available for 40 PFAS) commonly assessed effects in the reproductive, developmental, urinary, immunological, and hepatic systems. Overall, 45 PFAS had evidence across animal and epidemiology data streams. Discussion: Many of the PFAS were data poor. Epidemiological and animal evidence were lacking for most of the PFAS included in our search. By disseminating this information, we hope to facilitate additional assessment work by providing the initial scoping literature survey and identifying key research needs. Future research on data-poor PFAS will help support a mo...

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Section: Resultsmentioning

confidence: 99%

Systematic Evidence Map for Over One Hundred and Fifty Per- and Polyfluoroalkyl Substances (PFAS)

Carlson

Angrish

Shirke

et al. 2022

Environ Health Perspect

View full text Add to dashboard Cite

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“…Feng et al [115] described the Nafion 117 membrane (N117), a polymer electrolyte membrane (PEM) utilized for different chemical technologies. They carried out studies on the histopathological alterations, oxidative stress biomarker responses, and transcriptome profiles in the liver of male mice exposed to N117 and its combustion products for 24 days.…”

Section: Bindersmentioning

confidence: 99%

The Toxicity of Secondary Lithium-Sulfur Batteries Components

Siczek

2020

Batteries

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Currently, apart from the widely known lithium-ion batteries, there are competitive solutions in the form of, for example, Li-S batteries. While the results of studies on the toxicity of Li-ion battery components are published, such studies on the components of Li-S cells are just beginning. The purpose of the current review was to identify materials used in the production of Li-S batteries and their toxicity, especially for humans. The review showed many kinds of materials with different levels of toxicity utilized for manufacturing of these cells. Some materials are of low toxicity, while some others are of the high one. A lot of materials have assigned different hazard statements. For some of the materials, no hazard statements were assigned, although such materials are toxic. No data related to the toxicity of some materials were found in the literature. This points out the need to further studies on their toxicity and legal actions to assign appropriate hazard statements.

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Transformation pathways of chlorinated paraffins relevant for remediation: a mini-review

Yuan

Wang

et al. 2021

Environ Sci Pollut Res

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Hepatic Transcriptome Responses in Mice (Mus musculus) Exposed to the Nafion Membrane and Its Combustion Products

Cited by 3 publications

References 54 publications

Systematic Evidence Map for Over One Hundred and Fifty Per- and Polyfluoroalkyl Substances (PFAS)

Systematic Evidence Map for Over One Hundred and Fifty Per- and Polyfluoroalkyl Substances (PFAS)

The Toxicity of Secondary Lithium-Sulfur Batteries Components

Transformation pathways of chlorinated paraffins relevant for remediation: a mini-review

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