Hepatic transport of the magnetic resonance imaging contrast agent gadobenate dimeglumine in the rat

Haën, Christoph de; Lorusso, Vito; Luzzani, Franco; Tirone, Piero

doi:10.1016/s1076-6332(05)80171-0

Cited by 32 publications

(13 citation statements)

References 18 publications

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“…As shown in the animal studies, over 90% of the injected dose of Gd-BOPTA and Gd-DTPA is cleared in the bile duct ligated rat. However, after the ligation of the renal vessel, only Gd-BOPTA can be eliminated via the bile [147].…”

Section: Hepatobiliary and Renal Agentsmentioning

confidence: 99%

Small molecular gadolinium(III) complexes as MRI contrast agents for diagnostic imaging

Chan

Wong

2007

Coordination Chemistry Reviews

170

118

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Section: Hepatobiliary and Renal Agentsmentioning

confidence: 99%

Small molecular gadolinium(III) complexes as MRI contrast agents for diagnostic imaging

Chan

Wong

2007

Coordination Chemistry Reviews

170

118

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“…The hepatic transport of Gd-BOPTA has been mainly studied in vivo using pharmacological antagonists. [7][8][9] A single study found that Gd-BOPTA crosses rat sinusoidal hepatocyte membrane by passive diffusion. 10 In the isolated perfused rat liver, however, evidence exists that Gd-BOPTA enters into hepatocytes through the same transporter as bilirubin and bromosulfophthalein, the organic anion transporting polypeptide 1 (Oatp1) localized on the sinusoidal membrane of hepatocytes.…”

mentioning

confidence: 99%

Gd-BOPTA Transport Into Rat Hepatocytes: Pharmacokinetic Analysis of Dynamic Magnetic Resonance Images Using a Hollow-Fiber Bioreactor

Planchamp

Gex‐Fabry²,

Dornier³

et al. 2004

Investigative Radiology

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Rationale and Objectives:To investigate the transport of the hepatobiliary magnetic resonance (MR) imaging contrast agent Gd-BOPTA into rat hepatocytes. Materials and Methods:In a MR-compatible hollow-fiber bioreactor containing hepatocytes, MR signal intensity was measured over time during the perfusion of Gd-BOPTA. For comparison, the perfusion of an extracellular contrast agent (Gd-DTPA) was also studied. A compartmental pharmacokinetic model was developed to describe dynamic signal intensity-time curves. Results: The dynamic signal intensity-time curves of the hepatocyte hollow-fiber bioreactor during Gd-BOPTA perfusion were adequately fitted by 2 compartmental models. Modeling permitted to discriminate between the behaviors of the extracellular contrast agent (Gd-DTPA) and the hepatobiliary contrast agent (Gd-BOPTA). It allowed the successfully quantification of the parameters involved in such differences. Gd-BOPTA uptake was saturable at high substrate concentrations. Conclusions: The transport of Gd-BOPTA into rat hepatocytes was successfully described by compartmental analysis of the signal intensity recorded over time and supported the hypothesis of a transporter-mediated uptake.

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“…Gd-BOPTA taken up selectively by hepatocytes is excreted into bile without biological processing. A total of 35-40% of injected Gd-BOPTA was shown to be excreted into bile in rats, whereas the ratio is only 3-5% in humans and the rest is excreted into urine through the kidneys (16,17). This property of Gd-BOPTA resembles the functional capability of Technetium-99m-hepatic iminodiacetic acid (HIDA), which is used for the diagnosis of various hepatobiliary disorders, including acute cholecystitis in nuclear medicine practice (18).…”

Section: Discussionmentioning

confidence: 99%

Initial experience on utility of gadobenate dimeglumine (Gd‐BOPTA) enhanced T1‐weighted MR cholangiography in diagnosis of acute cholecystitis

Akpınar

Türkbey

Karçaaltıncaba

et al. 2009

Magnetic Resonance Imaging

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PurposeTo investigate the feasibility of the use of gadobenate dimeglumine (also known as Gd‐BOPTA) ‐enhanced T1‐weighted MR cholangiography in diagnosis of acute cholecystitis.Materials and MethodsThis prospectively designed institutional review board‐approved HIPAA‐compliant study was done between January and November 2007. We included 11 consecutive patients (7 male, mean age 59 years) who presented to the emergency room with acute right upper quadrant pain and with equivocal physical examination and/or ultrasound findings. The control group included 15 patients who underwent liver MRI with Gd‐BOPTA. All patients underwent contrast‐enhanced (CE) MR cholangiography examinations. CE‐MR cholangiography was performed on a 1.5 Tesla magnet using 3D T1‐weighted high resolution isotrophic volume examination (THRIVE) obtained at the 90th min after intravenous injection of Gd‐BOPTA. Imaging features detected on CE‐MR cholangiography were correlated with operative and histopathologic findings.ResultsIn the control group, GD‐BOPTA was visualized within the gallbladder in all subjects. For the study group, gallstones were present in nine patients (n = 7 both in gallbladder and cystic duct, n = 1 only in gallbladder, n = 1 only in cystic duct) on MRCP. Hydropic gallbladder was detected in seven patients, significant wall thickening in seven patients, and pericholecystic free fluid in 6 patients. On delayed phase CE cholangiography, significant enhancement of gallbladder wall was seen in 10 patients, and contrast agent excretion into gallbladder was absent in all patients. Surgery was performed in 10 patients, and cholecystostomy was done in 1 patient. Surgery and histopathology findings were consistent with cholecystitis in all patients.ConclusionIn addition to anatomical assessment, Gd‐BOPTA‐enhanced MR cholangiography can provide functional evaluation similar to HIDA scintigraphy in diagnosing acute cholecystitis in patients with acute right upper quadrant pain and equivocal findings. J. Magn. Reson. Imaging 2009;30:578–585. © 2009 Wiley‐Liss, Inc.

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Hepatic transport of the magnetic resonance imaging contrast agent gadobenate dimeglumine in the rat

Cited by 32 publications

References 18 publications

Small molecular gadolinium(III) complexes as MRI contrast agents for diagnostic imaging

Small molecular gadolinium(III) complexes as MRI contrast agents for diagnostic imaging

Gd-BOPTA Transport Into Rat Hepatocytes: Pharmacokinetic Analysis of Dynamic Magnetic Resonance Images Using a Hollow-Fiber Bioreactor

Initial experience on utility of gadobenate dimeglumine (Gd‐BOPTA) enhanced T1‐weighted MR cholangiography in diagnosis of acute cholecystitis

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