Hepatic tumor ablation with clustered microwave antennae: the US Phase II Trial

Iannitti, David A.; Martin, Robert C.G.; Simon, Caroline J.; Hope, William W.; Newcomb, William L.; McMasters, Kelly M.; Dupuy, Damian E.

doi:10.1080/13651820701222677

Cited by 129 publications

(105 citation statements)

References 23 publications

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“…This may be due to increased experience of the doctors performing the treatment and more advanced MWA systems. This statement, however, is limited by the relatively small numbers of patients participating in the study of Iannitti et al 44 In SIRT, overall survival ranges between 8.3 and 12.6 months. Interestingly, the most recent study of Seidensticker et al, 25 reported the lowest overall survival with 8.3 months, whereas Cosimelli et al, 24 2 years earlier, recorded an overall survival of 12.6 months.…”

Section: Discussionmentioning

confidence: 99%

“…Repeated cycles of freezing are used to ensure necrosis of the tumour. 44 Although generally considered as safe, a unique complication that cryoablation can cause is cryoshock, in which the remnants of tumour cells are released into the system. This can cause a potentially life-threatening systemic inflammatory response with multiorgan failure.…”

Section: Microwave Ablationmentioning

confidence: 99%

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Current strategies in interventional oncology of colorectal liver metastases

Gruber‐Rouh

Marko

Thalhammer

et al. 2016

BJR

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The adequate treatment of non-resectable liver metastases from colorectal cancer which are resistant to systemic chemotherapy currently provides a great challenge. The aim is to identify and review key strategies in the treatment of colorectal liver metastases. A search for current literature on the topic of interventional strategies for colorectal metastases was performed in Medline in order to achieve this goal. Studies before 2005 and with ,20 patients treated for colorectal metastases were excluded. Transarterial chemoembolization (TACE), transarterial embolization and selective internal radiation therapy (SIRT) were identified as examples of regional strategies for colorectal liver metastases, utilizing the unique blood supply of the liver. Radiofrequency ablation (RFA), microwave ablation (MWA) and cryoablation were selected as examples for currently available ablative techniques. Median survival in the key studies reviewed ranged from 7.7 to 28.6 for TACE, 8.3-12.6 for SIRT, 8.2-53.2 for RFA and 29-43 months for MWA. After review of the literature, it can be concluded that interventional oncologic therapies are a safe and effective method for treating colorectal liver metastases. The use of new chemotherapeutic agents for local therapy and new ablation technologies and techniques may increase patient survival and allows a neoadjuvant therapy setting. In addition, a combination of local therapies may be used to increase effectiveness in the future, which is subject to further research. INTRODUCTIONColorectal cancer is one of the most common cancers that shows fatal progression.1 Colorectal carcinoma most commonly metastasises to the liver due to haematogenous spread.2 At the time of diagnosis, 20-30% of patients have liver metastases, and during the course of disease, up to 60% of patients develop hepatic metastases.3 Although surgical excision is the first-line treatment for colorectal metastases, only 10-25% of patients are candidates for surgical resection. 4 Neoadjuvant systemic chemotherapy only allows 10-30% of patients with unresectable colorectal liver metastases sufficient downsizing for resection.

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Section: Discussionmentioning

confidence: 99%

Section: Microwave Ablationmentioning

confidence: 99%

Current strategies in interventional oncology of colorectal liver metastases

Gruber‐Rouh

Marko

Thalhammer

et al. 2016

BJR

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“…92 Low power output and small-diameter ablation is one of the complications of MWA. 93 Water or gas antenna cooling has introduced a solution for making higher power microwave system. A retrospective cohort study reported that after utilizing a gas-cold system for MWA, overall primary technique effectiveness rate and OS rate were 91.6 and 76%, respectively.…”

Section: Microwave Ablation (Mwa)mentioning

confidence: 99%

New modalities of treatment for hepatocellular carcinoma

Behnagh

Rezaei

Jahannia

et al. 2017

J. contemp. med. sci.

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Hepatocellular carcinoma (HCC) is the second most common cause of death from cancer worldwide. Managing HCC is difficult. However, there are many treatment options available such as liver transplantation, radiotherapy, different ablative techniques, surgery, trans-arterial chemoembolization (TACE) and systemic therapy. These treatments did not show the promising responses and the recurrence rate is still high. On the other hand, there are some new treatments such as immunotherapy, gene therapy, combination of different therapies, Chinese traditional therapies and new targeted therapies. The aim of this study is to review both the recent changes in the common therapies and newly developed therapies of HCC.

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“…The world experience with this new generation system is particularly small. An author of this review (Iannitti, DA) has published the largest reported United States experience with MWA of liver tumors [24,[159][160][161][162]. In the Phase I trial [159], under an ''Ablate and Resect'' protocol, eleven patients were treated with a single application of three-clustered microwave antennae for 10 min at 45 W per antenna.…”

Section: Microwave Ablation (Mwa) For Hccmentioning

confidence: 99%

“…This produced an average tumor ablation volume of 50.4 cu cm. In the Phase II study [162] of an ''Ablate and Leave'' protocol, 87 patients were enrolled. Their liver tumors consisted of 33 colorectal metastases and 23 HCCs.…”

Section: Microwave Ablation (Mwa) For Hccmentioning

confidence: 99%

Liver tumor ablation: Percutaneous and open approaches

Padma

Martinie

Iannitti

2009

Journal of Surgical Oncology

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The global incidence of liver cancer is greater than a million cases a year. Surgical resection where applicable is still the standard of care for these patients. Various liver-directed regional therapies have been developed in an effort to treat the vast majority of unresectable liver tumors. This article reviews the principles behind various ablation therapies currently available for malignant liver tumors and their outcomes.

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Hepatic tumor ablation with clustered microwave antennae: the US Phase II Trial

Abstract: Microwave ablation is a safe and effective technology for hepatic tumor ablation. In our study, clustered antennae resulted in larger ablation volumes. Further studies with histological confirmation are needed to verify clinical results.

Cited by 129 publications

References 23 publications

Current strategies in interventional oncology of colorectal liver metastases

Current strategies in interventional oncology of colorectal liver metastases

New modalities of treatment for hepatocellular carcinoma

Liver tumor ablation: Percutaneous and open approaches

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