Hepatic vein occlusion disease of Egyptian children

Egyptian Hepatic Veno-Occlusive Disease: Surgical Point of View

“…Safouh et al; 1965 [11] reported the following results: # Most of the cases showed some degree of anemia.…”

“…Since 1939 several reports pointed out the occurrence of a specific syndrome among Egyptian children who rapidly developed abdominal distention with ascites and hepatomegaly. In 1965, Safouh et al [11]; reported that 54 Egyptian children were studied and the term "Hepatic vein occlusion disease in Egyptian children" was applied. At the same year, El Gholmy 1956 [10], studied a group of patients and introduced the term "Infantile cirrhosis of Egypt"…”

“…They also have shown clearly for the first time that hepatic vein occlusion should be considered in the diagnosis of Egyptian children presenting with hepatosplenomegaly [11]. Safouh 1965 [11], reported that the Egyptian hepatic vein occlusion is the result of enhanced thrombotic activity of the blood with the formation of fibrinous thrombi followed by organization and thickening or closure of the vessels, a finding which seems peculiar to the Egyptian cases and thus differs from the classical HVOD.…”

Splanchnic Vein Thrombosis in the Mediterranean Area in Children

“…Four local reports from Egypt referred to children who rapidly develop abdominal distention with ascites and hepatomegaly. Dilated veins soon become apparent in their anterior abdominal walls, the spleen does not enlarge at the onset, and jaundice is either absent or slight 29,30,31,32…”

“…Professor Mohammad Safouh, the father of Pediatric Hepatology in Egypt, published his first international report on VOD in 1965 33. These cases were frequently seen at that time.…”