Hepatite infecciosa canina: relato de caso Infectious canine hepatitis: case report

Piacesi, Tathiana Mourão Anjos; César, Julio; Veado, Cambraia; Bandeira, Cecília Muller; Carneiro, Rubens Antônio; António, Fernando; Viana, Bretas; Costa, Adriane Pimenta da; Bicalho, Val

doi:10.4322/rbcv.2014.155

Cited by 2 publications

(2 citation statements)

References 25 publications

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“…The clinical symptomatology described here agreed with those described by earlier workers (Zee and Maclachlan, 2004;Decaro et al, 2008;Piacesi et al, 2010). Similar signs have also been described by earlier workers (Mosallanejad et al, 2010) in a 3-month-old male German shepherd dog.…”

Section: Macroscopical Findings At Necropsysupporting

confidence: 92%

“…ICH is transmitted via ingestion of faeces, urine, blood, saliva and nasal discharge of infected dogs (W illis, 2000). Again, animals that survive the infection reportedly carry and shed the virus through nasal discharge and urine, for at least 6 to 9 months and 11 months, respectively (Piacesi et al, 2010). After being contracted naso-orally, the virus initially replicates in the tonsillar crypts and Peyer patches, followed by viremia and disseminated infection.…”

Section: Resultsmentioning

confidence: 99%

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Fatal Canine Adenovirus Type 1 Infection in Dhole (Cuon alpinus) Pups

Manjunatha,

Rout,

Srinivas

et al. 2024

IJAR

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Background: Infectious canine hepatitis (ICH) is an uncommonly recognized disease of dogs and wild canids. This study aimed to investigate and report an outbreak of infectious canine hepatitis (ICH) caused by canine adenovirus type 1 (CAV-1) in dhole (Cuon alpinus) pups at Bannerghatta Biological Park, Bengaluru, Karnataka. Methods: During this investigation, four dhole pups succumbed following a short clinical course of ICH. Clinical biochemical and hematological tests were done. Gross and histopathological observations were made along with genome detection through PCR. Result: Clinical findings comprised of leucopenia, thrombocytopenia and anaemia with high levels of total and direct bilirubin as well as ALT, AST and ALP enzymes. The necropsy findings were sub-mandibular edema, generalised icterus, petechial haemorrhages on liver, spleen, lungs, kidneys and skeletal muscles. Liver was enlarged, haemorrhagic, friable and severely icteric with rounded borders. Histopathologically, intranuclear inclusion bodies typical of CAV-1 infection could be observed in hepatocytes and Kupffer cells in the liver. The disease confirmation was done on histopathological findings and detection of CAV-1 genome through PCR.

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Section: Macroscopical Findings At Necropsysupporting

confidence: 92%

Section: Resultsmentioning

confidence: 99%

Fatal Canine Adenovirus Type 1 Infection in Dhole (Cuon alpinus) Pups

Manjunatha,

Rout,

Srinivas

et al. 2024

IJAR

View full text Add to dashboard Cite

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Fatal canine adenovirus type 1 acute infection in a Yorkshire Terrier puppy in Portugal: a case report

Duarte¹,

Henriques²,

Lima³

et al. 2014

Vet. Med. - Czech

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This study reports the diagnostic algorithm followed for the identification of a fatal canine adenovirus type 1 (CAdV-1) infection in an unvaccinated 56 day-old puppy to overcome the limitations imposed by inconclusive histopathology hampered by body freezing. The animal was submitted to necropsy after a clinical history of lethargy, dehydration, vomiting and haemorrhagic diarrhoea. Pathological features, suggestive of infectious illness, included generalised gelatinous subcutaneous oedema, petechial, ecchymotic haemorrhages of the subcutaneous tissues and a friable uniformly yellow mottled liver. Differential diagnosis based on PCR ruled out the presence of most common gastrointestinal canine viruses and bacteriology and coprology confirmed that pathogenic bacteria and intestinal parasites did not account for the puppy's death. Strong amplification of CAdV-1 DNA was obtained from liver samples. Isolation of CAdV-1 in MDCK cells was subsequently demonstrated and sequencing analysis showed high similarity with CAdV-1 isolates from Europe. In the absence of serum, antibodies against CAdV-1 were investigated in lung tissue extracts. The presence of CAdV-1 infectious particles and absence of immune response was consistent with rapid progression of the infection and death of the animal two days after the onset of clinical signals, allowing a final diagnosis of the acute form of ICH. Antibodies against CAdV-1 were detected in sera collected from clinically healthy dogs from the same premises, 14-months after the index case, suggesting that the virus had circulated in the breeding kennel. We believe this to be the first report of CAdV-1 in Portugal where canine infectious hepatitis is considered a rare infection.Keywords: canine adenovirus type 1; CAdV-1; infectious canine hepatitis; Mastadenovirus List of abbreviations BID = twice a day, CAdV-1 = canine adenovirus type 1; CAdV-2 = canine adenovírus type 2, CCoV = canine coronavirus; CDV = canine distemper virus, CHV = canine herpesvirus, CPIV = canine parainfluenza virus, CPV = canine parvovirus, CPE = cytopathic effect, ELISA = enzyme linked immunosorbent assay, FCS = foetal calf serum, FITC = fluoresceine isothiocyanate, ICH = infectious canine hepatitis, IgG = immunoglobulin G, IIF = indirect immunofluorescence, LTE = lung tissue extract, MDCK = Madin-Darby canine kidney, PBS = phosphate-buffered saline, PCR = polymerase chain reaction, RV = rotavirus, SID = once a day

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Hepatite infecciosa canina: relato de caso Infectious canine hepatitis: case report

Cited by 2 publications

References 25 publications

Fatal Canine Adenovirus Type 1 Infection in Dhole (Cuon alpinus) Pups

Fatal Canine Adenovirus Type 1 Infection in Dhole (Cuon alpinus) Pups

Fatal canine adenovirus type 1 acute infection in a Yorkshire Terrier puppy in Portugal: a case report

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