Hépatite virale B: aspects cliniques, paracliniques et évolutifs dans le service d’Hépato Gastroentérologie de l’Hôpital Aristide Le Dantec: à propos de 728 cas

Diallo, Salamata; Bassène, Marie Louise; Guèye, Mamadou Ngoné; Thioubou, Mame Aïssé; Dia, D.; Mbengue, M.; Diouf, M. L.

doi:10.11604/pamj.2018.31.82.14725

Cited by 10 publications

(15 citation statements)

References 10 publications

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“…According to the clinical signs, liver ultrasound and Fibrotest* we found 19.4% cirrhosis at diagnosis. This result is similar to the one reported by Diallo S. et al in Senegal (22.11%) [16] but lower than the one found by Lawson et al…”

Section: Discussionsupporting

confidence: 90%

Epidemiological, Clinical and Biological Characteristics of Patients with Chronic Hepatitis B Infection Followed-Up at the University Hospital of Conakry, Guinea

Djenabou¹,

Diallo²,

Diallo³

et al. 2020

OJGas

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Introduction: Very little information is available in Guinea on chronic hepatitis B infections. The objective of this study was to describe the epidemiological, clinical and biological features of patients who are chronic carriers of the hepatitis B virus. Patients and Methods: This is a retrospective study carried out from January 2017 to May 2020, based on the medical records of patients seen via consultation or hospitalized with a record of positive HBs antigen for more than 6 months. Clinical and paraclinical data were collected and analyzed. Results: Seven hundred and sixteen patients with a mean age of 35.6 ± 12.2 (sex ratio 2.05), were included. The HBs antigen was discovered incidentally in 36% of cases (n = 258). A history of dental care and surgical procedures was found in 46.3% (n = 290) and 21.1% (n = 138) of cases, respectively. The median value of ALAT enzymes was 34 (21 -47) IU/L. HBeAg was positive in 20.8% (n = 55/265) of cases. The median B viral load was 458.5 (87 -3827) IU/ml and 29% (n = 94) of patients had a viral load over 2000 IU/ml. Anti-HCV antibody was present in 10.4 % of cases (n = 39/374). HIV serology was positive in 2.7% (n = 8/298). A total of 19.4% (n = 139) of the patients had cirrhosis and 4.5% (n = 32) had hepatocellular carcinoma. Conclusion: The discovery of chronic HBs antigen was mostly fortuitous in young sexually active men, some of whom were already at the stage of cirrhosis and hepatocellular carcinoma. The best prevention strategy against this infection remains early detection and vaccination.

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Section: Discussionsupporting

confidence: 90%

Epidemiological, Clinical and Biological Characteristics of Patients with Chronic Hepatitis B Infection Followed-Up at the University Hospital of Conakry, Guinea

Djenabou¹,

Diallo²,

Diallo³

et al. 2020

OJGas

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“…This same observation was made by Agbenu et al Open Journal of Gastroenterology in Togo [11]. Diallo et al in Senegal found a sex ratio of 2.2 [9].…”

Section: Discussionsupporting

confidence: 82%

“…Amidu et al in Ghana found an age of 37.93 ± 0.93 years [8]. On the other hand Diallo et al in Senegal found a mean age of 33 years [9].…”

Section: Discussionmentioning

confidence: 99%

Frequency of Viral Replication Markers in Chronic HBV Carriers in N’Djamena, Chad

Moussa¹,

Habkreo²,

Adawaye³

et al. 2022

OJGas

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Introduction: According to the WHO, Chad is located in an area of high endemicity for hepatitis B virus (HBV). The aim of this study was to analyze the virological profiles of chronic HBV carriers. Materials and Method: This was a retrospective and analytical study including outpatients with chronic HBV of any age received in Department of Internal Medicine and Gastroenterology of National General Reference Hospital of N'Djamena from 2013 to 2017. Results: During the study period, 401 chronic hepatitis B virus carriers (mean age was 35 years ± 11 years with sex ratio of 3.26) were seen in outpatient clinic with a frequency of 3.34% (401/11,988). HBeAg (+) patients were 12.8% and HBeAg negative 87.2%. HBeAg-negative patients were significantly older (p = 0.000) than those with HBeAg (+). The mean HBV-DNA level was higher in HBeAg (+) patients. The HBV-DNA level in HBeAg-positive patients was higher than in HBeAg-negative patients with a significant difference (p = 0.043). The mean ALT level was 45 IU/L in HBeAg (−) patients. It was 49 in HBeAg (+) patients. Conclusion: HBeAg (−) chronic hepatitis B is the most predominant form in our study. This observation is important because it can help to adapt the management strategies.

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“…However, in the one hand, the unfavorable socioeconomic level is more impacted by CHB [ 85 ]. On the other hand, the socioeconomic profile of our NC-CHB patients is representative of African patients with CHB [ 86 ]. According to a Senegalese study [ 86 ], due to socio-economic difficulties, the serological status was undetermined in 34.6% of patients.…”

Section: Methodology Discussion and Study Limitationsmentioning

confidence: 99%

“…On the other hand, the socioeconomic profile of our NC-CHB patients is representative of African patients with CHB [ 86 ]. According to a Senegalese study [ 86 ], due to socio-economic difficulties, the serological status was undetermined in 34.6% of patients. The third limitation is related to the non-practice of the HBV-DNA test and a fibroscan in the control group to confirm the absence of HBV and hepatic fibrosis, respectively.…”

Section: Methodology Discussion and Study Limitationsmentioning

confidence: 99%

Evaluation of muscle strength and quality in North African patients with chronic hepatitis B: A pilot case control study

Bergaoui

Latiri

Chaouch

et al. 2023

Libyan Journal of Medicine

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Early detection of alteration of muscle strength, quantity, and quality, and sarcopenia is useful in non-cirrhotic chronic hepatitis B (NC-CHB) patients. Studies, which explored the handgrip strength (HGS) are scarce with questionable results, and no previous case-control study explored the presence of sarcopenia. The aim of this study was to assess the muscle strength [i.e.; HGS absolute (HGS A ), HGS A /body mass index (BMI)], muscle quantity [i.e.; appendicular skeletal muscle (ASM), ASM/height 2 , ASM/total body weight (TBW), ASM/BMI], and muscle quality [i.e.; HGS A /total muscle mass (TMM), HGS A /ASM] of NC-CHB patients. This was a case-control study. Cases ( n = 26) were untreated NC-CHB patients, and controls ( n = 28) were ‘apparently’ healthy participants. Muscle mass was estimated via the TMM (kg) and ASM (kg). Muscle strength was evaluated via the HGS data [i.e.; HGS A (kg), HGS A /BMI (m 2 )]. Six variants of HGS A were determined: highest values for the dominant and non-dominant hands, highest value between the two hands, averages of the three measurements for the two hands, and the average of the highest values of the two hands. Muscle quantity was expressed in three relative variants (ASM/height 2 , ASM/TBW, and ASM/BMI). Muscle quality was evaluated via relative HGS data adjusted by muscle mass (i.e.; HGS A /TMM, HGS A /ASM). Probable and confirmed sarcopenia were retained in front of low muscle strength, and low muscle strength and muscle quantity or quality, respectively. There were no significant differences between controls and NC-CHB patients in values of muscle i) Strength whatever the HGS’ mode of expression (e.g.; HGS A /BMI: 1.59 ± 0.54 vs. 1.53 ± 0.54 m 2 , p = 0.622, respectively), ii) Quantity (e.g.; ASM/BMI: 0.79 ± 0.24 vs. 0.77 ± 0.23 m 2 , p = 0.883), and iii) Quality (e.g.; HGS A /ASM: 2.00 ± 0.25 vs. 2.01 ± 0.41, p = 0.952, respectively). One NC-CHB participant had a confirmed sarcopenia. To conclude, both controls and NC-CHB patients had similar HGS values. Only one NC-CHB patient had a confirmed sarcopenia.

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Hépatite virale B: aspects cliniques, paracliniques et évolutifs dans le service d’Hépato Gastroentérologie de l’Hôpital Aristide Le Dantec: à propos de 728 cas

Cited by 10 publications

References 10 publications

Epidemiological, Clinical and Biological Characteristics of Patients with Chronic Hepatitis B Infection Followed-Up at the University Hospital of Conakry, Guinea

Epidemiological, Clinical and Biological Characteristics of Patients with Chronic Hepatitis B Infection Followed-Up at the University Hospital of Conakry, Guinea

Frequency of Viral Replication Markers in Chronic HBV Carriers in N’Djamena, Chad

Evaluation of muscle strength and quality in North African patients with chronic hepatitis B: A pilot case control study

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