Hépatites virales chroniques chez les patients insuffisants rénaux

Chaabane, N. Ben; Loghmari, Hichem; Melki, W.; Hellara, O.; Safer, L.; Bdioui, F.; Saffar, Hiva

doi:10.1016/j.lpm.2007.10.013

Cited by 4 publications

(2 citation statements)

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“…In the present study, the risk estimates of death due to intracerebral haemorrhage did not change materially after adjusting for the presence of chronic hepatitis or cirrhosis at baseline, suggesting that advanced liver damage might not be the causal intermediate between HBV infection and intracerebral haemorrhage. HBV-induced proinflammatory effect25 and steatosis,26 further leading to endothelial dysfunction and acceleration of atherosclerosis, may play an essential role in the development of cardiovascular diseases. The individual pathophysiological mechanisms that link the HBV infection and different cardiovascular endpoints still warrant further elucidation.…”

Section: Discussionmentioning

confidence: 99%

Chronic hepatitis B virus infection and total and cause-specific mortality: a prospective cohort study of 0.5 million people

Guo

et al. 2019

BMJ Open

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ObjectivesChronic hepatitis B virus (HBV) infection is associated with a higher risk of liver diseases. Substantial uncertainty remains, however, about the associations of HBV infection with mortality from extrahepatic causes, especially from subtypes of cardiovascular diseases. We prospectively examined the association of chronic HBV infection with total and cause-specific mortality.DesignPopulation-based prospective cohort study.SettingChina Kadoorie Biobank in which participants from 10 geographically diverse areas across China were enrolled between 2004 and 2008.Participants475 801 participants 30–79 years of age without reporting major chronic diseases at baseline were enrolled. Hepatitis B surface antigen (HBsAg) was tested using an on-site rapid test strip at baseline.Primary and secondary outcome measuresTotal and cause-specific mortality.ResultsA total of 35 822 deaths were recorded during ~10 years of follow-up. In multivariable-adjusted analyses, compared with HBsAg-negative participants, HBsAg-positive participants had an increased risk of total mortality (HR=2.01, 95% CI: 1.91 to 2.12), which was higher in men (HR=2.16, 95% CI: 2.01 to 2.31) than in women (HR=1.74, 95% CI: 1.60 to 1.90). Presence of HBsAg was associated with increased mortality from liver cancer (1339 deaths, HR=13.95, 95% CI: 12.46 to 15.62), infections (410 deaths, HR=10.30, 95% CI: 8.21 to 12.94), digestive diseases (688 deaths, HR=6.83, 95% CI: 5.49 to 8.50), intracerebral haemorrhage (4077 deaths, HR=1.38, 95% CI: 1.14 to 1.68) and ischaemic heart diseases (4624 deaths, HR=1.31, 95% CI: 1.09 to 1.58). The positive association between HBsAg status and risk of death was stronger in participants younger than 50 years, smokers, physically active or non-hypertensive participants.ConclusionsAmong Chinese adults, chronic HBV infection was associated with increased mortality from a range of hepatic and extrahepatic diseases.

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Section: Discussionmentioning

confidence: 99%

Chronic hepatitis B virus infection and total and cause-specific mortality: a prospective cohort study of 0.5 million people

Guo

et al. 2019

BMJ Open

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“…The pathogenesis of HBV-associated nephropathy remains unclear, and several mechanisms have been implicated. Steatosis, a typical feature of chronic HBV infection, could induce lipid peroxidation and increase plasma inflammatory biomarkers, leading to endothelial dysfunction and renal injury [ 18 ]. It is also suggested that HBV carriers are more likely to have increased insulin resistance and a higher circulating level of transforming growth factor ß, contributing to the potentiation of apoptosis and renal fibrosis [ 19 , 20 ].…”

Section: Discussionmentioning

confidence: 99%

Chronic hepatitis B virus infection and risk of chronic kidney disease: a population-based prospective cohort study of 0.5 million Chinese adults

Guo

et al. 2018

BMC Med

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BackgroundExisting evidence remains inconclusive as to the association between chronic hepatitis B virus (HBV) infection and the risk of chronic kidney disease (CKD). We prospectively examined the association between chronic HBV infection and CKD risk, and the joint associations of HBV infection with established risk factors of several lifestyle factors and prevalent diseases on CKD risk.MethodsParticipants from the China Kadoorie Biobank were enrolled during 2004–2008 and followed up until 31 December 2015. After excluding participants with previously diagnosed CKD, cancer, heart disease, and stroke at baseline, the present study included 469,459 participants. Hepatitis B surface antigen (HBsAg) was qualitatively tested at baseline. Incident CKD cases were identified mainly through the health insurance system and disease and death registries.ResultsDuring a median follow-up of 9.1 years (4.2 million person-years), we documented 4555 incident cases of CKD. Cox regression yielded multivariable-adjusted hazard ratios (HRs) and 95% confidence intervals (CIs). Compared with HBsAg-negative participants, the multivariable-adjusted HR (95% CI) for CKD was 1.37 (1.18, 1.60) for HBsAg-positive participants. The association was stronger in men (HR = 1.77; 95% CI: 1.43, 2.20) than in women (HR = 1.10; 95% CI: 0.88, 1.36). HBsAg-positive participants, with or without hepatitis or cirrhosis, whether or not under treatment, all showed increased risk of developing CKD. We observed positive additive interactions of HBsAg positivity with smoking, physical inactivity, or diabetes on CKD risk. Compared with HBsAg-negative participants who were nonsmokers, more physically active, or did not have diabetes at baseline, the greatest CKD risk for HBsAg-positive participants was for those who were smokers (HR = 1.85; 95% CI: 1.44, 2.38), physically inactive (HR = 1.91; 95% CI: 1.52, 2.40), or diabetic (HR = 6.11; 95% CI: 4.47, 8.36).ConclusionsIn countries with a high endemicity of HBV infection, kidney damage associated with chronic HBV infection should be a non-negligible concern. Our findings also highlight the importance of health advice on quitting smoking, increasing physical activity, improving glucose control, and early screening for CKD in people with chronic HBV infection.Electronic supplementary materialThe online version of this article (10.1186/s12916-018-1084-9) contains supplementary material, which is available to authorized users.

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Mendelian randomization of chronic hepatitis B and cardiovascular disease

Wu,

Xiong,

Ran

et al. 2024

Front. Cardiovasc. Med.

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BackgroundEvidence from observational studies suggests that chronic hepatitis B (CHB) is associated with cardiovascular disease (CVD). However, results have been inconsistent and causality remains to be established. We utilized two-sample Mendelian randomization (MR) to investigate potential causal associations between CHB and CVD, including atherosclerosis, coronary heart disease, hypertension, and ischemic stroke.MethodsThe analysis was conducted through genome-wide association studies (GWAS), considering chronic hepatitis B as the exposure and cardiovascular disease as the endpoint. The primary method for evaluating causality in this analysis was the inverse-variance weighted (IVW) technique. Additionally, we employed the weighted median, MR-Egger regression, weighted mode, and simple mode methods for supplementary analyses. Finally, heterogeneity tests, sensitivity analyses, and multiple effects analyses were conducted.ResultsIn a random-effects IVW analysis, we found that genetic susceptibility to chronic hepatitis B was associated with an increased risk of atherosclerosis [OR = 1.048, 95% CI (1.022–1.075), P = 3.08E-04], as well as an increased risk of coronary heart disease [OR = 1.039, 95% CI (1.006–1.072), P = 0.020]. However, it was found to be inversely correlated with ischemic stroke risk [OR = 0.972, 95% CI (0.957–0.988), P = 4.13E-04]. There was no evidence that chronic hepatitis B was associated with hypertension [OR = 1.021, 95% CI (0.994–1.049), P = 0.121].ConclusionOur research indicates that chronic hepatitis B has a correlation with an elevated risk of developing atherosclerosis and coronary heart disease, while it is associated with a decreased risk of experiencing an ischemic stroke.

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Hépatites virales chroniques chez les patients insuffisants rénaux

Cited by 4 publications

References 151 publications

Chronic hepatitis B virus infection and total and cause-specific mortality: a prospective cohort study of 0.5 million people

Chronic hepatitis B virus infection and total and cause-specific mortality: a prospective cohort study of 0.5 million people

Chronic hepatitis B virus infection and risk of chronic kidney disease: a population-based prospective cohort study of 0.5 million Chinese adults

Mendelian randomization of chronic hepatitis B and cardiovascular disease

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