Hepatitis A in young adults in the golestan province, northeast of Iran

Moradi, Abdolvahab; Khodabakhshi, Behnaz; Besharat, Sima; Teimoorian, Mehrdad

doi:10.4103/0974-777x.62862

Cited by 8 publications

(4 citation statements)

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“…Several studies in Iran have assessed the risk factors for HAV infection; our results are in agreement with the study in the Golestan province, in which the number of family members, level of education of the person, and level of education in parents were not statistically different between the HAV positive and negative adolescents (13). The same results are reported from Kashan, Qum, and Isfahan, with no detectable association between HAV infection and family size (17-19).…”

Section: Discussionsupporting

confidence: 91%

“…HAV seroprevalence was 86.76% in 17-year-old adolescents in the Golestan province (13), 61.6% in individuals under 20 who were referred to a hospital in Tehran (14), 79.3% in 15 to 20-year-old persons referred for pre-marriage consultations in the Fars province (9), 64.7% in 15 to 24-year-old adolescents in Mashhad in the Razavi Khorasan province (15), and 79.4% in 16 to 29-year-olds in Shiraz, the provincial city of the Fars province (8). In contrast, HAV seroprevalence was 38.9% in under 25-year-olds in Sari (center of Mazanderan province) (16), 10% in 6-20-year-olds in a population- based study in Isfahan province (17), and 3.9% in children under 15 in Kashan (in the Isfahan province) (18), which are much lower than in other reports.…”

Section: Discussionmentioning

confidence: 99%

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Comparison of the Prevalence and Risk Factors of Hepatitis A in 10 to 18-Year-Old Adolescents of Sixteen Iranian Provinces: The CASPIAN-III Study

et al. 2016

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BackgroundHepatitis A is a common health concern both in developing and developed countries. Hygienic and socioeconomic parameters deeply impact the prevalence and transmission of this disease. Evaluating the epidemiological distribution and risk factors for Hepatitis A virus (HAV) is necessary for policy makers to improve local and national preventive measures.ObjectivesThe aim of this study was to compare the prevalence of hepatitis A infection in a sample of Iranian adolescents living in different provinces of Iran and to assess its family- and community-related risk factors.MethodsIn this cross-sectional study, serum samples of 10 to 18-year-old adolescents, who were studied in a national health survey, were examined for anti-HAV antibodies. A total of 2,494 subjects were included from 16 provinces by multistage random cluster sampling. Demographic and socioeconomic factors related to HAV transmission were extracted by valid questionnaires. A multilevel analysis using mixed-effects logistic regression (melogit) was used to evaluate the association of risk factors with HAV infection.ResultsThe weighted prevalence of HAV varied significantly across the studied provinces (P = 0.001), ranging from 50.43% in the Fars province to 78.81% in Markazi province. HAV was significantly more prevalent in children whose mothers worked outside of the home (OR, 1.73; 95% CI, 1.14-2.62; P = 0.009).ConclusionsThe risk of symptomatic HAV infection is considerable in adolescents of all studied provinces; thus, universal HAV vaccination is recommended for all adolescents, regardless of their socioeconomic level. However, the risk is higher in some provinces, which seem to be transitioning from intermediate to low endemicity.

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Section: Discussionsupporting

confidence: 91%

Section: Discussionmentioning

confidence: 99%

Comparison of the Prevalence and Risk Factors of Hepatitis A in 10 to 18-Year-Old Adolescents of Sixteen Iranian Provinces: The CASPIAN-III Study

et al. 2016

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“…One possible explanation is the small sample size of the present study. It is similar to the current findings reported from Fars (43), Hormozgan (34), and Golestan (32) provinces and a report from Babol (33) that showed the seroprevalence rates of HAV were not statistically different between urban and rural residents. The present study examined the seropositivity of HAV in educational and employment status, and in line with results of previous studies, uneducated and unemployed parents had HAV seropositive children (15).…”

Section: Discussionsupporting

confidence: 91%

“…In line with the results of some previous studies that male subjects were observed to have a significantly higher seroprevalence than female subjects, the current study also observed a significantly higher seropositivity rate in male participants. Regarding gender, various studies have shown different results, reporting no significant difference (17,(32)(33)(34) or some female cases (24,27,35) and some male cases more prone to HAV (19,24). The inconsistent findings of the aforementioned studies might be due to the differences in methods and selected populations.…”

Section: Discussionmentioning

confidence: 99%

Status of Immunity Against the Hepatitis A Virus in Healthy Population: A Report from Southeastern Iran

Bakhshipour

Sargolzaie

Rafaiee

2021

Arch Clin Infect Dis

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Background: Recently, epidemiological studies on hepatitis A virus (HAV) infection showed the seroprevalence has been changing due to changes in lifestyle. To the best of our knowledge, there have been no published data on the seropositivity of HAV in Zahedan, southeastern Iran. Objectives: This study aimed to investigate the seroprevalence of HAV immunoglobulin G (IgG) antibody in Zahedan, southeastern Iran, to provide the required information for better planning in preventive strategies. Methods: In this cross-sectional study, using the available sampling method, a total of 250 serum samples (18 years and above) in both the urban and rural areas of Zahedan were evaluated for anti-HAV IgG by enzyme-linked immunosorbent assay. Results: Based on the results, it was observed that 228 out of 250 (91.2%) serum samples were positive for HAV IgG antibody. Male gender, family size, parents’ education, mother’s occupation, and history of jaundice before the age of 12 years were associated with positive HAV antibody (P < 0.001). The seroprevalence HAV rates were not statistically different between the residents of urban and rural regions. Conclusions: The seropositivity of HAV is high in both the urban and rural areas of Zahedan, Iran. Therefore, the HAV vaccination of the general population is not necessary. It is recommended to monitor HAV seroprevalence in the general population to determine high-risk groups, including anti-HAV seronegative individuals, for HAV vaccination in the residents of the southeast border.

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Determinants of poor outcome in patients with hepatitis A infection: a four-year retrospective study in Shiraz, Southern Iran

et al. 2014

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There are 1.4 million estimated cases of hepatitis A every year worldwide. We aimed to detect the correlates of poor outcome in patients with hepatitis A virus (HAV) infection. In this four-year retrospective study, which was conducted in Shiraz, Southern Iran, data of all hospitalized HAV patients were analyzed by SPSS and STATA. Out of 110 HAV patients, 8 (7.3 %) developed hepatic encephalopathy, and 7 (6.4 %) died. The results show that 19 years of age is a cutoff level for predicting mortality, with a sensitivity of 42.9 % and specificity of 91.3 %, and with an area under the curve (AUC) of 0.595 (95 % CI, 0.309-0.881). Every one-year increase in age adds 3 % to the mortality rate from severe hepatitis A. The cutoff level of alanine aminotransferase (ALT) for predicting death is 1819.5 IU/L, with a sensitivity of 100 %, specificity of 68 %, and AUC 0.877 (95 % CI, 0.777-0.977). Every 100 IU/L increase in ALT is associated with a 0.1 % increase in the risk of death. Patients from large families (OR, 0.583, 95 % CI, 0.46-0.74) and those who are not the firstborn child of their family (OR, 0.287, 95 % CI, 0.146-0.564) have better outcome. Adult patients with hepatitis A who are first children, are from a small family, or have a very high level of ALT are more prone to a poor outcome of this infection. Public education and establishment of a national surveillance system for HAV and an HAV vaccination program for high-risk populations should be regarded among the priorities of the health system of Iran.

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Hepatitis A in young adults in the golestan province, northeast of Iran

Cited by 8 publications

References 5 publications

Comparison of the Prevalence and Risk Factors of Hepatitis A in 10 to 18-Year-Old Adolescents of Sixteen Iranian Provinces: The CASPIAN-III Study

Comparison of the Prevalence and Risk Factors of Hepatitis A in 10 to 18-Year-Old Adolescents of Sixteen Iranian Provinces: The CASPIAN-III Study

Status of Immunity Against the Hepatitis A Virus in Healthy Population: A Report from Southeastern Iran

Determinants of poor outcome in patients with hepatitis A infection: a four-year retrospective study in Shiraz, Southern Iran

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