Hepatitis A-Induced Diabetes Mellitus, Acute Renal Failure, and Liver Failure

Vesely, David L.; Dilley, Roger W.; Duckworth, William C.; Paustian, Frederick F.

doi:10.1016/s0002-9629(15)40557-9

Cited by 8 publications

(4 citation statements)

References 15 publications

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“…The rapidly resolved renal condition made the kidney biopsy unjusti iable. This fruitful outcome connected to improved bilirubin levels was similar to what's mentioned in literature except for the temporary need of hemodialysis in some cases [20,21]. Nevertheless, improved renal disorders associating HAV infections following corticosteroids treatment had been reported [29].…”

Section: Discussionsupporting

confidence: 79%

“…Fulminant hepatitis had been reported to complicate less than 1% of HAV infections [18]. The linkage between renal failure and HAV infection was limited to fulminant cases except in very few reports [19][20][21]. Meanwhile, in HAV infections that are exhibiting benign course, renal disorders are rare to occur and only few reports had mentioned this particular complication in mild HAV infections [22,23,9].…”

Section: Discussionmentioning

confidence: 99%

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Complicated Hepatitis A Virus Infection: A Report of Three Cases from Single Tertiary Referral Center

Alhaddad¹,

Elsabaawy²,

Gameel³

et al. 2016

J Clin Intensive Care Med

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Section: Discussionsupporting

confidence: 79%

Section: Discussionmentioning

confidence: 99%

Complicated Hepatitis A Virus Infection: A Report of Three Cases from Single Tertiary Referral Center

Alhaddad¹,

Elsabaawy²,

Gameel³

et al. 2016

J Clin Intensive Care Med

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show abstract

“…[8][9][10][11][12][13][14][15][16][17][18] However, recent studies in Korea have suggested that AKI is not a rare complication having incidence rate from 3% up to 7.2%. [2][3][4][5] In this study, the rates of AKI were 7.6% in whole hepatitis A cases, and 5.8% in nonfulminant cases.…”

Section: Discussionmentioning

confidence: 99%

Clinical features and outcomes of acute kidney injury among patients with acute hepatitis A

Choi

Song

Han

et al. 2011

Journal of Clinical Virology

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“…Case reports of diabetes developed after HAV infection have led to the suggestion that HAV infection may play a role in the development of diabetes[ 15 , 16 ]. Based on the presence or absence of immunoglobulin G antibody to HAV, the role of HAV in diabetes was excluded in one study[ 17 ].…”

Section: Introductionmentioning

confidence: 99%

Role of hepatitis A virus in diabetes mellitus

Chiu¹,

Chuang²,

Samoa³

et al. 2021

WJD

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BACKGROUND Although much information is available regarding hepatitis C virus infection and diabetes, less is known about the relationship between hepatitis A virus (HAV) infection and diabetes. AIM To examine the roles of HAV in diabetes risk . METHODS This cross-sectional study population included data from the National Health and Nutrition Examination Survey collected between 2005-2012. Adult subjects (≥ 20 years old) with available body mass index measurements, defined diabetes status, history of HAV vaccination, and HAV serology were included. HAV vaccination was based on self-reported history. Successful HAV immunization was defined as the presence of both vaccination and anti-HAV antibody. HAV infection was defined by the absence of vaccination but presence of anti-hepatitis A antibody. The odds ratio (OR) for diabetes with 95% confidence intervals (95%CI) was calculated for each HAV status and then adjusted for covariates. Sensitivity tests, based on different definitions of diabetes, were performed to verify the results. RESULTS Among 19942 subjects, 4229 subjects (21.21%) received HAV vaccination and HAV antibody was present in 9224 subjects (46.25%). Although HAV infection was associated with an increased risk of diabetes (OR: 1.13; 95%CI: 1.08-1.18), HAV vaccination was not associated with diabetes (OR: 1.06; 95%CI: 0.95-1.18), and successful HAV immunization had no impact on the risk of diabetes (OR: 1.11; 95%CI: 0.97-1.27). Thus, HAV infection was an unlikely cause of diabetes. Alternatively, in non-vaccinated subjects, diabetes increased the risk of HAV infection by 40% (OR: 1.40, 95%CI: 1.27-1.54). CONCLUSION An association between HAV infection and diabetes is observed which is best explained by an increased risk of HAV infection in diabetic patients. Diabetic subjects are more susceptible to HAV. Thus, HAV vaccination is highly recommended in diabetic patients.

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Hepatitis A-Induced Diabetes Mellitus, Acute Renal Failure, and Liver Failure

Cited by 8 publications

References 15 publications

Complicated Hepatitis A Virus Infection: A Report of Three Cases from Single Tertiary Referral Center

Complicated Hepatitis A Virus Infection: A Report of Three Cases from Single Tertiary Referral Center

Clinical features and outcomes of acute kidney injury among patients with acute hepatitis A

Role of hepatitis A virus in diabetes mellitus

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