Hepatitis B and C

Abstract

Synopsis Provide a brief summary of your article (100 to 150 words; no references or figures/tables). The synopsis appears only in the table of contents and is often used by indexing services such as PubMed Chronic viral hepatitis continues to be a global health threat and a financial burden. Hepatitis B and C viruses (HBV and HCV) are the most common causes of chronic viral hepatitis in the United States. The majority of cases are asymptomatic during childhood and young adulthood. Cirrhosis and hepatocellular carcinoma are rare during childhood but commonly expected in adulthood. Efforts from worldwide health organizations, pharmaceutical industries, and clinical and research institutions have resulted in much new knowledge, very effective therapy for HCV-infected children and the promise of new effective therapies for HBV-infected children. For HCV-infected children the current standard of care is pegylated interferon and ribavirin but clinical trials with highly effective direct acting antiviral agents are currently underway in the pediatric age group. There are currently 5 FDA-approved agents for HBV-infected children: alpha-interferon, lamivudine, adefovir, tenofovir, and entecavir. However treatment with these agents seldom results in a functional cure and more effective therapies are urgently needed

Frequency and Associated Risk Factors of Hepatitis B Virus and Hepatitis C Virus Infections in Children at a Hepatitis Prevention and Treatment Clinic in Lahore, Pakistan

“…The likelihood of maternal HCV transfer to a newborn is <5% [18][19][20]. However, it was not possible to determine the frequency of vertical transmission of the virus to the 66 HCV-positive children in this study because maternal HCV status was not known, and laboratory tests were not performed during early infancy.…”

Seroprevalence of Hepatitis B Virus, Hepatitis C Virus and Human Immunodeficiency Virus in Children Undergoing Endoscopy in Our Pediatric Gastroenterology Clinic

“…Clinical findings tend to change according to the type of the virus and age of the patient. Although HBV and HCV infections in children are asymptomatic, there is a risk of cirrhosis and hepatocellular carcinoma development (6).…”

Screening for hepatitis b and c viral infections among pregnant women attending the Bolan Medical Complex Hospital and Sandeman Provincial Civil Hospital Quetta, Pakistan.

“…Hepatitis B virus (HBV) and hepatitis C virus (HCV) infections are a worldwide burden to public health. [1][2][3] Infected people have an increased risk of developing potentially life-threatening hepatic diseases such as cirrhosis, hepatocellular carcinoma (HCC) and liver decompensation. HBV and HCV infections are the principal cause of liver-related deaths 4 , with co-infection boosting the severity of hepatic ailment and enhancing risk for progression to HCC.…”