Hepatitis B and Hepatitis C Viral Infections in Patients with Chronic Lymphocytic Leukemia

Minuk, Gerald Y.; Lerner, Betty; Gibson, Spencer B.; Johnston, James B.; Uhanova, Julia; Andonov, Anton; Wu, Jun

doi:10.1155/2014/780350

Cited by 7 publications

(4 citation statements)

References 31 publications

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“…The overall prevalence for hepatitis B virus infection in study participants [(13.97%, 95% CI: 10.61–18.19)] was similar to that estimated for the adult population in Brazil [11.6% (95% CI: 10.7–12.4)] 18 . On the other hand, when comparing the prevalence of HBV due to oncohematologic disease, with studies conducted in countries with similar endemicity to Brazil, the frequency found in patients with chronic lymphoid leukemia [29.17% (95% CI: 14.92%–49.17%)] was almost five times greater than that found in patients with the same disease in Canada [6.3% (IC 95%: 3.79–10.31)] 19 . For patients with non-Hodgkin lymphoma, the prevalence estimated in this study [17.17% (95% CI: 11.01–25.79)] was higher than that found in 554 cases in eight Western European countries [9.9% (95% CI: 7.71–12.7)], 20 however, lower than that found in Italy in 570 NHL carriers (24%) 21 .…”

Section: Discussionmentioning

confidence: 96%

Hepatitis B virus infection among oncohematologic disease patients in Central Brazil: prevalence, risk factors and immunization

Pessoni

Marinho

Carneiro

et al. 2019

Hematology, Transfusion and Cell Therapy

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Introduction Carriers of oncohematological diseases are at high risk for hepatitis B virus (HBV) infection. Objective and method To investigate the epidemiology of HBV infection in Goiânia, Central Brazil, 322 individuals with oncohematological diseases (leukemias, Hodgkin lymphoma and non-Hodgkin lymphoma) were interviewed and blood samples were collected for the detection of serological markers of HBV-DNA by polymerase chain reaction (PCR). Medical records of participants were also reviewed. Results Non-Hodgkin’s lymphomas ( n = 99) and chronic myeloid leukemia ( n = 108) were the most frequent oncohematological diseases. The overall prevalence of HBV was 13.97% (45/322). Of the total participants, 8.69% (28/322) presented isolated positivity for anti-HBs, suggesting low vaccine coverage. HBV-DNA was detected in 25% (1/4) of HBsAg positive samples and in 25% (3/12) of anti-HBc isolated, suggesting HBV occult infection. All samples were identified as subgenotype A1. Entries in patient records and the findings of this investigation suggest anti-HBc seroconversion during oncologic treatment. Age 50 years or over and use of a central catheter during therapy were associated with HBV exposure. Conclusion The low frequency of hepatitis B immunized individuals, detection of HBV DNA in HBsAg negative samples, and the suggestion of HBV exposure during treatment evidenced the potential for health-related viral dissemination in people with oncohematological diseases in our region, reinforcing the importance of serological monitoring, vaccination against hepatitis B, and adoption of strict infection control measures in these individuals.

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Section: Discussionmentioning

confidence: 96%

Hepatitis B virus infection among oncohematologic disease patients in Central Brazil: prevalence, risk factors and immunization

Pessoni

Marinho

Carneiro

et al. 2019

Hematology, Transfusion and Cell Therapy

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“…One of the most serious complications of CLL is a transformation into DLBCL, also called Richter’s syndrome (RS). EBV infection is clearly involved in that progression, but HBV or HCV infection after CLL diagnosis do not seem have a prognostic effect [ 40 , 41 , 42 ]. However, one Chinese study proposed a clinical model in which HBV infection status was associated with time-to-treatment and overall survival in CLL [ 43 ].…”

Section: Mini-review and Discussionmentioning

confidence: 99%

The Pivotal Role of Viruses in the Pathogeny of Chronic Lymphocytic Leukemia: Monoclonal (Type 1) IgG K Cryoglobulinemia and Chronic Lymphocytic Leukemia Diagnosis in the Course of a Human Metapneumovirus Infection

Barben

Putot

Mihai

et al. 2021

Viruses

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Background: Type-1 cryoglobulinemia (CG) is a rare disease associated with B-cell lymphoproliferative disorder. Some viral infections, such as Epstein–Barr Virus infections, are known to cause malignant lymphoproliferation, like certain B-cell lymphomas. However, their role in the pathogenesis of chronic lymphocytic leukemia (CLL) is still debatable. Here, we report a unique case of Type-1 CG associated to a CLL transformation diagnosed in the course of a human metapneumovirus (hMPV) infection. Case presentation: A 91-year-old man was initially hospitalized for delirium. In a context of febrile rhinorrhea, the diagnosis of hMPV infection was made by molecular assay (RT-PCR) on nasopharyngeal swab. Owing to hyperlymphocytosis that developed during the course of the infection and unexplained peripheral neuropathy, a type-1 IgG Kappa CG secondary to a CLL was diagnosed. The patient was not treated for the CLL because of Binet A stage classification and his poor physical condition. Conclusions: We report the unique observation in the literature of CLL transformation and hMPV infection. We provide a mini review on the pivotal role of viruses in CLL pathophysiology.

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“…[ 17 , 28 ] In a study, it was reported that HBV or HCV infections do not play an important role in the pathogenesis or course of CLL. [ 29 ] We included CLL patients as the control group because HBV or HCV infections were known as not to play an important role in the pathogenesis of CLL. We found HBs Ag positivity statistically higher in CLL patients.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of HBV, HCV, and HIV seroprevalence in patients with plasma cell disorders

Mert¹,

Merdin

Çakar

et al. 2020

Medicine

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Hepatitis B (HBV) and hepatitis C (HCV) viruses are hepatotropic and lymphotropic viruses that can proliferate either in lymphocytes and monocytes or hepatocytes. The aim of this study was to evaluate the seroprevalence of HBV, HCV, and human immunodeficiency virus ( HIV ) in patients with plasma cell disorders. We also aimed to compare patients with plasma cell disorders and chronic lymphocytic leukemia (CLL) in terms of HBV, HCV, and HIV seropositivity. This is a retrospective study. The patients who had patient file in the Multiple Myeloma Outpatient Unit of our hospital and were followed in our outpatient unit between January 1, 2012 and September 15, 2019, with diagnoses of either of the plasma cell disorders were included in the study. In addition, 272 CLL patients who were admitted to the Leukemia Outpatient Unit of our hospital were also enrolled in the study. The 2 disease groups were compared in terms of HBV, HCV, and HIV seropositivity. A statistically significant relationship was found between disease groups according to hepatitis B surface antigen ( P < .05). Hepatitis B positivity were found to be more common in CLL patients. There was also a statistically significant relationship between the disease groups in terms of hepatitis B e antigen positivity ( P = .001). We found that hepatitis B surface antigen positivity rate in CLL patients was higher than in patients with plasma cell disorders. Seroprevalence of HBV, HCV, and HIV was found to be very low in patients with plasma cell disorders.

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Hepatitis B and Hepatitis C Viral Infections in Patients with Chronic Lymphocytic Leukemia

Abstract: The results of the present study do not support the hypothesis that HBV or HCV infections play an important role in the pathogenesis or course of chronic lymphocytic leukemia.

Cited by 7 publications

References 31 publications

Hepatitis B virus infection among oncohematologic disease patients in Central Brazil: prevalence, risk factors and immunization

Hepatitis B virus infection among oncohematologic disease patients in Central Brazil: prevalence, risk factors and immunization

The Pivotal Role of Viruses in the Pathogeny of Chronic Lymphocytic Leukemia: Monoclonal (Type 1) IgG K Cryoglobulinemia and Chronic Lymphocytic Leukemia Diagnosis in the Course of a Human Metapneumovirus Infection

Evaluation of HBV, HCV, and HIV seroprevalence in patients with plasma cell disorders

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