Hepatitis B-Associated Symptomatic Iron Overload, with Complete Resolution after Nucleoside Analogue Treatment

Tey, Tze Tong; Yiu, Richard; Leow, Wei Qiang

doi:10.1155/2021/8407257

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Etiologies Of Secondary Iron Overload and Their Pathophysiol...1

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2023

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“… 94 Another case report demonstrated complete resolution of iron overload symptoms and almost normalization of ferritin level with nucleoside analogue treatment. 95 …”

Section: Etiologies Of Secondary Iron Overload and Their Pathophysiol...mentioning

confidence: 99%

Secondary Iron Overload and the Liver: A Comprehensive Review

Pinyopornpanish¹,

Tantiworawit²,

Leerapun³

et al. 2023

J Clin Transl Hepatol

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Iron overload is a condition involving excessive iron deposit in various organs, the liver being the main target organ for iron deposition and overload which are associated with significant liver morbidity and mortality. Iron overload can be categorized into primary and secondary causes. Primary iron overload, so-called hereditary hemochromatosis, is a wellrecognized disease with available standard treatment recommendations. However, secondary iron overload is a more diverse disease with many unclear areas to be explored. Secondary iron overload is more prevalent than primary iron overload and occurs as a consequence of various causes which differ significantly across geographic regions. The main causes of secondary iron overload are iron-loading anemias, and chronic liver disease. The liver-related outcomes, patient outcomes, and treatment recommendations in these patients differ depending on the cause of iron overload. This review summarizes the causes, pathophysiology, liver-related outcomes, disease outcomes, and treatments of secondary iron overload.

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“… 94 Another case report demonstrated complete resolution of iron overload symptoms and almost normalization of ferritin level with nucleoside analogue treatment. 95 …”

Section: Etiologies Of Secondary Iron Overload and Their Pathophysiol...mentioning

confidence: 99%