Hepatitis B e Antigen Negative Chronic Hepatitis in Indian Patients : A Reality

Lahiri, KK; Sahni, A.K.; Gupta, R.M.; Duhan, SD; Kapila, K; Jena, J. K.

doi:10.1016/s0377-1237(07)80004-9

Cited by 4 publications

(6 citation statements)

References 13 publications

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“…These groups of patients are mostly asymptomatic and study also revealed that asymptomatic subjects with incidental detection of hepatitis B surface antigen (HBsAg),usually have a benign non- 15 progressive course . In our study majority of patients were in HBeAg negative chronic infection 66.4% (s79) not requiring treatment, similar observation was also reported by 8 Balasubramanian et al In this group of patients were having normal bilirubin, normal ALT and low or undetected HBV DNA 9 level comparable to other study also . So in this group of patients, no need of antiviral therapy unless significant fibrosis detected by liver biopsy or other non-invasive tests.…”

Section: Discussionsupporting

confidence: 90%

“…Majority of patients were in the age group of 30-60 years 51.3% (61). Balasubramanian et al also reported male preponderance in their study with mean age of men was 40 years and of women 8 was 34 years . Shrestha SM et al, in their prevalence study also reported male predominance but highest prevalence of CHB infection among age groups of 6-15 years compared to 30-60 5 years in our study The difference in age group might be explained as our was hospital based study, serological test for HbsAg only done when indicated as compared to their community based prevalence study.…”

Section: Discussionmentioning

confidence: 60%

“…In present study, possible mode of transmission was unknown among majority of patients 90.8 % (101). Vertical transmission was reported in 6.7% (8). Shrestha SM alsoreported perinatal…”

Section: Resultsmentioning

confidence: 96%

See 2 more Smart Citations

Spectrum of Hepatits B Infection Among Patients Attending Liver Unit in Nepalgunj Medical College – Kohalpur

Khadka¹,

Kc²,

Karki³

et al. 2018

J. Nepalgunj Med. College

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Introduction: Hepatitis B infection is a global problem. Hepatitis B virus (HBV) infection related liver disease is also not an uncommon problem in our country too. Reports regarding pattern of chronic HBV infection are also lacking. The aim of the present study was to determine the spectrum of chronic HBV infection among patients attending the liver clinic in a tertiary care center. Method: A hospital based descriptive cross-sectional study was carried out in Liver unit of Nepalgunj Medical College, Kohalpur, from April 2018 to November 2018. All patients with HBsAg positive were further tested for HBeAg, HBeAb, HBV DNA quantitative and liver function test. Ultrasound examination was advised for any evidence of chronic liver disease. Staging was done according to viral serology, liver biochemistry and ultrasonography of liver Results: Total patients enrolled were 119. Majority of patents were in between 30-60 years (51.3%) with male predominance 59.7%. Most of patients were in the stage of HBeAg negative chronic infection 66.4% with normal transaminase and HBV DNA <2000 IU/ML. Majority of patients having unknown source of infection 90.8%. Incidental detection (67.2%) was common mode of detection. Conclusions: Majority of patients were in HBeAg negative chronic hepatitis B infection phase with normal transaminase and low HBV DNA not requiring treatment.

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Section: Discussionsupporting

confidence: 90%

Section: Discussionmentioning

confidence: 60%

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Spectrum of Hepatits B Infection Among Patients Attending Liver Unit in Nepalgunj Medical College – Kohalpur

Khadka¹,

Kc²,

Karki³

et al. 2018

J. Nepalgunj Med. College

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“…Detection of HBV-DNA was carried out by in-house qualitative polymerase chain reaction (PCR) amplifying the 5-prime end of pre-core and core regions of the HBV genome (nucleotide positions 1730-2388) using assay steps described previously by Lahiri et al 21 Briefly, the PCR primers used were primer 1 (forward) 5′-CTG-GGA-GGA-GTT-GGG GGA-GGAGAT-T-3′ and primer 2 (reverse) 5′-GGC-GAG-GGA-GTT-CTT-CTT-CTAGGG-G-3′. The PCR cycling conditions were as follows: Initial denaturation at 94°C, followed by 30 cycles of denaturation (94°C × 1 minute), primer annealing (50°C × 1 minute), extension (72°C × 2 minutes), and final extension at 72°C × 7 minutes.…”

Section: Methodsmentioning

confidence: 99%

Prevalence of occult hepatitis B amongst Indian human immunodeficiency virus type 1 infected individuals—a pilot study

Sen

Panda

Shanmuganandan

et al. 2012

Medical Journal Armed Forces India

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CONCLUSIONOccult HBV infections may contribute to chronic liver damage, and associated reactivation amongst immunocompromised individuals, HIV-1 infected being a subset of them. 'Anti-HBc' testing followed by HBV-DNA detection by PCR can be utilised for such populations to detect OBIs. Early detection of hepatitis B viraemia will be important for deciding the antiviral therapeutic protocol so as to avoid evolution of antiviral resistance in the circulating HBV strains in HIV-1 infected individuals harbouring OBIs. MJAFI 2012;68:16-19

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“…In another article published in this journal, Lahiri et al [12] have reported that HBeAg negative chronic hepatitis B is present in upto 8.3% of patients with chronic hepatitis B virus infection. HBeAg and HBV-DNA are markers of replication of HBV.…”

Section: H Epatitis B Virus (Hbv) Infection Is a Health Problemmentioning

confidence: 99%