“…The most common VEM was the triple mutation rtV173L + rtL180M + rtM204I/V, found in the Pol gene. This suite of mutations was identified in 14 studies [ 12 , 13 , 20 , 44 , 50 – 55 , 58 – 60 , 62 ], at a pooled prevalence of 4% (57/1462). Another significant VEM, sG145K/R [ 16 ], was identified in six studies [ 12 , 42 , 47 , 57 , 60 , 62 ] and sM133L/T, associated with VEM, immunoglobulin and diagnostic escape mutation [ 12 , 48 ], was identified in seven studies [ 12 , 41 , 47 , 48 , 57 , 62 , 70 ] ( Fig 2 ).…”