Hepatitis B infection in the rural area of Dschang, Cameroon: seroprevalence and associated factors

Tadongfack, Thomas Djifack; Keubo, François Roger Nguépy; Bianke, Patrice

doi:10.11604/pamj.2020.36.362.17787

Cited by 6 publications

(8 citation statements)

References 13 publications

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“…Based on ethnicity, the HBV seroprevalence was 36.7% in Cameroonians. Noted that more than 90% of patients were not vaccinated against HBV infection, and this is consistent with a study conducted in Bamenda and Dschang, Northwest and Western regions of Cameroon [28,29]. Thus, the absence of HBV vaccine coverage could explain this high seroprevalence rate found here.…”

Section: Discussionsupporting

confidence: 92%

COVID-19 and Comorbidities in Douala, Cameroon

Loteri

Sobgui²,

Foko³

et al. 2022

IJTDH

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Aims: Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome Coronavirus 2 (SARS-CoV-2) still negatively impacting the world. This study aimed at determining the prevalence of COVID-19 and comorbidities, associated factors, and evaluating the impact of these comorbidities on COVID-19 patients. Study Design: Cross-sectional hospital-based study. Place and Duration of Study: From January to March 2022, the present study was conducted at four health facilities in Douala town (Littoral Region, Cameroon). Methodology: Anthropometric, bioimpedance, physiological, blood and nasopharyngeal samples were used for diagnosing COVID-19, hepatitis B virus, diabetes, obesity and hypertension. SARS-CoV-2 genome were detected by retrotranscriptase quantitative polymerase chain reaction. Data were analyzed with StatView v5 and GraphPad v5.03 software, and statistical significance was set at p < 0.05. Results: A total of 178 patients, 139 Cameroonian and 39 foreigners, were finally included in the study. Lower COVID-19 vaccination coverage was seen in Cameroonians compared to foreigners (25.2% vs 43.6%, P = .02). No COVID-19 infection cases were found. The overall prevalence of diabetes, hypertension, obesity and HBV was 11.2%, 17.9%, 28.1% and 36.5%, respectively. Nearly 35% of patients were diagnosed with at least two of these comorbidities that significantly impacted on anthropometric, bioimpedance and physiological parameters. The risk of past COVID-infection was increased by 1.06 (95%CI 1.00 – 1.10, P = .03) and 2.81 (95%CI 1.65 – 5.77, P = .04) with one-unit increase in age and BMI, respectively. In contrast, risk of past COVID-19 infection was decreased by 94% (AOR = 0.06, 95%CI 0.01 – 0.76, P = .03) in foreigners compared to Cameroonians. Conclusion: This study outlines the importance to manage comorbidities in context of COVID-19 in Cameroon. Further studies should be conducted with more documented investigations about their epidemiology and impact on the natural history of COVID-19 in the country.

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Section: Discussionsupporting

confidence: 92%

COVID-19 and Comorbidities in Douala, Cameroon

Loteri

Sobgui²,

Foko³

et al. 2022

IJTDH

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“…The statistically significant association between traditional operation or scarification and HBV has also been reported in studies in Africa 21,29 . Traditional operations are common in Africa and involve procedures such as tooth extraction, abortion, injections, incising and draining abscesses, uvulectomy, circumcision, inguinal hernia surgery, non‐invasive cataract luxation and surgery on closed and open fractures 30 .…”

Section: Discussionmentioning

confidence: 71%

“…The statistically significant association between traditional operation or scarification and HBV has also been reported in studies in Africa. 21,29 Traditional operations are common in Africa and involve procedures such as tooth extraction, abortion, injections, incising and draining abscesses, uvulectomy, circumcision, inguinal hernia surgery, non-invasive cataract luxation and surgery on closed and open fractures. 30 In some parts of Africa, cutting out the primary canine tooth buds of infants and toddlers is used as a means of treating or preventing diarrhoea or difficult breastfeeding that is commonly believed to be caused by a worm that lives in the base of the tooth.…”

Section: Ta B L E 3 Prevalence Of Anti-hepatitis C Virus (Hcv) By Age...mentioning

confidence: 99%

Factors associated with hepatitis B and C among adults in Buea, Cameroon: A community‐based cross‐sectional study

Tazinkeng

Teuwafeu

Asombang

et al. 2022

Liver International

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Introduction: Viral hepatitis is a major cause of death in Africa. A paucity of community-based studies on the determinants of viral hepatitis in Africa impedes efforts to appropriately target prevention, screening, and treatment interventions. We assessed factors associated with hepatitis B virus (HBV) and hepatitis C virus (HCV) in a semi-urban health district in Cameroon. Methods: We conducted a community-based, cross-sectional study from 28 February to 15 May 2021 in the Buea Health District in Buea, Cameroon. We recruited a sample of consenting individuals aged over 15 years old. Participants were surveyed for factors associated with HBV/HCV and were screened for HBV surface antigen (HBsAg) and HCV antibody using rapid point-of-care tests. We performed univariable and multivariable logistic regression analyses to identify factors associated with HBsAg and HCV seropositivity. Results:We screened 1144 participants (66% female) with a median age of 30 years (IQR: 23-44). HBsAg prevalence was 5.7% (95%CI: 4.5-7.2%) and HCV seropositivity was 1.9% (95%CI: 1.3-2.9%). Three people (0.3%) were seropositive for both HBsAg and HCV antibody. Male sex (adjusted OR [aOR] = 2.31; 95%CI: 1.28-4.18) and a history of traditional operation or scarification (aOR = 2.87; 95%CI: 1.67-4.92) were associated with HBsAg. None of the assessed factors was significantly associated with HCV antibody. Conclusion:Men and participants with a history of traditional operation and scarification had higher odds of HBsAg. We did not observe any associations with HCV seropositivity. Prevention and screening efforts among adults in this setting should prioritize men and those with a history of traditional operation and scarification.

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“…Indeed, a retrospective study in China showed that HBV infection increases with age, with an adjusted odds ratio of 11.61 for people more than 21 years old. Similarly, a study conducted in Dschang revealed that age, level of education and occupation are all associated with hepatitis B [19]. People in the 17-31 age range were found to be more exposed to HBV, with a prevalence rate of 12.64%.…”

Section: Discussionmentioning

confidence: 90%

“…Patients having tested positive for viral hepatitis more than 6 months ago, and those who stated that they suffered from cirrhosis, fibrosis, steatosis, and liver failure before the study were considered as patients with a chronic liver disease. The minimum sample size (174 subjects) to be used for this study was calculated by the Lorentz formula using the current HBV prevalence (12.75%) in the Adamawa region [19] with a 0.05 degree of precision and 95% confidence level. For more precision, a higher sample size of 225 was considered.…”

Section: Methodsmentioning

confidence: 99%

Seroprevalence, risk factors and impact of dengue fever/hepatitis B coinfection on liver function parameters in Cameroonian patients

Galani¹,

Babai²,

Ngakou³

2022

ceh

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Introduction: Dengue and hepatitis B are viral infections endemic to tropical areas with liver consequences. However, coinfection cases have been poorly documented worldwide and especially on the African continent. This study aimed at analysing the seroepidemiology of dengue-hepatitis B co-infection in patients recruited at the Regional Hospital of Ngaoundere (Cameroon). Material and methods: A cross-sectional study was conducted among 225 patients, aged 15-55 years, enrolled at the Laboratory service of Ngaoundere Regional Hospital from 25 September to 10 December 2021. HBsAg and dengue infection were diagnosed using the serological rapid tests. Part of the blood samples was used to quantify lipid profile and liver function parameters. Results: Of the 225 patients recruited, 22.22% (50) tested positive for hepatitis B and 18.18% (38/202) were positive for dengue fever, with a dengue-hepatitis B coinfection rate of 4.95% (10/202). Coinfected patients were not significantly associated with liver injury compared to monoinfected patients. However, they displayed a higher risk of presenting abnormal γ-glutamyltransferase (γ-GT) (RR = 1.74, 90% vs. 51.51%) and alanine aminotransferase (ALT) values (RR = 1.52, 60% vs. 39.39%) compared to the monoinfected group. Also, there was no difference in total and direct bilirubin between patient groups. The mean triglyceride and low-density lipoprotein (LDL) cholesterol levels and coronary heart index values were higher in the coinfected group than in the monoinfected group, but without significance. Conclusions: Taken altogether, these findings suggest that the presence of hepatitis B in dengue patients may slightly affect the liver's metabolic functions. Clinical surveillance of this coinfection is therefore required to avoid further liver complications.

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Hepatitis B infection in the rural area of Dschang, Cameroon: seroprevalence and associated factors

Cited by 6 publications

References 13 publications

COVID-19 and Comorbidities in Douala, Cameroon

COVID-19 and Comorbidities in Douala, Cameroon

Factors associated with hepatitis B and C among adults in Buea, Cameroon: A community‐based cross‐sectional study

Seroprevalence, risk factors and impact of dengue fever/hepatitis B coinfection on liver function parameters in Cameroonian patients

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