Hepatitis B-related sequelae. Prospective study in 1400 hepatitis B surface antigen-positive Alaska native carriers

McMahon, Brian J.; Alberts, Steven R.; Wainwright, Robert B.; Bulkow, Lisa; Lanier, Anne P.

doi:10.1001/archinte.150.5.1051

Cited by 182 publications

(165 citation statements)

References 14 publications

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“…[16][17][18][19] It depends on a number of factors, including the timing of initial infection and the extent of viral replication. 9 An estimated 20-40% of people with chronic HBV infection (HBsAg positive) have evidence of replicative disease as determined by presence of HBeAg and/or high-level HBV DNA.…”

Section: Viruses and Bacteriamentioning

confidence: 99%

Estimates of chronic hepatitis B virus infection in Australia, 2000

O’Sullivan

Gidding

Law

et al. 2004

Australian and New Zealand Journal of Public Health

101

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Objectives: To estimate the prevalence of chronic hepatitis B virus (HBV) infection in Australia and attributable proportions associated with specific demographic groups at higher risk of infection. Methods: Two methods were used to estimate prevalence of HBV surface antigen (HBsAg): (1) Population-based: results of a national serosurvey using sera collected opportunistically from laboratories across Australia were used for 1-59 year olds, with the HBsAg prevalence for 50-59 years extrapolated to the population aged 60 years and over; (2) Risk group-based: estimates for selected high-risk groups (injecting drug users, homosexual men, Indigenous Australians and people born in highprevalence countries), using source data from antenatal HBV screening in central Sydney, HBV prevalence studies, and estimates for low-risk groups (first-time blood donors) were combined proportionally to their representation in the population. Results: Prevalence of HBsAg in the national serosurvey increased, with age, from 0.0% for 1-4 and 5-9 year olds to 1.3-1.8% for the 40-49 year age group. Australian population HBsAg prevalence based on minimum and adjusted estimates from this serosurvey were 91,500 (0.49%) and 163,000 (0.87%) infections, respectively. The risk group method estimated an Australian HBsAg prevalence of 88,000 infections (0.47%). Approximately 50% of people with chronic HBV infection were estimated to be immigrants from either South-East Asia (33.3%) or North-East Asia (16.2%). Conclusion:The range of estimates for chronic HBV infection in Australia is broad, reflecting the uncertainty in source data. A national blood survey encompassing a large and representative population sample may help to provide more accurate estimates. A large proportion of people with chronic HBV infection are Asian born.

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Section: Viruses and Bacteriamentioning

confidence: 99%

Estimates of chronic hepatitis B virus infection in Australia, 2000

O’Sullivan

Gidding

Law

et al. 2004

Australian and New Zealand Journal of Public Health

101

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“…16 The incidence of HCC in individuals with chronic hepatitis B is as high as 0.46% per year. [19][20][21][22] Cirrhosis is also a risk factor for HCC, irrespective of etiology. The annual risk of developing HCC in cirrhosis is between 1% and 6%.…”

Section: The Target Population Must Be Easily Identifiablementioning

confidence: 99%

“…12,21,29,[41][42][43][44] No study has directly addressed the question of whether surveillance for HCC should or could be restricted to individuals over a certain age limit. The risk of HCC in HBV carriers is negligible before the age of 30.…”

Section: The Target Population Must Be Easily Identifiablementioning

confidence: 99%

Screening for hepatocellular carcinoma

1998

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“…Approximately 1.25 million Americans are chronically infected with hepatitis B [2,3] and are at increased risk for cirrhosis [4,5], hepatic decompensation [6,7], and hepatocellular carcinoma [8][9][10]. In a sample of the general U.S. population, the prevalence of chronic hepatitis B virus (HBV) infection was found to be 0.4% [11].…”

Section: Introductionmentioning

confidence: 99%

Seroepidemiology of hepatitis B virus infection: analysis of mass screening in Hawaii

Tsai

Holck

Ricalde³

2008

Hepatol Int

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Background Although hepatitis B seroprevalence has been studied extensively in California and New York, detailed information for other high-risk areas in the United States is lacking. To study current prevalence and risk for hepatitis B virus (HBV) infection in Hawaii, we analyzed cross-sectional data from Hawaii residents screened between July 2003 and April 2006. Methods We retrospectively reviewed the screening records of 3,989 participants recruited at health fairs and clinics. Prevalence and risk factors for HBV infection were estimated using univariate and multivariate logistic regression models. Results Total prevalence of hepatitis B surface antigen (HBsAg) was 3.6%. Gender, age, and ethnicity were independently associated with HBsAg seropositivity. In a multivariate logistic regression model, males were at increased risk for HBsAg compared with females (odds ratio [OR] = 1.53, 95% confidence interval [CI]: 1.09-2.16) and persons aged 70 years or older were less likely to test positive than those younger than 30 (OR = 0.25, 95% CI: 0.11-0.61). In addition, multivariate ORs of HBsAg seropositivity were 3.24 (95% CI: 1.04-10.09), 4.13 (95% CI: 1.66-10.29), and 7.47 (95% CI: 2.52-22.11) for Vietnamese, Chinese, and Pacific Islanders, respectively, compared with Whites. Conclusions This study furthers current knowledge of HBV epidemiology in areas with large populations of highrisk immigrants and demonstrates the relevance of screening programs for hepatitis B.

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Hepatitis B-related sequelae. Prospective study in 1400 hepatitis B surface antigen-positive Alaska native carriers

Cited by 182 publications

References 14 publications

Estimates of chronic hepatitis B virus infection in Australia, 2000

Estimates of chronic hepatitis B virus infection in Australia, 2000

Screening for hepatocellular carcinoma

Seroepidemiology of hepatitis B virus infection: analysis of mass screening in Hawaii

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