Hepatitis B sero-prevalence among hematology patients: importance of Anti-HbcAb and efficiency of antiviral prophylaxis

Abstract

Objectives: Hepatitis B infection is an important problem in immune suppressed patients. Anti HbcAb is an important marker that shows past exposure to virus. In this study, we retrospectively searched HBV serology among the patients who had Bone Marrow Transplantation (BMT) or chemotherapies (CT) at Medicalpark Izmir Hospital Bone Marrow Transplantation Unit; changes in viral parameters throughout therapy; and tried to find the efficiency of antiviral prophylaxis .
 Methods: We retrospectively evaluated the viral parameters; HbsAg, Anti HbsAb, Anti Hbc IgG, HbeAg, Anti Hbe Ab, HBV DNA, HCV RNA which were carried out before BMT and CT. We grouped the patients as latent HBV infection and inactive carriers .Started antiviral treatment as prophylaxis, monitored the changes in serological parameters and defined HBV related situations.
 Results: A total of 584 patients were evaluated retrospectively. Twenty patients were having latent HBV infection. Ten patients were inactive carriers of HBV. In post-transplant period, the patients were screened for 11 months (1-38 months). None of the patients experienced HBV activation during follow period.
 Conclusion: The best approach in HbcAb positive patients with planned immunosuppressive treatment is the use of anti-viralagents before immune suppression and close monitoring of the patients HBV-related markers .
 Keywords: Hepatitis B; Hematologic Malignancy; stem cell transplantation.

Comparison of Clinical Manifestations and Related Factors of Hepatocellular Carcinoma with Chronic Hepatitis B

“…Individuals infected with HBV typically produce high level of HBcAb, which remain detectable for the duration of their lives; thus, the presence of HBcAb serves as a reliable indicator for evaluating the prevalence of HBV infection within a given population. 54 , 55 …”

“…Individuals infected with HBV typically produce high level of HBcAb, which remain detectable for the duration of their lives; thus, the presence of HBcAb serves as a reliable indicator for evaluating the prevalence of HBV infection within a given population. 54,55 Furthermore, cirrhosis was more common in the CHB patients with HCC, suggesting that cirrhosis may be an important cause of HCC development. Thus, our study analyzed the clinical manifestations of patients with HCC with or without cirrhosis.…”

Editorial I: So, who wins? It is still: NCDs 3; Infections 2

“…[36][37][38][39][40][41][42] The non-communicable diseases theme is then followed by infectious diseases, ranging from HIV, [43][44][45][46][47][48][49] the COVID-19 pandemic, [50][51][52][53][54][55][56][57] and others. [58][59][60][61][62][63][64][65][66] We conclude the issue with a hybrid of papers [67][68][69][70][71][72][73][74][75] akatogo of sorts! Finally, we wish to thank our volunteers; editorial team and board; reviewers, authors, readers; and partners through AJPP and others, who, in one way or another, contributed to the sustainability and growth of AHS, as we continue our struggle to enhance publication of high-quality health science papers in Africa, the diaspora, and beyond.…”