Hepatitis B seroprevalence and anamnestic response amongst Taiwanese young adults with full vaccination in infancy, 20 years subsequent to national hepatitis B vaccination

Su, Fu Hsiung; Cheng, Shu Hsing; Li, Chung‐Yi; Chen, Jong Dar; Hsiao, Chu Yun; Chien, Chih-Ching; Yang, Ya Chuan; Hung, Hsiu Hsing; Chu, Fang

doi:10.1016/j.vaccine.2007.09.013

Cited by 76 publications

(61 citation statements)

References 35 publications

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“…The present result also proved that the humoral immune response of inoculated individuals, as determined by the antigen stimulation of PBMCs, was not related with antibody titer in the serum, which was consistent with previous observations (Leyendeckers et al, 1999;Rosado et al, 2011). On the other hand, assessment of the immune response to HBsAg in vivo showed a positive correlation between previous high antibody titer and memorial anti-HBs response (Su et al, 2007;Eldesoky et al, 2009). The vaccinated individual with a low serum titer of anti-HBs cannot be shown to produce a memory response to a high dose of antigen.…”

Section: R E T R a C T I O Nsupporting

confidence: 91%

Immune memory responses to HBV vaccine 13-18 years after primary vaccination

Hou¹,

Li²,

Wei³

et al. 2015

Genet. Mol. Res.

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ABSTRACT. The aim of this study was to evaluate the immune memory response 13-18 years after an hepatitis B virus (HBV) vaccine by performing a specific in vitro stimulation experiment. Thirty healthy volunteers who had been inoculated 13-18 years ago with the HBV vaccine were collected from the physical examination center. Peripheral blood mononuclear cells were stimulated with 50 ng/mL recombinant HBsAg. An ELISA kit was used for the detection of antibodies that were produced by these cells in vitro. It was found that even 13-18 years after inoculation with the HBV vaccine, an anamnestic antibody response still existed, and was not correlated with the serum antibody levels (r = -0.177, P = 0.377).In conclusion, our data showed that the individuals after inoculation, including those with anti-HBs <10 IU/L as well as those individuals in whom the antibody was not detected, retained immune memory, which may be the main role of memory B cells.

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Section: R E T R a C T I O Nsupporting

confidence: 91%

Immune memory responses to HBV vaccine 13-18 years after primary vaccination

Hou¹,

Li²,

Wei³

et al. 2015

Genet. Mol. Res.

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“…Because the cumulative risk of chronic HBV infection in subjects who did not received hepatitis B immune globulin was low, our results did not support boosting the whole neonatally vaccinated cohort. 5 In our study, the cumulative risk of chronic HBV infection in subjects with maternal hepatitis B e antigen (HBeAg) positivity and high HBsAg titers were 17.8% and 11.1%, respectively. 5 Based on the figures in two empirical studies, 6,7 the…”

Section: Replymentioning

confidence: 71%

“…5 In our study, the cumulative risk of chronic HBV infection in subjects with maternal hepatitis B e antigen (HBeAg) positivity and high HBsAg titers were 17.8% and 11.1%, respectively. 5 Based on the figures in two empirical studies, 6,7 the…”

Section: Replymentioning

confidence: 71%

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Chronic hepatitis B infection in adolescents vaccinated at birth: An alarm bell in favor of the need for a booster?

et al. 2013

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et al. 1 reported that a significant proportion of adolescents born to hepatitis B surface antigen (HBsAg)-positive mothers, who had postnatal hepatitis B immune globulin (HBIG) and hepatitis B vaccine, lost immune memory and developed a HBsAg carrier state. Having maternal hepatitis B e antigen (HBeAg) positivity was the most important determinant for developing chronic hepatitis B.Vaccination has proved to be highly effective in preventing and controlling hepatitis B, carrier rate, and hepatitis B virus (HBV)-related mortality worldwide. Long-term protection studies indicate that vaccine-induced anti-HBs concentrations decline over time, with antibody (Ab) levels falling below the protective threshold (10 mIU/mL) in one third to one half of vaccinees 10-20 years later; however, immunological memory usually persists. 2,3 This is because Ab maintenance after vaccination depends on the number of longlived plasma cells, whereas booster response is a function of memory B cells. Evidence indicates that memory B cells effectively respond to antigen challenge even when Ab falls below the protective level. 4 Thus, booster doses are not needed in immunocompetent individuals to maintain long-term protection.However, failure to develop postbooster anamnestic response has been reported, raising concern that immune memory may wane during the second decade postvaccination. 5,6 In his study, Wu et al. show that 15% of adolescents born to HBsAg/HBeAgpositive mothers who received primary infantile vaccination developed chronic HBV infection. In addition, one sixth of vaccinees were unable to respond to booster vaccination, having lost immunological memory.Individuals who lost immunological memory may become vulnerable to HBV infection, especially in highly endemic regionssuch as some Asiatic countries-where HBsAg carriers are often positive for HBeAg, then highly infectious. Thus, need for a booster in this setting, where risk of acquiring infection and becoming chronic is high, should be considered. If this were the policy, booster should be given before loss of immunological memory occurs.

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“…18,19 Furthermore, immunological memory responses decrease with age after primary immunization. [20][21][22] Consequently, the need for booster vaccination against Hepatitis B has received much attention, [23][24][25] but little is known about the effect of booster vaccination with HepB (CHO) in infants of HBsAg-positive mothers, who have a greater chance to be exposed to hepatitis B virus.…”

Section: Control Of Hepatitis B Also Prevents Hepatitis D Infection mentioning

confidence: 99%

The effects of booster vaccination on hepatitis B vaccine in anti-HBs negative infants of HBsAg-positive mothers after primary vaccination

Yao

Zhu³

et al. 2013

Human Vaccines & Immunotherapeutics

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Hepatitis B seroprevalence and anamnestic response amongst Taiwanese young adults with full vaccination in infancy, 20 years subsequent to national hepatitis B vaccination

Cited by 76 publications

References 35 publications

Immune memory responses to HBV vaccine 13-18 years after primary vaccination

Immune memory responses to HBV vaccine 13-18 years after primary vaccination

Chronic hepatitis B infection in adolescents vaccinated at birth: An alarm bell in favor of the need for a booster?

The effects of booster vaccination on hepatitis B vaccine in anti-HBs negative infants of HBsAg-positive mothers after primary vaccination

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