2010
DOI: 10.1016/j.jhep.2010.01.007
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Hepatitis B surface antigen levels during the natural history of chronic hepatitis B: A perspective on Asia

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Cited by 323 publications
(395 citation statements)
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“…A moderate correlation between serum HBV DNA and serum HBsAg titers was found in the ENH phase, and no correlation was observed in the LR phase. These important results are consistent with previous studies [9,10] and suggest that the control of HBV replication by the immune system does not hamper HBsAg production. In this study, a temporal relationship between HBeAg seroconversion and an increase of prevalence of patients with This is an editorial to the article available at doi:10.1007/s12072-013-9438-z BCP/precore mutations was shown, suggesting that the immune control that occurs during CHB is instrumental in selecting variants defective for HBeAg production.…”
supporting
confidence: 93%
“…A moderate correlation between serum HBV DNA and serum HBsAg titers was found in the ENH phase, and no correlation was observed in the LR phase. These important results are consistent with previous studies [9,10] and suggest that the control of HBV replication by the immune system does not hamper HBsAg production. In this study, a temporal relationship between HBeAg seroconversion and an increase of prevalence of patients with This is an editorial to the article available at doi:10.1007/s12072-013-9438-z BCP/precore mutations was shown, suggesting that the immune control that occurs during CHB is instrumental in selecting variants defective for HBeAg production.…”
supporting
confidence: 93%
“…Two independent groups found that the level of qHBsAg was higher in the immune-tolerant and immune-clearance phases than in the low-replicative phase and in patients with HBeAg(À) disease. 22,23 These discrepancies in qHBsAg across different phases of CHB infection and in correlation between qHBsAg and HBV DNA provide evidence that different pathways exist for HBsAg and HBV DNA production as well as that HBV may integrate into the host genome. In addition, similar published results have demonstrated a good correlation in HBeAg(ĂŸ) patients (r ÂŒ 0.69, P < 0.001), whereas the association between HBsAg production and HBV replication broke down in HBeAg(À) patients (r ÂŒ 0.28, P ÂŒ 0.012); this was assumed to occur when HBsAg was produced from a source other than cccDNA.…”
Section: Discussionmentioning
confidence: 99%
“…22,23 These studies have demonstrated significant differences in qHBsAg across the different phases of HBV infection over a long time period. Moreover, Thompson et al 24 reported differences in the correlations between qHBsAg and HBV DNA in HBeAg(ĂŸ) patients and HBeAg(À) patients in conjunction with qHBeAg.…”
mentioning
confidence: 99%
“…StĂ©phane Chevaliez, 1,2 Christophe HĂ©zode, 2,3 StĂ©phane Bahrami, 4 Marion Grare, 1 and Jean-Michel Pawlotsky 1, 2 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 3…”
Section: Finite Treatment Duration Unlikelyunclassified