Hepatitis B Surface Antigenemia in a Chronic Hemodialysis Program: Lack of Influence on Morbidity and Mortality

Josselson, John; Kyser, Betty A.; Weir, Matthew R.; Sadler, John H.

doi:10.1016/s0272-6386(87)80071-9

Cited by 43 publications

(21 citation statements)

References 23 publications

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“…Data about survival of HBV infected HD patients are still controversial. In a US cohort, HBV infection didn't seem to have an influence on the number of hospitalizations or mortality [22]. In contrast, Jha et al showed that the mortality due to fulminant hepatitis is more frequent in the AgHBs positive patients [23].…”

Section: Discussionmentioning

confidence: 99%

Hepatitis B and C Virus Infection in the Hemodialysis Population from Three Romanian Regions

Schiller

Timar²,

Siriopol³

et al. 2015

Nephron

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Background: After 10 years of systematically nationwide applied measures for reduction of infection risk, in this national prospective observational study, we reassessed the prevalence of hepatitis virus infection prevalence and its influence on the outcome of end-stage kidney disease (ESKD) patients treated with hemodialysis. Methods: Six-hundred ESKD patients (332 men and 268 women, median age 56 years) treated with chronic HD in seven centers from all the historical regions of Romania have been assigned to this study on 1st of November 2010. The aims of this study were to reevaluate the prevalence of the hepatitis B and C virus infection in a HD population from Romania after 10 years of systematically nationwide applied measures for reduction of infection risk and also to assess the impact of these infections on the prognosis of HD patients. Results: HBsAg was positive in 9.5% (n = 57) of the patients, anti-HCV antibodies were detected in 27.3% (n = 164) and 5% (n = 30) were positive for both HBV and HCV infection. The mortality risk was significantly influenced only by age, the presence of coronary artery disease and the 25 OH vitamin D levels. Conclusions: This study shows that the systematically nationwide applied measures for reduction of infection risk significantly decreased HV infection prevalence in HD patients in Romania. The presence of HV infection did not significantly influence the mortality risk in this population.

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Section: Discussionmentioning

confidence: 99%

Hepatitis B and C Virus Infection in the Hemodialysis Population from Three Romanian Regions

Schiller

Timar²,

Siriopol³

et al. 2015

Nephron

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“…Several investigators have observed no significant difference in morbidity or mortality between HBsAg-positive and HBsAg-negative patients undergoing HD treatment in US [17,39]. In contrast, hepatic failure may be a significant cause of death among chronic HD patients in developing countries [40].…”

Section: Natural History Of Hbv Infection In Dialysis Patientsmentioning

confidence: 99%

Hepatitis B Virus Infection in Dialysis Patients

Fabrizi¹,

Martin²

2000

Am J Nephrol

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“…Few studies have addressed the natural history of HBV in the dialysis population. Josselson et al [27] reported no significant differences in death rates, hospitalizations and hospitalized days between HBsAg-positive and -negative patients on maintenance hemodialysis in the US. However, different outcomes were noted in a retrospective study from India [28] .…”

Section: Discussionmentioning

confidence: 99%

Hepatitis B viral infection in maintenance hemodialysis patients: A three year follow-up

Cao¹

2007

WJG

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AIM:To observe the prevalence of hepatitis B virus (HBV) infection in maintenance hemodialysis patients. METHODS:Eighty-eight hemodialysis patients who had been receiving hemodialysis regularly for an average of 39.45 ± 7.57 (range from 36 to 49) mo were enrolled in this study. HBV markers were measured in these patients before hemodialysis and in 100 healthy controls by the chemiluminescent microparticle immunoassay (CMI) method in order to compare the incidence of HBV infection in hemodialysis patients versus normal healthy people. All patients were then divided into two groups: patients positive for HBV markers (i.e. those positive for HBsAg, anti-HBc, HBeAg, anti-HBe, with or without positive anti-HBs) (n = 33), and patients negative for HBV markers (including those only positive anti-HBs) (n = 55). The following information was obtained for all patients: socio-demographic data, number of blood transfusions and some laboratory investigations. After 39.45 ± 7.57 mo follow-up, HBV markers were measured in these patients by CMI. R E S U LT S :T h e i n c i d e n c e o f H B V i n f e c t i o n i n maintenance hemodialysis patients was 37.5%, which was higher than in controls (9%). In the patients positive for HBV markers, there were 13 patients (39.4%) who had a history of blood transfusion, which was more than the number [12 (21.8%), P = 0.04] of patients negative for HBV markers. Eight of the 88 patients negative for HBV markers turned out to be positive, while three of the 33 patients positive for HBV markers turned out to be negative. There was no cirrhosis of the liver or hepatoma occurring in these patients. CONCLUSION:Maintenance hemodialysis patients have a higher risk of HBV infection than the average population. The number of blood transfusions is associated with an increased prevalence of HBV. While it is hard for hemodialysis patients to eliminate HBV, the prognosis of patients with positive HBV markers is good.

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Hepatitis B Surface Antigenemia in a Chronic Hemodialysis Program: Lack of Influence on Morbidity and Mortality

Cited by 43 publications

References 23 publications

Hepatitis B and C Virus Infection in the Hemodialysis Population from Three Romanian Regions

Hepatitis B and C Virus Infection in the Hemodialysis Population from Three Romanian Regions

Hepatitis B Virus Infection in Dialysis Patients

Hepatitis B viral infection in maintenance hemodialysis patients: A three year follow-up

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