Hepatitis B vaccination failure in celiac disease: Is there a need to reassess current immunization strategies?

Leonardi, ﻿Salvatore; Spina, Massimo; Spicuzza, Lucia; Rotolo, Novella; Rosa, Mario La

doi:10.1016/j.vaccine.2009.07.099

Cited by 62 publications

(73 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Therefore, we included 17 randomized clinical trials in the qualitative synthesis. [6][7][8][9][10][11][12][17][18][19][20][21][22][23][24][25][26] Three studies were further excluded because they lacked a control arm; 17-19 2 other studies, reporting both a retrospective and a prospective cohort of patients, were considered only for the retrospective design, since the prospective cohort lacked a control arm. 20,21 As a result, 14 studies were considered for the metaanalysis.…”

Section: Resultsmentioning

confidence: 99%

Immune response to Hepatitis B vaccine in patients with celiac disease: A systematic review and meta-analysis

Opri

Veneri

Mengoli

et al. 2015

Human Vaccines & Immunotherapeutics

View full text Add to dashboard Cite

show abstract

Section: Resultsmentioning

confidence: 99%

Immune response to Hepatitis B vaccine in patients with celiac disease: A systematic review and meta-analysis

Opri

Veneri

Mengoli

et al. 2015

Human Vaccines & Immunotherapeutics

View full text Add to dashboard Cite

show abstract

“…Therefore, they concluded that, in children with CD, the immune response to HBV vaccination may be improved by compliance to the GFD [25]. Leonardi et al [26] in a retrospective report conirmed that CD patients have a lower percentage of response to HBV vaccination than healthy subjects. In fact, they found that 30 (50%) of 60 CD patients were nonresponders to HBV vaccination, compared to 7 (11.6%) of 60 controls.…”

Section: Responses To Vaccinations In Celiac Childrenmentioning

confidence: 99%

“…The failure of CD subjects to respond to HBV vaccination has great importance for public health policies as the nonresponders could be regarded as a reservoir for HBV [20]. The studies that have addressed the relation between CD and HBV vaccination in children are summarized in Table 1 [21][22][23][24][25][26][27][28][29]. In the earliest report involving 26 celiac patients aged 9.2 ± 4.6 years and 18 age-matched controls, receiving the full complement of childhood vaccination (HBV, tetanus, rubella, Haemophilus inluenzae type b), Park et al [21] demonstrated that a signiicantly higher proportion of subjects in the CD group failed to respond to HBV vaccine compared with controls (53.9% versus 11.1%; p < 0.05).…”

Section: Responses To Vaccinations In Celiac Childrenmentioning

confidence: 99%

Celiac Disease and HBV Vaccination

Anania¹,

Olivero²,

Olivero³

et al. 2017

Celiac Disease and Non-Celiac Gluten Sensitivity

View full text Add to dashboard Cite

Celiac disease (CD) is an immune-mediated systemic disorder elicited by gluten and related prolamins in genetically susceptible individuals, characterized by the presence of a variable combination of gluten-dependent clinical manifestations, CD-speciic antibodies, HLA-DQ2 and HLA-DQ8 haplotypes, and enteropathy. Hepatitis B virus (HBV) infection is an important global public health problem that can cause chronic liver disease, and it is associated to a high risk of death from cirrhosis and hepatocellular carcinoma. Since 1982, a safe and efective HBV vaccine has been available, and recommendation for HBV vaccination has been extended to all infants to achieve protection against HBV infection. HBV vaccination is highly efective in eliciting a sustained immune response in immune-competent individuals. However, research papers have suggested that celiac patients may have low rate of protective antibodies after HBV vaccination. The failure of CD subjects to respond to HBV vaccination has great importance for public health policies as the nonresponders could be regarded as a reservoir for HBV. The aim of our work is to revise and to discuss the scarce literature on this ield in order to provide clinical practice guidelines to establish the best surveillance program of response to HBV vaccine in CD pediatric patient.

show abstract

“…47 Testing for celiac disease, HIV or other causes of immune deficiency might be advisable for non-responders. [48][49][50] Recommendations 1. All infants should receive their first dose of hepatitis B vaccine as soon as possible after birth, preferably within 24 hours, followed by two or three doses of hepatitis B vaccines 51 .…”

Section: Antiviral Resistancementioning

confidence: 99%