Hepatitis B viral load in diagnosing different clinical stages of chronic hepatitis B in a tertiary care hospital in North Kerala

Balakrishnan, S.; Moorkoth, Anitha Puduvail; Devi, KL Sarada; Philomina, Beena; Lilabi, MP

doi:10.4103/0972-1282.184756

Cited by 1 publication

(1 citation statement)

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“…Mutant HBV may evolve in chronic infection process, which may aid in immune evasion. [5] HBeAg-negative CHB is defined as: 1. HBsAg positivity and HBeAg negativity for more than 6 months, at least for a year.…”

Section: Discussionmentioning

confidence: 99%

Does Hepatitis B Virus DNA Forecast Chronic Hepatitis in Hepatitis B Surface Antigen-positive Patients?

Pandi,

Kumarasamy

2023

Apollo Medicine

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Introduction: Chronic hepatitis B (CHB) infection is accountable for nearly 240 million cases worldwide. Hepatitis B virus (HBV) has a propensity to show a divergent phase, and isolated measure of high HBV DNA level may not reflect the stage of the disease. In this background, this study was done to detect hepatitis B e antigen (HBeAg) and HBV DNA levels among hepatitis B surface antigen (HBsAg)-positive CHB cases and to determine the stage of disease with viral markers and biochemical parameters such as alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels. Materials and Methods: Blood samples were collected from 50 participants with CHB (HBsAg positive for more than 6 months) tested for HBe Ag by enzyme-linked immunosorbent assay, HBV DNA, ALT, and AST levels. Results: Among the 50 cases, 31 (62%) were HBeAg negative. Among these 31 HBeAg-negative groups, 16 (52%) had HBV DNA levels >2000 IU/mL. In these 16 patients, six had ALT >40IU/mL. Conclusion: HBsAg, HBeAg, ALT levels, and HBV DNA are important markers to determine the clinical stage of the disease. Since it is a chronic disease, patients need long-term follow-up. Further, emergence of viral mutants among vaccinated and those on lamivudine aggravates the existing problem.

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Section: Discussionmentioning

confidence: 99%