Hepatitis B virus DNA–positive, hepatitis B surface antigen–negative blood donations intercepted by anti‐hepatitis B core antigen testing: the Canadian Blood Services experience

O’Brien, Sheila F; Fearon, Margaret; Yi, Qilong; Wang, Fan; Scalia, Vito; Muntz, Irene R; Vamvakas, Eleftherios C.

doi:10.1111/j.1537-2995.2007.01396.x

Cited by 51 publications

(64 citation statements)

References 22 publications

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“…In 2005, a study showed that anti-HBc (core HBV antibody) screening yielded between 1 : 17.800 and 1 : 69.300 HBV infections among HBsAg-negative and HBV-DNA-positive donors [19]. The HBV residual risk was estimated at 1 : 153.000 for the first half of the 2000 decade [20]. A case-control study covering the period between 1997 and 2006 showed that immigration from highly endemic areas was a major risk factor for HBV infection in the first-time donors [21].…”

Section: Developed Countriesmentioning

confidence: 99%

Residual Risk of Hepatitis-B-Infected Blood Donations: Estimation Methods and Perspectives

Kupek

2013

ISRN Infectious Diseases

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Despite a considerable reduction of the risk of HBV-infected blood donation entering blood supply (residual risk) due to improved screening by HBV NAT in the developed countries, the bulk of the people with HBV living in the developing countries still needs to be screened by serologic tests such as HBsAg and anti-HBc. Many of these countries lack resources for implementing NAT and are likely to remain so in the next decade or longer, thus depending on the HBV residual risk monitoring based on serologic testing and corresponding estimation methods. This paper reviews main HBV residual risk findings worldwide and the methods based on serology used for their calculation with repeat donors, as well as their extension to the first-time donors. Two artificial datasets with high (4.36%) and low (0.48%) HBV prevalence were generated to test the performance of five methods: the original incidence/window-period model based solely on HBsAg, its modification by Soldan in 2003, the Müller-Breitkreutz model, the HBsAg yield model, and its extension to include anti-HBc seroconversions within a year. The last model was closest to the true values of residual risk and had smallest variation of the estimates in both high and low prevalence data. It may be used for residual risk evaluation in relatively small samples, such as regional blood banks data.

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Section: Developed Countriesmentioning

confidence: 99%

Residual Risk of Hepatitis-B-Infected Blood Donations: Estimation Methods and Perspectives

Kupek

2013

ISRN Infectious Diseases

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“…En India, considerado un país endémico para la infección por el virus de la hepatitis B, en un estudio llevado a cabo en 2007, durante un periodo de dos años, con un tamaño de 1.027 muestras y reacción de 18,3 % a anti-HBc, se hallaron 21,3 % muestras positivas para ADN (en muestras HBsAg no reactivas y anti-HBc reactivas) (20). Por otro lado, en Canadá, considerado como un país poco endémico para el virus de la hepatitis B, en 2007 se hizo un estudio durante 18 meses en donantes de sangre con doble reacción para anti-HBc (1,13 %), y se hallaron 0,52 % (n=29) positivos para ADN del virus de la hepatitis B, en muestras que eran no reactivas para HBsAg (29).…”

Section: Interpretaciónunclassified

Detección de hepatitis B oculta en donantes de bancos sangre, Colombia 2008-2009

et al. 2011

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Palabras clave: transfusión sanguínea, hepatitis B, bancos de sangre. Colombia. Absence of occult hepatitis B in Colombian blood donorsIntroduction. In Colombian blood banks, screening for the surface antigen of hepatitis B is mandatory in all units collected. Testing of antibody against core antigens is not administered, although this method may be useful to detect donors infected with the hepatitis B virus. Objective. The prevalence of occult hepatitis B was determined by applying a full-serological profile of hepatitis B virus to blood samples of blood donors. Materials and methods. Between April 2008 and October 2009, a prospective cross sectional study was conducted using 628 samples from donors to blood banks located in four Colombian cities. Prevalence for hepatitis B had been previously recorded for these cities. Serological screening was performed for the complete virus; then nucleic acid amplification was tested in sera that were anti-HBc reactive and with a titer of anti-HBs ≤30 mUI/ml. Results. Of the 628 samples tested, 129 met the serological criteria established to be tested nucleic acid amplification. None of them demonstrated evidence of nucleic acid amplification of hepatitis B virus. Conclusions. This is the first study in Colombia to detect the presence of blood donors that may be occult hepatitis B carriers. None was detected.

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“…HBsAg (-), Anti-HBc Total (+) bulunan hastalarda %19'lara varan oranlarda HBV-DNA pozitifliğinin saptanması, bağış kanlarında sadece HBsAg bakılarak HBV taraması yapılmasının yetersizliğini vurgulamaktadır (3) . Anti-HBc IgG taranmasının olası transfüzyon ile geçen HBV enfeksiyonunu önleyebileceğini belirten pek çok çalışma mevcuttur (12)(13)(14)(15) . Ancak anti-HBc IgG reaktif örneklerde değişen oranlarda (%35'e varan) yalancı pozitiflikler de elde edilmektedir.…”

Section: Introductionunclassified

Infectious Agents Transmitted by Blood and Blood Component and Impacts of Nükleik Asit Amplifikasyon Test (NAT)

Savasci¹,

Avcı²

2016

IKSST

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ÖZ Kan ve kan¸bileşenleri ile bulaşan enfeksiyonlar, özellikle viral hepatit virüsleri ve insan immün yetmezlik virüsü¸ (HIV), ABSTRACT Especially viral hepatitis viruses and human immunodeficiency virus (HIV) which are transmitted by the transfusion of blood and blood products have been an important public health problem for a long time in the world. Transfusion of blood and blood products is an ideal, easiest and a simplest route for transmission of infectious diseases. It is known that many infectious agents, either bacterial, viral, parasitic and fungal agents may be transmitted by the transfusion of blood and blood products. Nucleic Asit Amplification Test (NAT) provides additional layer of safety to the blood supply because it allows the detection of infectious agents during their incubation periods. Keywords: blood, blood center, infection, nucleic acid amplification test GİRİŞKan ve kan bileşenleri hayati tehlikeye neden olan birçok hastalık ve travmalarda tedavi amaçlı kullanı-lan bileşenlerdir. Kan ve kan bileşenlerinin tek kaynağının insan olması nedeniyle temini çok zor ve maliyet açısından oldukça pahalı bileşenlerdir. Kan naklinin güvenli bir şekilde yapılması, nakil sonrası ortaya çıkabilecek enfeksiyonların önlenebilmesine bağlıdır. Dünyada her yıl milyonlarca ünite kan ve kan bileşenleri kullanılmakta ve alıcıların bir kısmın-da transfüzyona bağlı enfeksiyonlar ortaya çıkmakta-dır. Kan ve kan bileşenlerinin kullanımı aracılığıyla bağışçıda mevcut enfeksiyon etkeninin alıcıya aktarılması tamamıyla engellenememektedir. Bu nedenle amaç, bu tip bulaşma risklerini "kabul edilebilecek kadar düşük" düzeylere indirgemek olmuştur (1) .Kan ve kan bileşenleri ile birçok enfeksiyon etkeni bulaşabilmektedir. Tarama testlerine rağmen neden enfeksiyon bulaşır sorusuna yanıt şu şekilde verilebilir. Transfüzyonla bulaşan enfeksiyon etkenlerinin dolaşımda uzun süre kalmaları, uzun inkübasyon süreleri, mutant suşların varlığı, asemptomatik klinikle seyretmeleri, kan ve kan bileşenlerinde stabilitelerini korumaları önemli özellikleridir. Enfeksiyon etkenleri arasında virüsler en önemli grubu oluştur-maktadır. En fazla sorun olan virüsler; hepatit B

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Hepatitis B virus DNA–positive, hepatitis B surface antigen–negative blood donations intercepted by anti‐hepatitis B core antigen testing: the Canadian Blood Services experience

Cited by 51 publications

References 22 publications

Residual Risk of Hepatitis-B-Infected Blood Donations: Estimation Methods and Perspectives

Residual Risk of Hepatitis-B-Infected Blood Donations: Estimation Methods and Perspectives

Detección de hepatitis B oculta en donantes de bancos sangre, Colombia 2008-2009

Infectious Agents Transmitted by Blood and Blood Component and Impacts of Nükleik Asit Amplifikasyon Test (NAT)

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