Hepatitis b virus expression and replication in ovum and the influencing factors

Kong, Ying; Ye, Feng; Jin, Yan; Shi, Juanzi; Qiu, Hongtao; Su, Lin

doi:10.4103/1319-3767.182456

Cited by 8 publications

(1 citation statement)

References 18 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…[ 9 , 10 ] The close relationship between HBV covalently closed circular DNA expression in the human ovary, and the high infection rate in infants provides strong evidence for the role of oocytes in intrauterine transmission. [ 11 ] Kong et al [ 12 ] demonstrated that HBV could replicate in oocytes and that transmission to the fetus was associated with serum levels of HBV DNA and the status of hepatitis B envelop antigen (HBeAg). In a previous study, integration of HBV genes was detected in the early stages of hamster embryos; the researchers considered that the gene had been transmitted by sperm from male HBV carriers.…”

Section: Routes Of Vertical Transmissionmentioning

confidence: 99%

Vertical transmission of hepatitis B virus: propositions and future directions

Liu

Chen

Zhao

2021

Chinese Medical Journal

View full text Add to dashboard Cite

Chronic hepatitis B virus (HBV) infection due to vertical transmission remains a critical concern with regards to eliminating HBV infection. Implementation of hepatitis B vaccine, the foundation to prevent perinatal and horizontal transmission, has reduced the prevalence of HBV by >80%. In countries where the hepatitis B immune globulin (HBIG) is available, such as China and the United States, the administration of HBIG and hepatitis B vaccine to the infants of mothers who are positive for hepatitis B surface antigen has become a standard practice and is effective in preventing vertical transmission. Accumulating evidence on the efficacy and safety of antiviral prophylaxis during pregnancy indicates the probability of attaining the goal of the World Health Organization to eliminate hepatitis by 2030. In this review, we discuss the transmission routes, diagnostic criteria, and preventive strategies for vertical transmission. A preventive program that includes screening before pregnancy, antiviral prophylaxis during pregnancy, and postpartum immunoprophylaxis provides “perfect strategies” to eliminate vertical transmission. However, there is still a notable gap between “perfect strategies” and real-world application, including insufficient coverage of timely birth dose vaccine and the efficacy and necessity of HBIG, especially in mothers who are negative for hepatitis B envelope antigen. In particular, there is a clear need for a comprehensive long-term safety profile of antiviral prophylaxis. Therefore, feasible and cost-effective preventive strategies need to be determined across regions. Access also needs to be scaled up to meet the demands for prophylaxis and prevalence targets.

show abstract