Hepatitis B virus genotypes and extrahepatic manifestations

Cacoub, Patrice; Saadoun, David; Bourlière, Marc; Khiri, Hacène; Martineau, Agnès; Benhamou, Yves; Varastet, Marina; Pol, Stanislas; Thibault, Vincent; Rotily, Michel; Halfon, Philippe

doi:10.1016/j.jhep.2005.05.029

Cited by 101 publications

(78 citation statements)

References 24 publications

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“…Moreover, a difference in HBV genotype is not related to the high levels of RF. This result is consistent with the previous report that HBV genotypes are not associated with extrahepatic manifestations 10 .…”

Section: Discussionsupporting

confidence: 94%

“…Furthermore, asymptomatic disorders of immunologic and LPD markers have been observed in patients with CH-B, as well as in patients with CH-C. In one study, 15 of CH-B patients had at least one immunologic abnormality, mainly anti-smooth muscle antibodies and anti-nuclear antibodies 10 . Most of these abnormalities are associated with disorders of B cells.…”

Section: Discussionmentioning

confidence: 99%

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High Level of Rheumatoid Factor is Associated with Hepatitis B Viremia in Patients with Chronic Hepatitis B

Arai

Ito

Miyashita

et al. 2014

Showa Univ J Med Sci

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: Hepatitis viruses are causative agents for chronic hepatitis, liver cirrhosis and hepatocellular carcinoma. However these viruses are also associated with lymphoproliferative disorders LPDs , such as essential mixed cryoglobulinemia and B-cell non-Hodgkin s lymphoma. Indeed, hepatitis C virus infection has been confirmed to be associated with LPDs, but the pathogenic mechanism remains unclear. In this study, we investigated the relationship between hepatitis B virus HBV infection and LPDs in 84 patients with chronic hepatitis B CH-B . LPD markers, such as cryoglobulinemia, high levels of rheumatoid factor RF , hypocomplementemia, and B cell clonality, were measured and analyzed along with viral factors. Results showed that high levels of RF were observed in 39.5 of patients with CH-B. These high RF levels were not associated with abnormal levels of other LPD markers, but only with the presence of HBV DNA in the sera of these patients. Undergoing therapy with nucleotide analogues was also associated with high RF. In two patients with CH-B, decreasing levels of RF were observed during antiviral therapy. In conclusion, high RF levels are associated with HBV viremia in patients with CH-B. HBV infection also plays an important role in the genesis of LPDs in patients with viral hepatitis..

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Section: Discussionsupporting

confidence: 94%

Section: Discussionmentioning

confidence: 99%

High Level of Rheumatoid Factor is Associated with Hepatitis B Viremia in Patients with Chronic Hepatitis B

Arai

Ito

Miyashita

et al. 2014

Showa Univ J Med Sci

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show abstract

“…In India, genotype D was reported to be associated with more severe liver disease than genotype A and that may predict occurrence of HBV HCC in young patients (Kao, 2002). Other European groups (Cacoub et al, 2005) in this area of investigation found similar results to the Portuguese study, and the clinical significance of HBV genotypes remains largely unknown.…”

Section: Discussionmentioning

confidence: 62%

Alcohol consumption among patients with hepatitis B infection in northern Portugal considering gender and hepatitis B virus genotype differences

Mota¹,

Guedes²,

Areias³

et al. 2010

Alcohol

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Alcohol abuse is an important public health problem. In Portugal with a population of 10 millions of inhabitants, there are around 10% of alcoholics or excessive alcohol drinkers and 1% of chronically infected patients with hepatitis B virus (HBV). To examine the characteristics of patients with higher levels of alcohol consumption and to investigate the association between alcohol consumption and liver damage a total of 298 chronically infected individuals, with HBV genotyped and submitted to liver biopsy, were classified with Child's grading and separated by habits of alcohol intake, less and greater than 20 g/day. No significant differences were observed about genotype but genotypes A and D were predominant in both of them. A higher percentage of males (P ! .001) were observed in the group with alcohol intake above 20 g/day, as well a lower proportion of patients with HBeAg negativity (P #.035). In this group, biochemistry parameters, such as alanine aminotransferase (P 5 .006), aspartate aminotransferase (P 5 .001), gamma-glutamyl transferase (P ! .001) were elevated in a significantly higher proportion than in the other group. The analysis of hematological parameters showed significantly lower values of platelets (P 5 .042) and mean corpuscular volume (P ! .001) and significantly higher values of prothrombin time (P ! .001) in the group with higher levels of alcohol consumption. The characteristics of biopsy (P ! .001) and ChildePhug's classification (P 5 .002) revealed more severe results in this group. Logistic regression showed a positive association between liver damage and alcohol intake, increasing with age. In female patients, a strong positive association between alcohol intake and liver damage was also found (odds ratio: 9.379; 95% confidence interval: 0.859e468.422; P 5 .037); however, the most severe cases were only observed in women older than 45 years. In patients with HBV infection, alcohol is associated with a more severe liver disease. No evidence was found concerning association with HBV genotype. Ó

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“…9 For example, in a study of 190 patients with chronic HBV infection, only three had positive cryoglobulins. 10 In another study of 231 patients with MC, the HBsAg was positive in 9% and HBV DNA in 1.8%. 11 In our patient, the pathogenic role of HBV in cryoglobulinemia was confirmed by the positive finding for the HBV DNA in the cryoprecipitate, whereas the HCV RNA was negative.…”

Section: Discussionmentioning

confidence: 95%

Cryoglobulinemic glomerulonephritis in chronic hepatitis B infection

et al. 2010

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Hepatitis B virus (HBV) infection is an uncommon cause of cryoglobulinemia. Renal cryoglobulinemia has been rarely reported in the setting of chronic hepatitis B infection. We describe a case of chronic hepatitis B infection with cryoglobulinemic glomerulonephritis (Gn) and provide information about the treatment and the evolution over a 30-month follow-up. A 41-year-old woman with chronic hepatitis B infection developed nephrotic syndrome and acute renal failure; other investigations revealed type 2 cryoglobulinemia; HBV DNA was detected in the cryoprecipitate. Renal biopsy showed findings of cryoglobulinemic Gn. She was given lamivudine, corticosteroids, plasma exchange, and mycophenolate mofetil. The renal function improved, nephrotic syndrome remitted, and HBV DNA became undetectable; there was no compromise of the liver function.

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Hepatitis B virus genotypes and extrahepatic manifestations

Cited by 101 publications

References 24 publications

High Level of Rheumatoid Factor is Associated with Hepatitis B Viremia in Patients with Chronic Hepatitis B

High Level of Rheumatoid Factor is Associated with Hepatitis B Viremia in Patients with Chronic Hepatitis B

Alcohol consumption among patients with hepatitis B infection in northern Portugal considering gender and hepatitis B virus genotype differences

Cryoglobulinemic glomerulonephritis in chronic hepatitis B infection

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