Hepatitis B virus genotypes in chronic liver disease patients from New Delhi, India

Chattopadhyay, Saket; Das, Bhudev C.; Kar, Premashis

doi:10.3748/wjg.v12.i41.6702

Cited by 50 publications

(40 citation statements)

References 16 publications

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“…But, we did not observe genotype E in our population as the study of Singh et al, 23 in accordance with the study of Kar et al 24 Chattopadhyay et al 25 reported predominance of genotype D followed by genotype A among patients with chronic liver disease from New Delhi.…”

Section: Conflicts Of Interestsupporting

confidence: 86%

Prevalence of Genotype D and Precore/Core Promoter Mutations in Hepatitis B Virus-infected Population of North India

Kumar¹,

Pahal²,

Singh³

2011

Journal of Clinical and Experimental Hepatology

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Hepatitis B virus (HBV) isolates (21) from Punjab (North India) were studied for genotype distribution and precore/core promoter mutations. Assays of alanine aminotransaminase (ALT) and HBeAg were performed in all isolates. Genotypes were determined in all the samples by restriction fragment length polymorphism and the precore/core promoter mutations were studied by amplification and by direct sequencing of precore/core promoter region. Sixty-two percent of the isolates had higher ALT levels and 57% of the isolates were HBeAg negative. It was observed that 90% of the isolates were HBV D genotype (subgenotype D1 and D2) and 10% of the isolates were HBV A genotype (subgenotype A1). Amplification and sequencing of the precore/core promoter region showed

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Section: Conflicts Of Interestsupporting

confidence: 86%

Prevalence of Genotype D and Precore/Core Promoter Mutations in Hepatitis B Virus-infected Population of North India

Kumar¹,

Pahal²,

Singh³

2011

Journal of Clinical and Experimental Hepatology

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“…We and others from India have reported the presence of mixed genotype A and D [9][10][11][12] . However, despite the presence of mixed genotypes, there are no reports from India about the presence of recombination, especially using the full-length HBV genome sequencing approach.…”

Section: H E P a T I T I S B V I R U S ( H Bmentioning

confidence: 56%

Identification and characterization of genotype A and D recombinant hepatitis B virus from Indian chronic HBV isolates

Chauhan

Kazim²,

Kumar³

et al. 2008

WJG

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AIM:To confirm the presence of recombination, fulllength hepatitis B virus (HBV) from chronic patients was sequenced and analyzed. METHODS: Full-length HBV genomes from 12 patients were amplified and sequenced in an automated sequencer. Phylogenetic analysis was carried out on full-length, Core and preS2/Surface regions using MEGA software. SimPlot Boot Scanning and amino acid sequence analysis were performed for confirmation of recombination. RESULTS: Eight patients were infected with genotype D strain; one patient with genotype A and three patients had genotype A and D recombination; two of them had cirrhosis and one had hepatocellular carcinoma. Phylogenetic analysis of core and preS2/surface regions separately showed evidence of genotype A and D recombination. The breakpoints of recombination were found to be at the start of preS2 and at the end

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“…10 But the traditional restriction fragment length polymorphism (RFLP) methods can identify only genotypes A-F. Zeng et al 11 carried out an RFLP using digestion of enzymes BsrI, StyI, DpnI, HpaII, and EaeI, in 240 HBV S gene isolates (obtained from GeneBank) and demonstrated all eight genotypes. Chattopadhyay et al 12 demonstrated the RFLP and PCR using type-specific primers for genotyping agreed well with sequencing among 100 HBV-DNApositive North Indian patients.…”

Section: Restriction Fragment Length Polymorphismmentioning

confidence: 85%

Hepatitis B Virus Genotyping: Is the Time Ripe for Routine Clinical Use?

Madan¹,

Tyagi²

2012

Journal of Clinical and Experimental Hepatology

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Hepatitis B virus genotypes in chronic liver disease patients from New Delhi, India

Cited by 50 publications

References 16 publications

Prevalence of Genotype D and Precore/Core Promoter Mutations in Hepatitis B Virus-infected Population of North India

Prevalence of Genotype D and Precore/Core Promoter Mutations in Hepatitis B Virus-infected Population of North India

Identification and characterization of genotype A and D recombinant hepatitis B virus from Indian chronic HBV isolates

Hepatitis B Virus Genotyping: Is the Time Ripe for Routine Clinical Use?

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